The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"CRIB domain
".
FunFam 1: Non-specific serine/threonine protein kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 35 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
25 |
A0A0R4IC19 (/IPI)
A0A0R4IH73 (/IPI)
O75914 (/IPI)
O75914 (/IPI)
O75914 (/IPI)
O75914 (/IPI)
O75914 (/IPI)
O75914 (/IPI)
O75914 (/IPI)
O88643 (/IPI)
(15 more) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
16 |
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
(6 more) |
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
|
16 |
Q61036 (/ISS)
Q62829 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL4 (/ISS)
(6 more) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
14 |
B7Z0W0 (/IDA)
P35465 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13177 (/IDA)
Q13177 (/IDA)
(4 more) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
11 |
O88643 (/IDA)
P35465 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q61036 (/IDA)
Q62829 (/IDA)
(1 more) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
9 | B7Z0W0 (/ISS) E2REH3 (/ISS) F7AM77 (/ISS) O88643 (/ISS) Q08E52 (/ISS) Q24190 (/ISS) Q24213 (/ISS) Q8CIN4 (/ISS) Q9VI13 (/ISS) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
8 | Q13153 (/EXP) Q13153 (/EXP) Q13153 (/EXP) Q13153 (/EXP) Q13153 (/EXP) Q13153 (/EXP) Q13177 (/EXP) Q13177 (/EXP) |
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
|
7 | O75914 (/IDA) O75914 (/IDA) O75914 (/IDA) O75914 (/IDA) O75914 (/IDA) O75914 (/IDA) O75914 (/IDA) |
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
6 | Q13153 (/IPI) Q13153 (/IPI) Q13153 (/IPI) Q13153 (/IPI) Q13153 (/IPI) Q13153 (/IPI) |
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
|
6 | B7Z0W0 (/IPI) Q13177 (/IPI) Q13177 (/IPI) Q24190 (/IPI) Q24213 (/IPI) Q9VI13 (/IPI) |
Showing 1 to 10 of 35 entries
There are 180 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
|
22 |
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
Q62829 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
(12 more) |
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
|
22 |
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
Q62829 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
(12 more) |
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
22 |
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
O75914 (/ISS)
Q62829 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
(12 more) |
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
|
16 |
Q61036 (/ISS)
Q62829 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL3 (/ISS)
Q7YQL4 (/ISS)
(6 more) |
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
|
15 |
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
(5 more) |
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
|
15 |
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
(5 more) |
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
|
15 |
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
(5 more) |
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
13 |
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
(3 more) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
10 | P35465 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13177 (/IDA) Q13177 (/IDA) Q62829 (/IDA) |
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
9 | A0A0R4IRH8 (/IGI) A5WVS2 (/IGI) A5WVS3 (/IGI) A5X7A3 (/IGI) Q4V9B9 (/IGI) Q502N8 (/IGI) Q66IB7 (/IGI) Q6DG42 (/IGI) Q8AW67 (/IGI) |
Showing 1 to 10 of 180 entries
There are 64 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
18 |
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
(8 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
17 |
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
B3KNX7 (/IDA)
B3KNX7 (/IDA)
P35465 (/IDA)
Q13153 (/IDA)
(7 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
15 |
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
A0A024R5P0 (/IDA)
B3KNX7 (/IDA)
B3KNX7 (/IDA)
P35465 (/IDA)
Q13153 (/IDA)
(5 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
15 |
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
O75914 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
Q13153 (/TAS)
(5 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
13 |
B7Z0W0 (/IDA)
O88643 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13153 (/IDA)
Q13177 (/IDA)
Q13177 (/IDA)
(3 more) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
7 | P35465 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
6 | Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) |
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
|
6 | Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
6 | Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) Q13153 (/IDA) |
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
|
6 | Q13153 (/ISS) Q13153 (/ISS) Q13153 (/ISS) Q13153 (/ISS) Q13153 (/ISS) Q13153 (/ISS) |
Showing 1 to 10 of 64 entries