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We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
960
3D
1qxpB02 - 97.3
6
619
3D
5qc4B00 - 90.4
2
612 - - 71.3
3
582
3D
5k16B00 - 74.7
4
503 - - 80.0
5
414 - - 84.8
7
367 - - 75.9
8
355 - - 72.2
9
354
3D
2vhfB00 - 86.0
10
351 - - 92.6
13
326
3D
6ml1B00 - 62.3
11
317 - - 72.4
12
315 - - 43.5
14
286 - - 69.6
15
273 - - 76.3
16
268 - - 81.9
17
252 - - 85.5
31
251
3D
6ay2B00 - 94.1
18
251 - - 72.9
19
231 - - 73.7
21
231
3D
2cb5B01 - 91.9
20
230 - - 47.1
24
222
3D
6dgfA00 - 77.0
23
219
3D
1s4vB00 - 90.9
22
218 - - 93.1
25
210
3D
3n3kA00 - 77.9
26
206 - - 89.0
27
204 - - 83.0
28
203 - - 73.9
29
198 - - 77.9
30
197 - - 71.2
32
196
3D
6iinB00 - 89.8
33
175
3D
3ihpB03 - 67.3
34
167 - - 50.6
36
160
3D
3ch3X00 - 75.7
35
159 - - 76.4
37
150 - - 79.6
38
146 - - 78.0
39
144 - - 95.4
40
142 - - 59.7
41
137 - - 84.2
42
131 - - 74.9
43
131 - - 89.9
44
130 - - 82.9
45
125 - - 76.9
47
115 - - 70.4
46
115 - - 86.8
48
113 - - 79.1
49
111 - - 87.8
50
110
3D
1m6dB00 - 72.5
51
101 - - 42.9
52
98 - - 54.6
58
97
3D
3mtnC00 - 76.4
53
96 - - 69.6
54
95 - - 93.4
55
94 - - 84.9
57
90 - - 89.7
60
90
3D
1ef7B00 - 84.0
56
90 - - 73.0
138
87
3D
6exqB00 - 91.8
59
87 - - 70.9
61
85 - - 44.4
62
84
3D
3pdfA02 - 72.6
63
81 - - 77.4
64
81 - - 87.0
65
80 - - 50.8
66
79 - - 79.3
67
77 - - 89.4
69
76 - - 26.1
68
76 - - 76.0
70
74 - - 80.3
71
71 - - 51.1
72
70 - - 75.7
74
67
3D
6czsA00 - 72.5
86
67
3D
2oulA00 - 37.6
73
66 - - 80.4
75
65 - - 67.9
76
64 - - 53.9
77
63 - - 60.4
78
62 - - 69.6
79
59 - - 82.9
80
58 - - 72.4
81
56 - - 90.3
82
55 - - 36.4
91
53
3D
3gcbA01 - 83.5
84
52 - - 74.8
83
52 - - 83.7
85
51 - - 69.2
96
50
3D
4n4zA00 - 94.1
88
50
3D
5chvB00 - 73.1
87
50 - - 85.6
204
48
3D
9papA00 - 86.2
89
45 - - 77.9
90
44 - - 94.6
92
43 - - 89.0
93
42 - - 71.6
95
42 - - 71.6
94
42 - - 35.3
97
40 - - 31.0
99
38 - - 85.3
98
Pcalp
38 - - 27.0
101
36 - - 71.1
100
36 - - 77.1
102
35 - - 80.4
103
35 - - 93.6
104
34 - - 94.7
105
34 - - 72.5
106
34 - - 51.6
107
33 - - 3.8
108
33 - - 83.2
109
33 - - 94.8
110
31 - - 61.5
111
30 - - 28.0
168
30
3D
6r9qA01 - 65.1
113
29 - - 75.2
114
29 - - 97.5
112
29 - - 71.7
190
28
3D
6aqrA02 - 17.4
126
28
3D
6ffaA00 - 25.3
115
28 - - 72.2
117
27 - - 87.4
116
27 - - 86.3
118
26 - - 64.6
119
26 - - 81.3
121
25 - - 72.5
120
25 - - 28.1
122
25 - - 86.3
128
24 - - 79.7
127
24 - - 75.7
130
24 - - 84.8
125
24 - - 47.8
129
24 - - 88.6
123
24 - - 40.1
124
24 - - 65.0
131
23 - - 79.4
133
22 - - 58.8
134
22 - - 73.7
132
22 - - 63.1
136
21 - - 72.3
135
21 - - 69.0
137
21 - - 13.9
139
20 - - 7.6
140
19 - - 66.2
148
18
3D
3zuaA01 - 42.2
141
18 - - 17.7
142
18 - - 74.2
147
17 - - 11.7
156
17
3D
1vjvA01 - 85.6
150
17 - - 93.8
143
17 - - 86.9
555
17
3D
6bkjD02 - 51.7
144
17 - - 74.6
149
17 - - 7.2
146
17 - - 64.8
145
17 - - 84.0
153
16 - - 26.6
154
16 - - 6.8
152
16 - - 75.2
155
16 - - 77.9
151
16 - - 12.2
159
15 - - 69.6
160
15 - - 10.1
157
15 - - 18.4
158
15 - - 81.8
161
15 - - 76.0
164
14 - - 68.2
163
14 - - 82.3
162
14 - - 64.5
166
14 - - 62.8
165
14 - - 76.6
167
14 - - 96.0
177
13 - - 84.3
169
13 - - 9.0
171
13 - - 85.5
174
13 - - 70.8
173
13 - - 21.8
172
13 - - 93.2
176
13 - - 70.4
175
13 - - 30.4
170
13 - - 2.8
178
12 - - 78.4
180
12 - - 64.5
179
12 - - 11.7
188
11 - - 14.8
181
11 - - 13.5
187
11 - - 10.8
186
11 - - 12.4
185
11 - - 33.8
184
11 - - 27.0
183
11 - - 18.2
191
Human disease gene
11 - - 40.6
189
11 - - 73.4
182
11 - - 17.0
194
10 - - 59.0
216
10
3D
4msxA02 - 2.1
193
10 - - 31.7
205
10 - - 62.8
200
10 - - 17.0
206
10 - - 67.3
192
10 - - 60.3
199
10 - - 71.8
196
10 - - 88.0
202
10 - - 70.2
203
10 - - 35.2
195
10 - - 72.9
201
10 - - 12.3
197
10 - - 33.9
208
10 - - 77.0
198
10 - - 74.4
207
10 - - 74.2
210
9 - - 15.6
215
9 - - 1.1
214
9 - - 19.5
209
9 - - 39.0
213
9 - - 22.6
212
9 - - 69.9
219
9 - - 96.5
408
9
3D
1o0eB00 - 58.6
218
9 - - 80.5
211
9 - - 89.7
217
9 - - 19.3
229
8 - - 8.9
222
8 - - 59.4
231
8 - - 77.9
224
8 - - 34.1
223
8 - - 12.6
220
8 - - 53.0
225
8 - - 8.8
226
8 - - 10.9
227
8 - - 29.6
230
8 - - 34.9
221
8 - - 79.6
228
8 - - 13.7
232
8 - - 82.3
246
7 - - 6.2
238
7 - - 13.7
258
7 - - 45.3
251
7 - - 10.7
245
7 - - 10.0
240
7 - - 0.0
244
7 - - 7.4
243
7 - - 64.2
237
7 - - 5.9
257
7 - - 67.7
249
7 - - 2.1
242
7 - - 79.6
236
7 - - 4.0
256
7 - - 46.0
248
7 - - 10.2
241
7 - - 72.3
255
7 - - 0.0
250
7 - - 8.4
235
7 - - 67.5
254
7 - - 1.9
234
7 - - 69.4
247
7 - - 8.0
233
7 - - 17.6
253
7 - - 6.5
239
7 - - 5.9
252
7 - - 9.0
283
6 - - 5.7
268
6 - - 3.8
284
6 - - 85.8
276
6 - - 53.6
275
6 - - 0.4
270
6 - - 8.0
282
6 - - 8.3
261
6 - - 83.2
273
6 - - 2.5
267
6 - - 88.2
332
6
3D
1cs8A00 - 48.4
274
6 - - 5.7
272
6 - - 3.1
280
6 - - 0.0
279
6 - - 4.6
278
6 - - 18.4
266
6 - - 70.5
265
6 - - 74.9
260
6 - - 72.3
271
6 - - 9.1
263
6 - - 0.0
277
6 - - 5.9
264
6 - - 38.0
262
6 - - 86.2
269
6 - - 3.7
281
6 - - 2.6
259
6 - - 73.4
311
5 - - 0.0
298
5 - - 6.4
308
5 - - 6.7
289
5 - - 75.4
301
5 - - 55.1
318
5 - - 58.2
291
5 - - 73.4
297
5 - - 9.3
286
5 - - 5.7
307
5 - - 0.0
321
5 - - 69.0
285
5 - - 2.4
317
5 - - 41.8
287
5 - - 19.2
306
5 - - 34.1
310
5 - - 16.8
296
5 - - 4.3
315
5 - - 68.2
295
5 - - 2.3
316
5 - - 39.2
290
5 - - 74.4
305
5 - - 11.1
300
5 - - 36.3
288
5 - - 76.7
304
5 - - 4.0
293
5 - - 6.1
319
5 - - 75.1
294
5 - - 3.4
303
5 - - 9.8
312
5 - - 8.9
292
5 - - 72.3
314
5 - - 16.2
299
5 - - 47.0
302
5 - - 2.9
320
5 - - 57.7
313
5 - - 0.0
309
5 - - 0.0
341
4 - - 9.8
330
4 - - 58.7
335
4 - - 64.9
355
4 - - 69.0
327
4 - - 38.9
350
4 - - 38.0
356
4 - - 66.7
336
4 - - 28.6
348
4 - - 1.2
339
4 - - 56.5
328
4 - - 58.4
352
4 - - 41.5
334
4 - - 59.7
354
4 - - 68.4
353
4 - - 60.0
347
4 - - 7.9
333
4 - - 49.2
324
4 - - 0.0
351
4 - - 30.8
331
4 - - 67.4
345
4 - - 66.3
340
4 - - 0.0
323
4 - - 8.2
346
4 - - 12.6
322
4 - - 8.1
358
4 - - 74.2
338
4 - - 49.1
329
4 - - 57.0
326
4 - - 59.7
342
4 - - 4.6
349
4 - - 33.1
344
4 - - 72.7
357
4 - - 57.4
325
4 - - 17.7
343
4 - - 0.0
337
4 - - 62.6
406
3 - - 43.8
365
3 - - 0.0
395
3 - - 3.0
360
3 - - 42.8
390
3 - - 11.3
410
3 - - 56.7
371
3 - - 3.9
415
3 - - 75.8
378
3 - - 12.9
416
3 - - 38.0
387
3 - - 8.9
366
3 - - 8.2
396
3 - - 5.2
405
3 - - 40.2
400
3 - - 0.0
399
3 - - 0.0
369
3 - - 0.8
392
3 - - 71.4
362
3 - - 0.8
404
3 - - 8.2
403
3 - - 13.1
412
3 - - 61.1
359
3 - - 19.1
419
3 - - 73.3
381
3 - - 46.4
363
3 - - 0.0
393
3 - - 0.0
414
3 - - 71.7
377
3 - - 73.1
388
3 - - 3.4
409
3 - - 44.7
402
3 - - 7.4
420
3 - - 29.6
364
3 - - 1.1
394
3 - - 9.2
413
3 - - 68.6
382
3 - - 43.9
375
3 - - 72.0
389
3 - - 0.0
370
3 - - 4.2
411
3 - - 66.7
391
3 - - 73.4
361
3 - - 11.9
401
3 - - 56.1
398
3 - - 2.2
368
3 - - 10.4
383
3 - - 47.2
384
3 - - 29.9
376
3 - - 72.5
418
AFU_orthologue AFUA_2G08440
3 - - 41.2
380
3 - - 22.9
385
3 - - 0.5
379
3 - - 12.4
372
3 - - 42.2
407
3 - - 26.7
373
3 - - 63.4
397
3 - - 9.1
367
3 - - 6.4
386
3 - - 7.4
374
3 - - 12.5
417
3 - - 23.1
524
2 - - 11.7
551
2 - - 34.6
475
2 - - 17.0
489
2 - - 0.8
431
2 - - 36.4
470
2 - - 41.1
451
2 - - 0.0
424
2 - - 0.0
506
2 - - 4.0
482
2 - - 4.8
531
2 - - 0.0
545
2 - - 32.6
561
2 - - 42.3
540
2 - - 0.0
423
2 - - 22.5
510
2 - - 34.9
491
2 - - 0.0
461
2 - - 34.2
445
2 - - 0.0
523
2 - - 0.0
515
2 - - 28.8
440
2 - - 0.0
516
2 - - 31.3
483
2 - - 1.8
446
2 - - 0.0
546
2 - - 31.0
498
2 - - 8.7
468
2 - - 34.8
505
AFU_orthologue AFUA_5G13620
2 - - 0.0
429
2 - - 29.1
438
2 - - 3.1
500
2 - - 0.0
558
2 - - 37.2
522
2 - - 2.3
484
2 - - 5.8
529
2 - - 6.2
538
2 - - 28.0
422
2 - - 0.0
476
2 - - 10.2
458
2 - - 12.9
426
2 - - 21.8
472
2 - - 12.2
504
2 - - 0.0
526
2 - - 1.4
480
2 - - 27.9
485
2 - - 0.5
479
2 - - 27.3
542
2 - - 0.0
519
2 - - 9.3
449
2 - - 6.2
503
2 - - 7.6
442
2 - - 0.0
549
2 - - 39.7
512
2 - - 39.3
544
2 - - 23.2
497
2 - - 2.2
473
2 - - 37.5
514
2 - - 49.2
467
2 - - 38.6
444
2 - - 0.0
486
2 - - 2.0
557
2 - - 20.2
520
AFU_orthologue AFUA_2G08440
2 - - 0.0
502
2 - - 5.5
443
2 - - 8.9
437
2 - - 0.5
525
2 - - 6.9
474
2 - - 17.6
513
2 - - 40.8
543
2 - - 38.7
457
2 - - 32.1
509
2 - - 36.6
425
2 - - 0.0
537
2 - - 38.1
465
2 - - 42.2
441
2 - - 0.0
495
AFU_orthologue AFUA_1G07555
2 - - 0.0
460
2 - - 36.1
490
2 - - 1.8
511
2 - - 40.6
541
2 - - 0.7
565
2 - - 44.8
560
2 - - 39.0
530
2 - - 8.9
455
2 - - 1.9
535
2 - - 18.4
427
2 - - 31.9
450
2 - - 0.0
471
2 - - 36.7
430
2 - - 36.4
508
2 - - 0.0
527
2 - - 13.3
550
2 - - 35.6
435
2 - - 0.6
436
2 - - 3.0
556
2 - - 35.0
487
2 - - 10.0
536
2 - - 20.9
501
2 - - 0.0
456
2 - - 20.4
478
2 - - 26.5
518
2 - - 10.9
448
2 - - 0.0
566
2 - - 39.3
466
2 - - 39.6
548
2 - - 32.3
496
2 - - 0.0
492
2 - - 11.6
462
2 - - 38.5
562
2 - - 41.0
499
2 - - 7.3
469
2 - - 40.6
428
2 - - 31.9
439
2 - - 2.5
452
2 - - 0.0
559
2 - - 41.2
481
2 - - 0.0
532
2 - - 37.4
552
2 - - 35.7
528
2 - - 0.0
539
2 - - 0.0
507
2 - - 2.2
432
2 - - 39.6
459
2 - - 34.3
534
2 - - 13.1
488
2 - - 11.3
563
2 - - 34.4
454
2 - - 0.0
421
2 - - 14.8
463
2 - - 37.0
477
2 - - 8.8
434
2 - - 36.5
493
2 - - 1.5
521
2 - - 0.0
554
2 - - 40.1
447
2 - - 10.6
553
2 - - 34.9
464
2 - - 40.8
517
2 - - 9.6
433
2 - - 42.4
494
2 - - 4.6
453
2 - - 0.0
547
2 - - 32.3
533
2 - - 1.9
564
2 - - 43.5
681
1 - - 0.0
816
1 - - 0.0
714
1 - - 0.0
898
1 - - 0.0
582
1 - - 0.0
652
1 - - 0.0
868
1 - - 0.0
628
1 - - 0.0
639
1 - - 0.0
607
1 - - 0.0
797
1 - - 0.0
589
1 - - 0.0
659
1 - - 0.0
773
1 - - 0.0
575
1 - - 0.0
632
1 - - 0.0
767
1 - - 0.0
883
1 - - 0.0
570
1 - - 0.0
744
1 - - 0.0
846
1 - - 0.0
786
1 - - 0.0
884
1 - - 0.0
591
1 - - 0.0
743
1 - - 0.0
805
1 - - 0.0
737
1 - - 0.0
774
1 - - 0.0
876
1 - - 0.0
709
1 - - 0.0
662
1 - - 0.0
822
1 - - 0.0
858
1 - - 0.0
692
1 - - 0.0
800
1 - - 0.0
838
1 - - 0.0
829
1 - - 0.0
669
1 - - 0.0
702
1 - - 0.0
699
1 - - 0.0
720
1 - - 0.0
757
1 - - 0.0
907
1 - - 0.0
713
1 - - 0.0
725
1 - - 0.0
694
1 - - 0.0
633
1 - - 0.0
851
1 - - 0.0
664
1 - - 0.0
726
1 - - 0.0
824
1 - - 0.0
772
1 - - 0.0
568
1 - - 0.0
598
1 - - 0.0
882
1 - - 0.0
647
1 - - 0.0
780
1 - - 0.0
875
1 - - 0.0
617
1 - - 0.0
889
1 - - 0.0
785
1 - - 0.0
870
1 - - 0.0
831
1 - - 0.0
583
1 - - 0.0
653
1 - - 0.0
806
1 - - 0.0
704
1 - - 0.0
779
1 - - 0.0
891
1 - - 0.0
621
1 - - 0.0
861
1 - - 0.0
654
1 - - 0.0
584
1 - - 0.0
845
1 - - 0.0
703
1 - - 0.0
712
1 - - 0.0
688
1 - - 0.0
749
1 - - 0.0
576
1 - - 0.0
840
1 - - 0.0
719
1 - - 0.0
742
1 - - 0.0
810
1 - - 0.0
693
1 - - 0.0
634
1 - - 0.0
677
1 - - 0.0
815
1 - - 0.0
823
1 - - 0.0
663
1 - - 0.0
897
1 - - 0.0
873
1 - - 0.0
608
1 - - 0.0
580
1 - - 0.0
867
1 - - 0.0
650
1 - - 0.0
627
1 - - 0.0
579
1 - - 0.0
783
1 - - 0.0
746
1 - - 0.0
844
1 - - 0.0
585
1 - - 0.0
655
1 - - 0.0
572
1 - - 0.0
635
1 - - 0.0
716
1 - - 0.0
814
1 - - 0.0
630
1 - - 0.0
671
1 - - 0.0
798
1 - - 0.0
768
1 - - 0.0
690
1 - - 0.0
738
1 - - 0.0
729
1 - - 0.0
802
1 - - 0.0
660
1 - - 0.0
857
1 - - 0.0
820
1 - - 0.0
695
1 - - 0.0
813
1 - - 0.0
641
1 - - 0.0
825
1 - - 0.0
665
1 - - 0.0
908
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