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CATH Superfamily 3.30.110.110

Mre11, capping domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Mre11, capping domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Mre11, capping domain

The Mre11-Rad50-Nbs1 (MRN) complex tethers, processes and signals DNA double strand breaks, promoting genomic stability. Mre11 dimerizes via phosphodiesterase domains flanked by a alpha/beta capping domain, process which creates a U-shaped particle with a broad DNA/Rad50 binding cleft. Structural domains comprising this superfamily share the structure of Mre11's capping domain )PMID:22705791.

GO Diversity

Unique GO annotations
88 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1416 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 14
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 18
Function
Unique EC:
Unique GO: 88
Taxonomy
Unique Species: 1416