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CATH Superfamily 3.40.50.10900

PAC-like subunit

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PAC-like subunit
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: PAC-like subunit

This superfamily represents the PAC (proteasome-assembly chaperone) subunit. Its C-terminal segment containing the potential proteasome-activating HbYX motif.

This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.

PFAM:PF09754,DOI:10.1016/j.bbrc.2014.09.114

GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
3716 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 26
Domain clusters (>95% seq id): 9
Domain clusters (>35% seq id): 7
Unique PDBs: 9
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 33
Function
Unique EC:
Unique GO: 10
Taxonomy
Unique Species: 3716