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CATH Superfamily 3.40.50.11580

nsp15 middle domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: nsp15 middle domain

The unique coronavirus transcription/replication machinery comprised of multiple virus-encoded nonstructural proteins (nsp) plays a vital role during initial and intermediate phases of the viral life cycle.

nsp15 forms a hexamer which is suggested to be a functional unit. It also has endoribonuclease activity. The nsp15 monomer consists of three domains. This entry represents the middle domain which is made up of a major mixed beta-sheet, three small ones and two short alpha-helices PMID:16873248.

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
5 Unique EC terms

Species Diversity

Unique species annotations
154 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 27
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 8
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Function
Unique EC: 5
Unique GO: 3
Taxonomy
Unique Species: 154