The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
5'-Nucleotidase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: NT5E isoform 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
5'-nucleotidase activity GO:0008253
Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
4 P21588 (/IDA) P21589 (/IDA) Q7K0L5 (/IDA) Q8SZY4 (/IDA)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
2 Q61503 (/ISO) Q61503 (/ISO)
5'-nucleotidase activity GO:0008253
Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
2 Q61503 (/IMP) Q61503 (/IMP)
5'-nucleotidase activity GO:0008253
Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
2 Q61503 (/ISO) Q61503 (/ISO)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
1 P21588 (/IDA)
5'-nucleotidase activity GO:0008253
Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
1 P21589 (/TAS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
AMP catabolic process GO:0006196
The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate.
2 Q61503 (/IMP) Q61503 (/IMP)
AMP catabolic process GO:0006196
The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate.
2 Q61503 (/ISO) Q61503 (/ISO)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
2 Q61503 (/ISO) Q61503 (/ISO)
Adenosine metabolic process GO:0046085
The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
2 Q61503 (/ISO) Q61503 (/ISO)
Adenosine biosynthetic process GO:0046086
The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
2 Q61503 (/IMP) Q61503 (/IMP)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
2 Q5PNP4 (/IDA) Q7SXU4 (/IDA)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
2 Q61503 (/IMP) Q61503 (/IMP)
Purine nucleotide catabolic process GO:0006195
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
1 P21589 (/TAS)
AMP catabolic process GO:0006196
The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate.
1 P21588 (/IDA)
DNA metabolic process GO:0006259
Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
1 P21589 (/TAS)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
1 P21589 (/IDA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P21588 (/IEP)
Response to aluminum ion GO:0010044
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.
1 P21588 (/IEP)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 Q8SZY4 (/IDA)
NAD metabolic process GO:0019674
The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
1 P21589 (/TAS)
Adenosine metabolic process GO:0046085
The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
1 P21588 (/IDA)
Pyrimidine nucleoside catabolic process GO:0046135
The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
1 P21589 (/TAS)
Positive regulation of lipid biosynthetic process GO:0046889
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
1 P21588 (/IEP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P21588 (/IDA) P21589 (/IDA) Q61503 (/IDA) Q61503 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q61503 (/ISO) Q61503 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q61503 (/ISO) Q61503 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q61503 (/ISO) Q61503 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q61503 (/ISO) Q61503 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q61503 (/IDA) Q61503 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
2 Q61503 (/ISO) Q61503 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P21589 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P21589 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P21589 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P21589 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P21588 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P21589 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P21588 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P21589 (/HDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 P21588 (/IDA)
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