PDB 2fak

PDB Links
Overview

PDB Information

PDB	2FAK
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding. Groll, M., Huber, R., Potts, B.C. J.Am.Chem.Soc.
Header	Hydrolase
Released	2005-12-07
Resolution	2.800
CATH Insert Date	14 Jul, 2006

PDB Images (57)

2fak

PDB 2fak

2fak1

PDB Chain 2fak1

2fak2

PDB Chain 2fak2

2fakA

PDB Chain 2fakA

2fakB

PDB Chain 2fakB

2fakC

PDB Chain 2fakC

2fakD

PDB Chain 2fakD

2fakE

PDB Chain 2fakE

2fakF

PDB Chain 2fakF

2fakG

PDB Chain 2fakG

2fakH

PDB Chain 2fakH

2fakI

PDB Chain 2fakI

2fakJ

PDB Chain 2fakJ

2fakK

PDB Chain 2fakK

2fakL

PDB Chain 2fakL

2fakM

PDB Chain 2fakM

2fakN

PDB Chain 2fakN

2fakO

PDB Chain 2fakO

2fakP

PDB Chain 2fakP

2fakQ

PDB Chain 2fakQ

2fakR

PDB Chain 2fakR

2fakS

PDB Chain 2fakS

2fakT

PDB Chain 2fakT

2fakU

PDB Chain 2fakU

2fakV

PDB Chain 2fakV

2fakW

PDB Chain 2fakW

2fakX

PDB Chain 2fakX

2fakY

PDB Chain 2fakY

2fakZ

PDB Chain 2fakZ

2fak100

CATH Domain 2fak100

2fak200

CATH Domain 2fak200

2fakA00

CATH Domain 2fakA00

2fakB00

CATH Domain 2fakB00

2fakC00

CATH Domain 2fakC00

2fakD00

CATH Domain 2fakD00

2fakE00

CATH Domain 2fakE00

2fakF00

CATH Domain 2fakF00

2fakG00

CATH Domain 2fakG00

2fakH00

CATH Domain 2fakH00

2fakI00

CATH Domain 2fakI00

2fakJ00

CATH Domain 2fakJ00

2fakK00

CATH Domain 2fakK00

2fakL00

CATH Domain 2fakL00

2fakM00

CATH Domain 2fakM00

2fakN00

CATH Domain 2fakN00

2fakO00

CATH Domain 2fakO00

2fakP00

CATH Domain 2fakP00

2fakQ00

CATH Domain 2fakQ00

2fakR00

CATH Domain 2fakR00

2fakS00

CATH Domain 2fakS00

2fakT00

CATH Domain 2fakT00

2fakU00

CATH Domain 2fakU00

2fakV00

CATH Domain 2fakV00

2fakW00

CATH Domain 2fakW00

2fakX00

CATH Domain 2fakX00

2fakY00

CATH Domain 2fakY00

2fakZ00

CATH Domain 2fakZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
1	14 Jul, 2006	Chopped
2	14 Jul, 2006	Chopped
A	14 Jul, 2006	Chopped
B	14 Jul, 2006	Chopped
C	14 Jul, 2006	Chopped
D	14 Jul, 2006	Chopped
E	14 Jul, 2006	Chopped
F	14 Jul, 2006	Chopped
G	14 Jul, 2006	Chopped
H	14 Jul, 2006	Chopped
I	14 Jul, 2006	Chopped
J	14 Jul, 2006	Chopped
K	14 Jul, 2006	Chopped
L	14 Jul, 2006	Chopped
M	14 Jul, 2006	Chopped
N	14 Jul, 2006	Chopped
O	14 Jul, 2006	Chopped
P	14 Jul, 2006	Chopped
Q	14 Jul, 2006	Chopped
R	14 Jul, 2006	Chopped
S	14 Jul, 2006	Chopped
T	14 Jul, 2006	Chopped
U	14 Jul, 2006	Chopped
V	14 Jul, 2006	Chopped
W	14 Jul, 2006	Chopped
X	14 Jul, 2006	Chopped
Y	14 Jul, 2006	Chopped
Z	14 Jul, 2006	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
2fak100	16 Oct, 2006	3.60.20.10	Assigned
2fak200	16 Oct, 2006	3.60.20.10	Assigned
2fakA00	16 Oct, 2006	3.60.20.10	Assigned
2fakB00	16 Oct, 2006	3.60.20.10	Assigned
2fakC00	16 Oct, 2006	3.60.20.10	Assigned
2fakD00	16 Oct, 2006	3.60.20.10	Assigned
2fakE00	16 Oct, 2006	3.60.20.10	Assigned
2fakF00	16 Oct, 2006	3.60.20.10	Assigned
2fakG00	16 Oct, 2006	3.60.20.10	Assigned
2fakH00	16 Oct, 2006	3.60.20.10	Assigned
2fakI00	16 Oct, 2006	3.60.20.10	Assigned
2fakJ00	16 Oct, 2006	3.60.20.10	Assigned
2fakK00	16 Oct, 2006	3.60.20.10	Assigned
2fakL00	16 Oct, 2006	3.60.20.10	Assigned
2fakM00	16 Oct, 2006	3.60.20.10	Assigned
2fakN00	16 Oct, 2006	3.60.20.10	Assigned
2fakO00	16 Oct, 2006	3.60.20.10	Assigned
2fakP00	16 Oct, 2006	3.60.20.10	Assigned
2fakQ00	16 Oct, 2006	3.60.20.10	Assigned
2fakR00	16 Oct, 2006	3.60.20.10	Assigned
2fakS00	16 Oct, 2006	3.60.20.10	Assigned
2fakT00	16 Oct, 2006	3.60.20.10	Assigned
2fakU00	16 Oct, 2006	3.60.20.10	Assigned
2fakV00	16 Oct, 2006	3.60.20.10	Assigned
2fakW00	16 Oct, 2006	3.60.20.10	Assigned
2fakX00	16 Oct, 2006	3.60.20.10	Assigned
2fakY00	16 Oct, 2006	3.60.20.10	Assigned
2fakZ00	16 Oct, 2006	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1