The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 18: Aryl hydrocarbon receptor nuclear translocator-lik...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 38 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
19 |
A0A0R4IH97 (/IPI)
A0A0R4IR76 (/IPI)
A0A2R8RSG0 (/IPI)
A1A5T9 (/IPI)
A4IG25 (/IPI)
E7F4H0 (/IPI)
F1Q584 (/IPI)
O00327 (/IPI)
O00327 (/IPI)
O00327 (/IPI)
(9 more) |
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
10 | A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q9EPW1 (/ISS) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
10 | A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q9EPW1 (/ISS) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
9 | O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS) Q9I8T7 (/ISS) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
7 | O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O61734 (/IDA) Q9WTL8 (/IDA) |
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
7 | O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) Q8WYA1 (/IDA) Q9WTL8 (/IDA) |
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
7 | A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q8QGQ7 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
6 | O00327 (/ISA) O00327 (/ISA) O00327 (/ISA) O00327 (/ISA) O00327 (/ISA) Q8WYA1 (/ISA) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
6 | O00327 (/ISM) O00327 (/ISM) O00327 (/ISM) O00327 (/ISM) O00327 (/ISM) Q8WYA1 (/ISM) |
Showing 1 to 10 of 38 entries
There are 89 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
|
13 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q8QGQ7 (/ISS)
(3 more) |
Photoperiodism GO:0009648
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.
|
12 |
A0A0R4IH97 (/IEP)
A0A0R4IR76 (/IEP)
A0A2R8RSG0 (/IEP)
A1A5T9 (/IEP)
A4IG25 (/IEP)
E7F4H0 (/IEP)
F1Q584 (/IEP)
Q6NZ12 (/IEP)
Q7ZU37 (/IEP)
Q8JIG1 (/IEP)
(2 more) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
11 |
A0MLS5 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q6YGZ5 (/ISS)
Q6YGZ5 (/ISS)
Q6YGZ5 (/ISS)
Q8QGQ7 (/ISS)
Q91YA9 (/ISS)
Q9EPW1 (/ISS)
(1 more) |
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Showing 1 to 10 of 89 entries
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
|
11 |
A0MLS5 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O00327 (/ISS)
O88529 (/ISS)
O88529 (/ISS)
Q5R4T2 (/ISS)
Q91YA9 (/ISS)
(1 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
9 | H0Y5R1 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) Q8WYA1 (/IDA) Q9EPW1 (/IDA) Q9WTL8 (/IDA) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
9 | A4IG25 (/IPI) E7F4H0 (/IPI) F1Q584 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) Q8JIG1 (/IPI) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
8 | A0A140VKD3 (/IDA) A0A140VKD3 (/IDA) A0A140VKD3 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
8 | A0A140VKD3 (/IDA) A0A140VKD3 (/IDA) A0A140VKD3 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
7 | O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O61734 (/TAS) Q9WTL8 (/TAS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
6 | A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS) |
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
4 | A4IG25 (/IDA) E7F4H0 (/IDA) F1Q584 (/IDA) Q8JIG1 (/IDA) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
3 | Q7ZU37 (/IDA) Q9I879 (/IDA) Q9WTL8 (/IDA) |
Showing 1 to 10 of 20 entries