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CATH Superfamily 2.30.29.160

Zinc finger FYVE domain-containing protein 21, C-terminal

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zinc finger FYVE domain-containing protein 21, C-terminal
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Zinc finger FYVE domain-containing protein 21, C-terminal

According to available literature members of this superfamily share the structure of the C-terminal domain of Zinc finger FYVE domain-containing protein 21 (ZF21), involved in beta-tubulin binding. ZF21 regulates focal adhesions and cell migration binds by binding multiple factors that promote disassembly of FAs such as FAK, beta-tubulin, m-calpain, and SHP-2. This C-terminal domain of ZF21 is therefore key in FA disassembly and cell migration PMID:21768110. This domain is annotated in InterPro to have a PH-like fold (INTERPRO:IPR032031).

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
195 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 195