CATH Documentation
CATH Release Notes
The CATH database is constantly being updated through automated algorithms and manual curation.
The most up-to-date annotations can be found in the CATH daily snapshots where we provide a limited amount of information (domain boundaries and superfamily assignments) for the very latest snapshot of the current database.
We also provide major releases (CATH-Plus) where we take a branch of the database through the full release process: adding internal checks, associating functional and sequence annotations, creating datasets, and so on.
Information from all releases can be downloaded from the Download page, general stats on each CATH-Plus release is provided below.
CATH-Plus Version 4.3
Based on PDB release: July 01, 2019
Changes since v4.2:
- 65,381 newly classified domains
- 25,311 newly processed PDBs
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
Class 1 | 5 | 404 | 2033 | 7817 | 10238 | 13421 | 26121 | 103788 |
Class 2 | 21 | 244 | 1290 | 6998 | 9877 | 16235 | 29211 | 124032 |
Class 3 | 14 | 634 | 2337 | 16373 | 24356 | 31614 | 64907 | 262275 |
Class 4 | 1 | 108 | 181 | 386 | 497 | 676 | 1112 | 5716 |
Class 6 | 2 | 82 | 790 | 814 | 867 | 969 | 1376 | 4427 |
TOTAL | 41 | 1390 | 6631 | 32388 | 45835 | 62915 | 122727 | 500238 |
CATH-Plus Version 4.2
Based on PDB release: July 01, 2017
Changes since v4.1:
- 125,858 newly classified domains
- 24,765 newly processed PDBs
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
Class 1 | 5 | 405 | 2174 | 7771 | 9948 | 12797 | 24176 | 90302 |
Class 2 | 21 | 244 | 1395 | 7011 | 9627 | 15169 | 26904 | 110260 |
Class 3 | 14 | 634 | 2428 | 16196 | 23313 | 29670 | 60020 | 229776 |
Class 4 | 1 | 108 | 122 | 311 | 399 | 542 | 876 | 4519 |
TOTAL | 41 | 1391 | 6119 | 31289 | 43287 | 58178 | 111976 | 434857 |
CATH-Plus Version 4.1
Based on PDB release: Jan 01, 2015
Changes since v4.0:
- 73,141 newly classified domains
- 17,444 newly processed PDBs
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
Class 1 | 5 | 396 | 908 | 4645 | 6190 | 8174 | 16299 | 61579 |
Class 2 | 20 | 241 | 547 | 4641 | 6639 | 10687 | 18460 | 78049 |
Class 3 | 14 | 628 | 1160 | 11617 | 17134 | 21834 | 44966 | 165745 |
Class 4 | 1 | 108 | 122 | 252 | 322 | 442 | 697 | 3626 |
TOTAL | 40 | 1373 | 2737 | 21155 | 30285 | 41137 | 80422 | 308999 |
CATH-Plus Version 4.0
Based on PDB release: March 26, 2013
Changes since v3.5:
- 62,322 newly assigned domains
- 112 new homologous superfamilies
- 62 new folds (topologies)
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
Class 1 | 5 | 397 | 907 | 3879 | 5118 | 6737 | 13368 | 48121 |
Class 2 | 20 | 241 | 547 | 3650 | 5221 | 8373 | 14526 | 58944 |
Class 3 | 14 | 626 | 1158 | 9171 | 13415 | 17047 | 35313 | 125772 |
Class 4 | 1 | 111 | 126 | 233 | 293 | 410 | 651 | 3021 |
TOTAL | 40 | 1375 | 2738 | 16933 | 24047 | 32567 | 63858 | 235858 |
CATH-Plus Version 3.5
Based on PDB release: Sept 20, 2011
Changes since v3.4:
- 20,616 newly assigned domains
- 77 new homologous superfamilies
- 31 new folds (topologies)
The table below summarises the number of clusters within each of the four classes in CATH.
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
1 | 5 | 386 | 875 | 2917 | 3843 | 5069 | 10098 | 37038 |
2 | 20 | 229 | 520 | 2618 | 3796 | 6147 | 10744 | 43881 |
3 | 14 | 594 | 1113 | 6183 | 9107 | 11668 | 24452 | 90029 |
4 | 1 | 104 | 118 | 208 | 259 | 359 | 574 | 2588 |
Total | 40 | 1313 | 2626 | 11926 | 17005 | 23243 | 45868 | 173536 |
CATH-Plus Version 3.4
Based on PDB release: Nov 13, 2010
Changes since v3.3:
- 24,232 newly assigned domains
- 163 new homologous superfamilies
- 49 new folds (topologies)
The table below summarises the number of clusters within each of the four classes in CATH.
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
1 | 5 | 376 | 839 | 2763 | 3571 | 4679 | 9217 | 32396 |
2 | 20 | 228 | 514 | 2514 | 3573 | 5668 | 9824 | 39140 |
3 | 14 | 577 | 1082 | 5849 | 8381 | 10626 | 21900 | 79038 |
4 | 1 | 101 | 114 | 204 | 253 | 352 | 547 | 2346 |
Total | 40 | 1282 | 2549 | 11330 | 15778 | 21325 | 41488 | 152920 |
CATH-Plus Version 3.3
Based on PDB release: July 7, 2009
Changes since v3.2:
- 14,473 newly assigned domains
- 199 new homologous superfamilies
- 123 new folds (topologies)
The table below summarises the number of clusters within each of the four classes in CATH.
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
1 | 5 | 360 | 773 | 2400 | 3092 | 4040 | 7838 | 26880 |
2 | 14 | 558 | 1031 | 5151 | 7294 | 9192 | 18679 | 66456 |
3 | 20 | 217 | 473 | 2283 | 3225 | 5002 | 8589 | 33469 |
4 | 1 | 98 | 109 | 185 | 233 | 323 | 477 | 1883 |
Total | 40 | 1233 | 2386 | 10019 | 13844 | 18557 | 35583 | 128688 |
CATH-Plus Version 3.2
Based on PDB release: July 14, 2008
The v3.2.0 release of CATH has a number of improvements in the backend data and the frontend web pages.
Changes since v3.1:
- 20,330 newly assigned domains
- 87 new homologous superfamilies
- 26 new folds (topologies)
The table below summarises the number of clusters within each of the four classes in CATH.
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
1 | 5 | 310 | 682 | 2078 | 2689 | 3540 | 6685 | 23491 |
2 | 20 | 196 | 438 | 2062 | 2902 | 4468 | 7656 | 29992 |
3 | 14 | 512 | 956 | 4558 | 6473 | 8135 | 16346 | 58967 |
4 | 1 | 92 | 102 | 173 | 217 | 301 | 445 | 1765 |
Total | 40 | 1110 | 2178 | 8871 | 12281 | 16444 | 31132 | 114215 |
CATH-Plus Version 3.1
Based on PDB release: 14 Jan, 2007
We spent a great deal of effort identifying and correcting errors such as incorrectly chopped chains and misassigned domains. This meant that a number of homologous superfamilies (and folds) were merged with other nodes or removed as CATH domains were rechopped or reassigned.
Changes since v3.0:
- 7,734 newly assigned domains
- 47 homologous superfamilies were merged or removed
- 26 folds (topologies) were merged or removed
The table below summarises the number of clusters within each of the four classes in CATH.
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
1 | 5 | 305 | 652 | 1850 | 2329 | 3001 | 5587 | 19729 |
2 | 20 | 191 | 415 | 1860 | 2531 | 3846 | 6503 | 25537 |
3 | 14 | 496 | 922 | 3922 | 5303 | 6659 | 12998 | 47193 |
4 | 1 | 92 | 102 | 162 | 200 | 275 | 403 | 1426 |
Total | 40 | 1084 | 2091 | 7794 | 10363 | 13781 | 25491 | 93885 |
CATH-Plus Version 3.0
Based on PDB release: 5 May, 2006
Class | Architecture | Topology | Homologous Superfamily | S35 Family | S60 Family | S95 Family | S100 Family | Domains |
---|---|---|---|---|---|---|---|---|
1 | 5 | 316 | 674 | 1877 | 2280 | 2862 | 5207 | 18271 |
2 | 20 | 195 | 428 | 1843 | 2436 | 3653 | 6152 | 23482 |
3 | 14 | 506 | 941 | 3956 | 5103 | 6239 | 12184 | 43025 |
4 | 1 | 93 | 104 | 165 | 197 | 267 | 387 | 1373 |
Total | 40 | 1110 | 2147 | 7841 | 10016 | 13021 | 23930 | 86151 |