Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
Bernstein, P.R., Andisik, D., Bradley, P.K., Bryant, C.B., Ceccarelli, C., Damewood Jr., J.R., Earley, R., Edwards, P.D., Feeney, S., Gomes, B.C., Kosmider, B.J., Steelman, G.B., Thomas, R.M., Vacek, E.P., Veale, C.A., Williams, J.C., Wolanin, D.J., Woolson, J.A.
J.Med.Chem.