View in Gene3D

CATH Superfamily 2.60.40.2030

CalX-beta domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: CalX-beta domain

The calx-beta motif is present as a tandem repeat in the cytoplasmic domains of Calx Na-Ca exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-beta motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in some cyanobacterial proteins. This motif contains a series of beta-strands and turns that form a self-contained beta-sheet PMID:9294196,PMID:10390612 (INTERPRO:IPR038081).

GO Diversity

Unique GO annotations
198 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
3479 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 39
Domain clusters (>95% seq id): 8
Domain clusters (>35% seq id): 5
Unique PDBs: 18
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 61
Function
Unique EC:
Unique GO: 198
Taxonomy
Unique Species: 3479