View in Gene3D

CATH Superfamily 2.60.40.1840

Aminopeptidase N, middle-beta domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Aminopeptidase N, middle-beta domain

Aminopeptidase N is a well conserved enzyme in a variety of species such as mammals, insects, plants, and bacteria. Together with certain endopeptidases, aminopeptidase N plays a major role in peptide degradation, which enables the utilization of amino acids as nutrients. The enzyme is composed of four domains: an N-terminal beta-domain, a catalytic domain, a middle beta-domain, and a C-terminal alpha-domain PMID:16885166. This entry represents the middle-beta domain which exhibits an Ig-like fold. Its function remains unclear.

GO Diversity

Unique GO annotations
18 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
3699 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 105
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 3
Unique PDBs: 102
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 6
Function
Unique EC: 2
Unique GO: 18
Taxonomy
Unique Species: 3699