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CATH Superfamily 1.20.120.770

Amyloid precursor protein, E2 domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Amyloid precursor protein, E2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Amyloid precursor protein, E2 domain

The E2 domain is the largest of the conserved domains of the amyloid precursor protein (APP) associated with Alzheimer's Disease (AD). The structure of E2 consists of two coiled-coil sub-structures connected through a continuous helix.

GO Diversity

Unique GO annotations
182 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
383 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 24
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 2
Unique PDBs: 17
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 5
Function
Unique EC:
Unique GO: 182
Taxonomy
Unique Species: 383