Structural domains comprising this superfamily share the structure of members of the peptidase M41 family, which belongs to a larger family of zinc metalloproteases. Members of this superfamily include the cell division protein FtsH and the yeast mitochondrial respiratory chain complexes assembly protein, a putative ATP-dependent protease required for assembly of the mitochondrial respiratory chain and ATPase complexes. FtsH is an integral membrane protein and seems to behave as an ATP-dependent zinc metallopeptidase that binds one zinc ion.