View in Gene3D

CATH Superfamily 2.30.29.210

FACT complex subunit Spt16p/Cdc68p

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FACT complex subunit Spt16p/Cdc68p
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: FACT complex subunit Spt16p/Cdc68p

Facilitates chromatin transcription (FACT) is a conserved histone chaperone that reorganizes nucleosomes and ensures chromatin integrity during DNA transcription, replication and repair. To carry out its broad functions FACT needs to be able to recognise histones H2A-H2B. Structural domains comprising this superfamily share the structure of subunit Spt16M of the FACT complex. Spt16M makes several interactions with histones, gradually blocking the strongest interaction of H2B with DNA. This process is often referred to as 'nucleosome breathing' based on the re-organization of the first 30 base pairs of nucleosomal histone-DNA contacts PMID:23698368.

GO Diversity

Unique GO annotations
36 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1421 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 6
Function
Unique EC:
Unique GO: 36
Taxonomy
Unique Species: 1421