CATH Superfamily 4.10.80.340
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1: Protein V
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P11207 (/IPI) P11207 (/IPI) P30927 (/IPI) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Suppression by virus of host MDA-5 activity GO:0039554
Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
|
4 | F8V2V1 (/IDA) F8V2V1 (/IDA) P11207 (/IDA) P11207 (/IDA) |
|
Suppression by virus of host type I interferon production GO:0039501
Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
2 | Q997F2 (/IDA) Q997F2 (/IDA) |
|
Suppression by virus of host apoptotic process GO:0019050
Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication.
|
1 | P0C765 (/IDA) |
|
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | I7BT83 (/IMP) |
|
Suppression by virus of host innate immune response GO:0039503
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense.
|
1 | P69282 (/IMP) |
|
Suppression by virus of host IRF3 activity GO:0039548
Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.
|
1 | P69282 (/IDA) |
|
Suppression by virus of host STAT1 activity GO:0039563
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
|
1 | P0C765 (/IDA) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Host cell cytoplasm GO:0030430
The cytoplasm of a host cell.
|
3 | P0C765 (/IDA) Q997F2 (/IDA) Q997F2 (/IDA) |
|
Host cell nucleus GO:0042025
A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P0C765 (/IDA) |
|
Host cell cytosol GO:0044164
The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P69282 (/IDA) |
