Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
DiMauro, E.F., Newcomb, J., Nunes, J.J., Bemis, J.E., Boucher, C., Chai, L., Chaffee, S.C., Deak, H.L., Epstein, L.F., Faust, T., Gallant, P., Gore, A., Gu, Y., Henkle, B., Hsieh, F., Huang, X., Kim, J.L., Lee, J.H., Martin, M.W., McGowan, D.C., Metz, D., Mohn, D., Morgenstern, K.A., Oliveira-dos-Santos, A., Patel, V.F., Powers, D., Rose, P.E., Schneider, S., Tomlinson, S.A., Tudor, Y.Y., Turci, S.M., Welcher, A.A., Zhao, H., Zhu, L., Zhu, X.
J.Med.Chem.