The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
signal transducer and activator of transcription 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Signal transducer and activator of transcription

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 48 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(12 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 B0JYL6 (/IPI) B0JYL6 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42225 (/IPI)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P42224 (/ISA) P42224 (/ISA) P42224 (/ISA) P42224 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P42224 (/ISM) P42224 (/ISM) P42224 (/ISM) P42224 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P42224 (/NAS) P42224 (/NAS) P42224 (/NAS) P42224 (/NAS)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
4 P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
4 P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
4 P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
4 P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
4 P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Ubiquitin-like protein ligase binding GO:0044389
Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.
4 P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
4 P42224 (/HDA) P42224 (/HDA) P42224 (/HDA) P42224 (/HDA)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
4 P42224 (/IPI) P42224 (/IPI) P42224 (/IPI) P42224 (/IPI)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 A0A0G2JX93 (/TAS) F1M9D6 (/TAS) Q9QXK0 (/TAS)
CCR5 chemokine receptor binding GO:0031730
Interacting selectively and non-covalently with a CCR5 chemokine receptor.
3 A0A0G2JX93 (/IPI) F1M9D6 (/IPI) Q9QXK0 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
3 A0A0G2JX93 (/IPI) F1M9D6 (/IPI) Q9QXK0 (/IPI)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
2 P42225 (/ISS) Q764M5 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P42225 (/ISS) Q764M5 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P42225 (/ISO)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
1 P42225 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P42225 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P42225 (/ISO)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P42225 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P42225 (/IMP)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P42225 (/ISO)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
1 P42225 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P42225 (/ISO)
CCR5 chemokine receptor binding GO:0031730
Interacting selectively and non-covalently with a CCR5 chemokine receptor.
1 P42225 (/ISO)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
1 P42225 (/ISO)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
1 P42225 (/ISO)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
1 P42225 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P42225 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P42225 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P42225 (/ISO)
Ubiquitin-like protein ligase binding GO:0044389
Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.
1 P42225 (/ISO)
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
1 P42225 (/ISO)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
1 P42225 (/ISO)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
1 P42225 (/ISO)

There are 129 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136
The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Metanephric mesenchymal cell differentiation GO:0072162
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0072308
Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.
26 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(16 more)
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
22 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(12 more)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
22 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(12 more)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
22 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(12 more)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(12 more)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
22 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(12 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
22 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(12 more)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
21 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(11 more)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
21 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(11 more)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
21 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(11 more)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
21 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(11 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42225 (/ISS)
Positive regulation of mesenchymal cell proliferation GO:0002053
The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
5 P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42225 (/ISS)
Negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340
Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
5 P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42225 (/ISS)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
5 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42225 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
5 P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) Q764M5 (/ISS)
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
4 P42224 (/IGI) P42224 (/IGI) P42224 (/IGI) P42224 (/IGI)
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Positive regulation of transcription of Notch receptor target GO:0007221
The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Macrophage derived foam cell differentiation GO:0010742
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Response to interferon-beta GO:0035456
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Cellular response to interferon-beta GO:0035458
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Interleukin-9-mediated signaling pathway GO:0038113
A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Interleukin-21-mediated signaling pathway GO:0038114
A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P42224 (/IGI) P42224 (/IGI) P42224 (/IGI) P42224 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Negative regulation by virus of viral protein levels in host cell GO:0046725
Any process where the infecting virus reduces the levels of viral proteins in a cell.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Regulation of interferon-gamma-mediated signaling pathway GO:0060334
Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Renal tubule development GO:0061326
The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
4 P42224 (/IMP) P42224 (/IMP) P42224 (/IMP) P42224 (/IMP)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Interleukin-27-mediated signaling pathway GO:0070106
A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Interleukin-35-mediated signaling pathway GO:0070757
A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
3 A0A0G2JX93 (/IMP) F1M9D6 (/IMP) Q9QXK0 (/IMP)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
3 A0A0G2JX93 (/TAS) F1M9D6 (/TAS) Q9QXK0 (/TAS)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
3 A0A0G2JX93 (/IMP) F1M9D6 (/IMP) Q9QXK0 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
3 A0A0G2JX93 (/IEP) F1M9D6 (/IEP) Q9QXK0 (/IEP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
3 A0A0G2JX93 (/IEP) F1M9D6 (/IEP) Q9QXK0 (/IEP)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
3 A0A0G2JX93 (/IMP) F1M9D6 (/IMP) Q9QXK0 (/IMP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
3 A0A0G2JX93 (/IMP) F1M9D6 (/IMP) Q9QXK0 (/IMP)
Macrophage derived foam cell differentiation GO:0010742
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
2 P42225 (/ISS) Q764M5 (/ISS)
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
2 P42225 (/ISS) Q764M5 (/ISS)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
2 P42225 (/ISS) Q764M5 (/ISS)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 P42225 (/ISS) Q764M5 (/ISS)
Renal tubule development GO:0061326
The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
2 P42225 (/ISS) Q9QXK0 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9QXK0 (/IMP)
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
1 P42225 (/ISO)
Positive regulation of mesenchymal cell proliferation GO:0002053
The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
1 Q9QXK0 (/IMP)
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
1 P42225 (/ISO)
Negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340
Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
1 Q9QXK0 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P42225 (/IMP)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 P42225 (/IMP)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
1 P42225 (/ISO)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 P42225 (/ISO)
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
1 P42225 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P42225 (/ISO)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P42225 (/ISO)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 P42225 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9QXK0 (/IMP)
Macrophage derived foam cell differentiation GO:0010742
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
1 P42225 (/ISO)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 P42225 (/ISO)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P42225 (/IDA)
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
1 P42225 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P42225 (/IDA)
Positive regulation of interferon-alpha production GO:0032727
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
1 P42225 (/ISO)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P42225 (/ISO)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P42225 (/ISO)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P42225 (/ISO)
Negative regulation of macrophage fusion GO:0034240
Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion.
1 P42225 (/IMP)
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P42225 (/IDA)
Response to interferon-beta GO:0035456
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
1 P42225 (/ISO)
Cellular response to interferon-beta GO:0035458
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
1 P42225 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P42225 (/ISO)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 P42225 (/ISO)
Response to exogenous dsRNA GO:0043330
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
1 P42225 (/IDA)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P42225 (/ISO)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
1 P42225 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P42225 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P42225 (/ISO)
Negative regulation by virus of viral protein levels in host cell GO:0046725
Any process where the infecting virus reduces the levels of viral proteins in a cell.
1 P42225 (/ISO)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 P42225 (/ISO)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 P42225 (/ISO)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 P42225 (/ISO)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
1 P42225 (/ISO)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 P42225 (/ISO)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P42225 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P42225 (/ISO)
Renal tubule development GO:0061326
The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
1 P42225 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P42225 (/IMP)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 A0A0G2JX93 (/IDA)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P42225 (/ISO)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
1 P42225 (/ISO)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 A0A0G2JX93 (/IDA)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P42225 (/ISO)
Metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136
The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population.
1 Q9QXK0 (/IMP)
Metanephric mesenchymal cell differentiation GO:0072162
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state.
1 Q9QXK0 (/IMP)
Negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0072308
Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.
1 Q9QXK0 (/IMP)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
22 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(12 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
21 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(11 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
21 B0JYL6 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(11 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
16 A0A0D9RIE1 (/IDA) A0A0D9RIE1 (/IDA) A0A0D9RIE1 (/IDA) A0A0D9RIE1 (/IDA) A0A0D9RIE1 (/IDA) A0A0D9RIE1 (/IDA) A0A0D9RIE1 (/IDA) A0A0D9RIE1 (/IDA) A0A0G2JX93 (/IDA) F1M9D6 (/IDA)
(6 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 A0A0G2JX93 (/IDA) B0JYL6 (/IDA) B0JYL6 (/IDA) F1M9D6 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42225 (/IDA) Q9QXK0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42225 (/TAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
5 P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42225 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
5 P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42224 (/ISS) P42225 (/ISS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P42224 (/TAS) P42224 (/TAS) P42224 (/TAS) P42224 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P42224 (/IDA) P42224 (/IDA) P42224 (/IDA) P42224 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
3 A0A0G2JX93 (/IDA) F1M9D6 (/IDA) Q9QXK0 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P42225 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P42225 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P42225 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P42225 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P42225 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P42225 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P42225 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P42225 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P42225 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P42225 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...