The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Ring Box Chain A; domain 5
".
FunFam 1: Putative Cullin-1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
35 |
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
(25 more) |
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
|
46 |
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
(36 more) |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
|
35 |
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
(25 more) |
NIK/NF-kappaB signaling GO:0038061
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
|
28 |
F1Q7M5 (/TAS)
F1QV12 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(18 more) |
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
SCF complex assembly GO:0010265
The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
23 |
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
(13 more) |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Stress-activated MAPK cascade GO:0051403
A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Intrinsic apoptotic signaling pathway GO:0097193
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Regulation of mitotic cell cycle phase transition GO:1901990
Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
12 |
Q9WTX6 (/IC)
Q9WTX6 (/IC)
Q9WTX6 (/IC)
Q9WTX6 (/IC)
Q9WTX6 (/IC)
Q9WTX6 (/IC)
Q9WTX6 (/IC)
Q9WTX6 (/IC)
Q9WTX6 (/IC)
Q9WTX6 (/IC)
(2 more) |
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
|
12 |
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
Q9WTX6 (/IGI)
(2 more) |
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
12 |
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
(2 more) |
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
12 |
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
(2 more) |
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
12 |
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
Q9WTX6 (/IMP)
(2 more) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
12 |
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
(2 more) |
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
|
12 |
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
(2 more) |
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
5 | F1Q7M5 (/IMP) F1QV12 (/IMP) Q6NYS3 (/IMP) Q7ZVR2 (/IMP) Q802D4 (/IMP) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
|
58 |
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
Q13616 (/ISS)
(48 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
35 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(25 more) |
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
|
35 |
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
(25 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
23 |
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
Q13616 (/TAS)
(13 more) |
Cullin-RING ubiquitin ligase complex GO:0031461
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
|
23 |
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
Q13616 (/IDA)
(13 more) |
Parkin-FBXW7-Cul1 ubiquitin ligase complex GO:1990452
A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein.
|
23 |
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
Q13616 (/IPI)
(13 more) |
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
|
12 |
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
(2 more) |
Cullin-RING ubiquitin ligase complex GO:0031461
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
|
12 |
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
(2 more) |
Parkin-FBXW7-Cul1 ubiquitin ligase complex GO:1990452
A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein.
|
12 |
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
Q9WTX6 (/ISO)
(2 more) |