The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"TSP type-3 repeat
".
FunFam 1: Thrombospondin 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 54 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
10 | P07996 (/IPI) P35441 (/IPI) P35442 (/IPI) P35443 (/IPI) P35444 (/IPI) P49747 (/IPI) Q03350 (/IPI) Q9R0G6 (/IPI) Q9Z1T2 (/IPI) Q9Z1T2 (/IPI) |
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
8 | F1SS26 (/RCA) P07996 (/RCA) P35441 (/RCA) P35442 (/RCA) P49746 (/RCA) P49747 (/RCA) Q9Z1T2 (/RCA) Q9Z1T2 (/RCA) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
7 | B7Z030 (/IDA) P07996 (/IDA) P35443 (/IDA) P49746 (/IDA) P49747 (/IDA) Q968S4 (/IDA) Q9VM97 (/IDA) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
5 | P35441 (/ISO) Q05895 (/ISO) Q9R0G6 (/ISO) Q9Z1T2 (/ISO) Q9Z1T2 (/ISO) |
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
|
4 | P35441 (/ISO) Q9R0G6 (/ISO) Q9Z1T2 (/ISO) Q9Z1T2 (/ISO) |
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
|
3 | P07996 (/IDA) P35444 (/IDA) P49744 (/IDA) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
3 | P35441 (/ISO) Q9Z1T2 (/ISO) Q9Z1T2 (/ISO) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
3 | Q9R0G6 (/ISO) Q9Z1T2 (/ISO) Q9Z1T2 (/ISO) |
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
3 | Q9R0G6 (/ISO) Q9Z1T2 (/ISO) Q9Z1T2 (/ISO) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
3 | Q8JGW0 (/NAS) Q8JHW2 (/NAS) Q8JHW2 (/NAS) |
Showing 1 to 10 of 54 entries
There are 205 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
7 | A0A0G2JV24 (/IDA) D4A2G6 (/IDA) M0R979 (/IDA) P07996 (/IDA) P35441 (/IDA) P35442 (/IDA) Q71SA3 (/IDA) |
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
|
5 | P07996 (/ISS) P35443 (/ISS) P49744 (/ISS) Q28178 (/ISS) Q3SWW8 (/ISS) |
Behavioral response to pain GO:0048266
Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
|
4 | P35441 (/IMP) P49744 (/IMP) Q9Z1T2 (/IMP) Q9Z1T2 (/IMP) |
Behavioral response to pain GO:0048266
Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
|
4 | P07996 (/ISS) P35443 (/ISS) Q28178 (/ISS) Q3SWW8 (/ISS) |
Growth plate cartilage development GO:0003417
The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.
|
3 | P35441 (/IGI) Q05895 (/IGI) Q9R0G6 (/IGI) |
Growth plate cartilage development GO:0003417
The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.
|
3 | P35441 (/IMP) Q05895 (/IMP) Q9R0G6 (/IMP) |
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
3 | B7Z030 (/IMP) Q968S4 (/IMP) Q9VM97 (/IMP) |
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
3 | A0A0G2JV24 (/IMP) M0R979 (/IMP) Q71SA3 (/IMP) |
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
|
3 | B7Z030 (/IMP) Q968S4 (/IMP) Q9VM97 (/IMP) |
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
3 | P07996 (/IMP) P35441 (/IMP) Q03350 (/IMP) |
Showing 1 to 10 of 205 entries
There are 43 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
9 | A0A0G2JV24 (/IDA) M0R979 (/IDA) P07996 (/IDA) P35441 (/IDA) P35443 (/IDA) Q71SA3 (/IDA) Q9R0G6 (/IDA) Q9Z1T2 (/IDA) Q9Z1T2 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
8 | P07996 (/ISS) P35443 (/ISS) P35448 (/ISS) P49744 (/ISS) Q06441 (/ISS) Q28178 (/ISS) Q3SWW8 (/ISS) Q8JGW0 (/ISS) |
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
|
8 | P07996 (/ISS) P35443 (/ISS) P35448 (/ISS) P49744 (/ISS) Q06441 (/ISS) Q28178 (/ISS) Q3SWW8 (/ISS) Q8JGW0 (/ISS) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
6 | P07996 (/HDA) P35441 (/HDA) P35442 (/HDA) P49746 (/HDA) Q9Z1T2 (/HDA) Q9Z1T2 (/HDA) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
6 | B7Z030 (/IDA) P35444 (/IDA) Q968S4 (/IDA) Q9VM97 (/IDA) Q9Z1T2 (/IDA) Q9Z1T2 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
5 | P07996 (/TAS) P35442 (/TAS) P35443 (/TAS) P49746 (/TAS) P49747 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
5 | P07996 (/HDA) P35441 (/HDA) P49747 (/HDA) Q03350 (/HDA) Q9R0G6 (/HDA) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
5 | P35443 (/ISS) P49744 (/ISS) Q06441 (/ISS) Q3SWW8 (/ISS) Q8JGW0 (/ISS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
4 | P49744 (/ISS) Q06441 (/ISS) Q3SWW8 (/ISS) Q8JGW0 (/ISS) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
4 | B7Z030 (/IDA) Q968S4 (/IDA) Q9R0G6 (/IDA) Q9VM97 (/IDA) |
Showing 1 to 10 of 43 entries