×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 4.10.1240.10

GPCR, family 2, extracellular hormone receptor domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
GPCR, family 2, extracellular hormone receptor domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Adhesion G protein-coupled receptor L2
613
3D
 4dlqA01 - 75.8
2
Adhesion G protein-coupled receptor B2
611
3D
 4dloB01 - 84.8
3
Putative cadherin EGF LAG seven-pass G-type receptor 2
373 - - 71.3
4
Adhesion G protein-coupled receptor L3
298 - - 71.2
5
Parathyroid hormone/parathyroid hormone-related peptide receptor
187
3D
 3l2jB02 - 80.0
6
corticotropin-releasing factor receptor 2 isoform X2
169
3D
 2jndA00 - 42.8
7
Corticotropin-releasing factor receptor 1
142
3D
 3ehuB03 - 76.3
8
pituitary adenylate cyclase-activating polypeptide type I receptor
117 - - 74.6
9
Glucagon receptor
109
3D
 4lf3F00 - 87.7
11
Calcitonin gene-related peptide type 1 receptor
105
3D
 3n7sB00 - 74.5
12
Calcitonin receptor
99
3D
 5ii0C00 - 71.6
10
Cadherin EGF LAG seven-pass G-type receptor 3
98 - - 46.1
13
Glucagon like peptide 1 receptor
98
3D
 5e94H00 - 71.5
14
Growth hormone-releasing hormone receptor 2
89
3D
 2xdgB01 - 86.0
15
Vasoactive intestinal polypeptide receptor 2
86 - - 66.7
16
Vasoactive intestinal peptide receptor 1
78 - - 91.4
17
Glucagon like peptide 2 receptor
61 - - 84.0
18
Secretin receptor
58 - - 86.2
19
Gastric inhibitory polypeptide receptor
47
3D
 4hj0B00 - 63.7
20
Adhesion G protein-coupled receptor F3
43 - - 14.6
21
Cadherin EGF LAG seven-pass G-type receptor
40 - - 93.9
22
Adenylate cyclase-activating polypeptide 1a
pituitary
33 - - 75.1
23
Uncharacterized protein, isoform B
33 - - 80.1
24
latrophilin Cirl isoform X1
32 - - 72.9
25
Corticotropin releasing hormone receptor 2
22 - - 59.3
26
Blast:Peroxidasin homolog
17 - - 54.8
27
Pituitary adenylate cyclase-activating polypeptide type I receptor isoform A
16 - - 9.2
28
FlaMIngo
Cadherin plus 7TM domain
15 - - 17.6
29
PDF receptor isoform X3
13 - - 81.3
30
Vasoactive intestinal polypeptide receptor
11 - - 46.4
31
Growth hormone-releasing hormone receptor a
10 - - 79.0
32
Cadherin EGF LAG seven-pass G-type receptor 3
8 - - 40.0
34
Diuretic hormone 31 receptor, isoform B
7 - - 16.1
35
Glucagon receptor a
7 - - 10.4
36
Adhesion G protein-coupled receptor A2
7 - - 64.2
37
Latrophilin-like protein 1
7 - - 82.7
33
LOC100145780 protein
7 - - 88.6
38
Vasoactive intestinal peptide receptor 2
5 - - 52.5
40
Hector, isoform A
4 - - 6.5
39
Corticotropin-releasing hormone receptor 2
4 - - 58.8
42
Parathyroid hormone receptor-like protein bf98C
3 - - 5.6
41
Putative diuretic hormone 44 receptor
3 - - 47.2
44
Uncharacterized protein
2 - - 34.0
49
SEcretin/class B GPCR
2 - - 21.5
56
Putative g protein-coupled receptor
2 - - 0.0
68
Gastric inhibitory polypeptide receptor
2 - - 24.3
55
Uncharacterized protein
2 - - 0.0
57
Latrophilin-like protein LAT-2
2 - - 19.5
61
Adhesion G protein-coupled receptor L1
2 - - 0.0
47
Parathyroid hormone receptor like 2
2 - - 40.8
63
Contactin-6
2 - - 0.0
46
Diuretic hormone receptor precursor, putative
2 - - 39.3
59
adhesion G protein-coupled receptor L3
2 - - 7.4
54
Adenylate cyclase-activating polypeptide 1
pituitary
2 - - 0.0
45
Calcitonin gene-related peptide type 1 receptor-like Protein
2 - - 36.2
62
Uncharacterized protein
2 - - 2.1
50
Glucagon-like peptide 1 receptor
2 - - 9.5
66
Receptor-type tyrosine-protein phosphatase F
2 - - 0.0
43
Parathyroid hormone 1 receptor
2 - - 34.9
65
Adhesion G protein-coupled receptor L3
2 - - 2.1
58
Uncharacterized protein
2 - - 40.4
67
Adhesion G protein-coupled receptor L3
2 - - 0.0
51
Glucagon receptor a
2 - - 0.0
53
PDF receptor-like Protein
2 - - 0.0
64
Adhesion G protein-coupled receptor L2
2 - - 6.3
52
Secretin receptor
2 - - 0.0
48
Uncharacterized protein
2 - - 18.7
60
Adhesion G protein-coupled receptor B3
2 - - 0.0
70
Uncharacterized protein
1 - - 0.0
80
Uncharacterized protein
1 - - 0.0
79
Uncharacterized protein
1 - - 0.0
74
Calcitonin receptor, putative
1 - - 0.0
89
Predicted protein
1 - - 0.0
84
C1A receptor, putative
1 - - 0.0
87
Uncharacterized protein
1 - - 0.0
77
Uncharacterized protein
1 - - 0.0
75
Uncharacterized protein
1 - - 0.0
85
Predicted protein
1 - - 0.0
86
Pituitary adenylate cyclase-activating polypeptide type I receptor
1 - - 0.0
76
Uncharacterized protein
1 - - 0.0
82
Uncharacterized protein
1 - - 0.0
72
Uncharacterized protein
1 - - 0.0
83
Uncharacterized protein
Fragment
1 - - 0.0
73
Uncharacterized protein
1 - - 0.0
71
Uncharacterized protein
1 - - 0.0
90
Uncharacterized protein
1 - - 0.0
81
Uncharacterized protein
1 - - 0.0
78
Uncharacterized protein
1 - - 0.0
69
C1A receptor, putative
1 - - 0.0
88
Uncharacterized protein
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...