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CATH Superfamily 1.10.287.130

Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain

Two-component signal transduction systems (TCSs) are promising targets for new antimicrobial research because they help bacteria and fungi adapt and survive. One of the main components of TCSs is a sensor histidine kinase (SK), which relays extracellular signals to intracellular pathways. Sensor histidine kinases are composed of HAMP, PAS, DHp, catalytic and ATP binding domains in addition to a short transmembrane domain PMID:23468592. This entry represents the dimerisation and phosphotransfer domain (DHp). The dimer forms a closed, four-helical bundle with a left-handed twist, consisting of the two identical alpha-hairpin subunits (INTERPRO:IPR003661) .

PMID:23468592 (INTERPRO:IPR003661)

GO Diversity

Unique GO annotations
237 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
21662 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 108
Domain clusters (>95% seq id): 31
Domain clusters (>35% seq id): 19
Unique PDBs: 53
Alignments
Structural Clusters (5A): 5
Structural Clusters (9A): 4
FunFam Clusters: 273
Function
Unique EC: 3
Unique GO: 237
Taxonomy
Unique Species: 21662