The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
RepB DNA-primase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: RepB DNA-primase, N-terminal domain

This superfamily entry represents the N-terminal domain of RepB DNA-primase produced by P4-like phages. It is a zinc-independent primase unlike Pri-type primases.

Primases are necessary for phage replication. RepBprime primases such as in this family recognise both ssiA and ssiB, ie only 1 single-stranded primase initiation site on each strand, independently of each other and then synthesise primers that are elongated by DNA polymerase III. The phage is thus replicated exclusively in leading strand mode PFAM:PF16793.

RepB has a dumbbell shaped and comprises two domains: an N-terminal catalytic domain (composed of 2 antiparallel beta-sheets flanked by 6 alpha-helices) separated by a long alpha-helix plus tether and a C-terminal helical-bundle domain (made up of 5 helices) DOI:10.1073/pnas.0902910106.

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
48 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 1
Unique GO:
Taxonomy
Unique Species: 48
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