The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aminomethyltransferase fragment
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Aminomethyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aminomethyltransferase activity GO:0004047
Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
8 O14110 (/ISS) P25285 (/ISS) Q5BII9 (/ISS) Q8CFA2 (/ISS) Q8CFA2 (/ISS) Q95U61 (/ISS) Q9TSZ7 (/ISS) Q9VKR4 (/ISS)
Aminomethyltransferase activity GO:0004047
Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
2 P48728 (/IMP) P48728 (/IMP)
Aminomethyltransferase activity GO:0004047
Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
2 Q8CFA2 (/ISO) Q8CFA2 (/ISO)
Aminomethyltransferase activity GO:0004047
Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
2 P48728 (/TAS) P48728 (/TAS)
Aminomethyltransferase activity GO:0004047
Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
1 P28337 (/IDA)
Aminomethyltransferase activity GO:0004047
Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
1 C8VSU4 (/RCA)
Glycine dehydrogenase (decarboxylating) activity GO:0004375
Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.
1 A0A1D8PPW9 (/NAS)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 O14110 (/ISS)
Lipoic acid binding GO:0031405
Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid.
1 P25285 (/IDA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glycine metabolic process GO:0006544
The chemical reactions and pathways involving glycine, aminoethanoic acid.
7 P48015 (/IMP) P48015 (/IMP) P48015 (/IMP) P48015 (/IMP) P48015 (/IMP) P48015 (/IMP) P48015 (/IMP)
Glycine catabolic process GO:0006546
The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid.
7 P48015 (/IC) P48015 (/IC) P48015 (/IC) P48015 (/IC) P48015 (/IC) P48015 (/IC) P48015 (/IC)
One-carbon metabolic process GO:0006730
The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
7 P48015 (/IGI) P48015 (/IGI) P48015 (/IGI) P48015 (/IGI) P48015 (/IGI) P48015 (/IGI) P48015 (/IGI)
One-carbon metabolic process GO:0006730
The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
7 P48015 (/IMP) P48015 (/IMP) P48015 (/IMP) P48015 (/IMP) P48015 (/IMP) P48015 (/IMP) P48015 (/IMP)
Glycine decarboxylation via glycine cleavage system GO:0019464
The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.
5 O14110 (/ISS) P25285 (/ISS) Q8CFA2 (/ISS) Q8CFA2 (/ISS) Q9TSZ7 (/ISS)
Glycine catabolic process GO:0006546
The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid.
3 Q5BII9 (/ISS) Q95U61 (/ISS) Q9VKR4 (/ISS)
Glycine catabolic process GO:0006546
The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid.
3 P25285 (/TAS) P48728 (/TAS) P48728 (/TAS)
Glycine decarboxylation via glycine cleavage system GO:0019464
The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.
2 P48728 (/IMP) P48728 (/IMP)
Glycine decarboxylation via glycine cleavage system GO:0019464
The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.
2 Q8CFA2 (/ISO) Q8CFA2 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 O65396 (/IEP) O65396 (/IEP)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
1 C8VSU4 (/RCA)
Glycine decarboxylation via glycine cleavage system GO:0019464
The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.
1 P28337 (/IDA)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
11 A0A024R2U7 (/IDA) A0A024R2U7 (/IDA) A0A1B0GTB6 (/IDA) A0A1B0GVP5 (/IDA) B3KTU4 (/IDA) H0Y695 (/IDA) O65396 (/IDA) O65396 (/IDA) P25285 (/IDA) P48728 (/IDA)
(1 more)
Glycine cleavage complex GO:0005960
A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.
11 O14110 (/ISS) P48015 (/ISS) P48015 (/ISS) P48015 (/ISS) P48015 (/ISS) P48015 (/ISS) P48015 (/ISS) P48015 (/ISS) Q5BII9 (/ISS) Q95U61 (/ISS)
(1 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 O14110 (/HDA) P48015 (/HDA) P48015 (/HDA) P48015 (/HDA) P48015 (/HDA) P48015 (/HDA) P48015 (/HDA) P48015 (/HDA) Q8CFA2 (/HDA) Q8CFA2 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 A0A024R2U7 (/IDA) A0A024R2U7 (/IDA) A0A1B0GTB6 (/IDA) A0A1B0GVP5 (/IDA) B3KTU4 (/IDA) H0Y695 (/IDA) P48728 (/IDA) P48728 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P28337 (/IC) P48728 (/IC) P48728 (/IC)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P25285 (/TAS) P48728 (/TAS) P48728 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q8CFA2 (/ISO) Q8CFA2 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8CFA2 (/ISO) Q8CFA2 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 P48728 (/TAS) P48728 (/TAS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
2 O65396 (/IDA) O65396 (/IDA)
Chloroplast thylakoid GO:0009534
Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
2 O65396 (/IDA) O65396 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
2 O65396 (/IDA) O65396 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
2 O65396 (/IDA) O65396 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 O65396 (/IDA) O65396 (/IDA)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
2 O65396 (/IDA) O65396 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
2 O65396 (/IDA) O65396 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P25285 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 O14110 (/IC)
Glycine cleavage complex GO:0005960
A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.
1 P49364 (/IDA)
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