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We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
960
3D
1qxpB02 - 97.3
6
619
3D
5qc4B00 - 90.4
2
612 - - 71.3
3
582
3D
5k16B00 - 74.7
4
503 - - 80.0
5
414 - - 84.8
7
367 - - 75.9
8
355 - - 72.2
9
354
3D
2vhfB00 - 86.0
10
351 - - 92.6
13
326
3D
6ml1B00 - 62.3
11
317 - - 72.4
12
315 - - 43.5
14
286 - - 69.6
15
273 - - 76.3
16
268 - - 81.9
17
252 - - 85.5
31
251
3D
6ay2B00 - 94.1
18
251 - - 72.9
19
231 - - 73.7
21
231
3D
2cb5B01 - 91.9
20
230 - - 47.1
24
222
3D
6dgfA00 - 77.0
23
219
3D
1s4vB00 - 90.9
22
218 - - 93.1
25
210
3D
3n3kA00 - 77.9
26
206 - - 89.0
27
204 - - 83.0
28
203 - - 73.9
29
198 - - 77.9
30
197 - - 71.2
32
196
3D
6iinB00 - 89.8
33
175
3D
3ihpB03 - 67.3
34
167 - - 50.6
36
160
3D
3ch3X00 - 75.7
35
159 - - 76.4
37
150 - - 79.6
38
146 - - 78.0
39
144 - - 95.4
40
142 - - 59.7
41
137 - - 84.2
43
131 - - 89.9
42
131 - - 74.9
44
130 - - 82.9
45
125 - - 76.9
46
115 - - 86.8
47
115 - - 70.4
48
113 - - 79.1
49
111 - - 87.8
50
110
3D
1m6dB00 - 72.5
51
101 - - 42.9
52
98 - - 54.6
58
97
3D
3mtnC00 - 76.4
53
96 - - 69.6
54
95 - - 93.4
55
94 - - 84.9
57
90 - - 89.7
56
90 - - 73.0
60
90
3D
1ef7B00 - 84.0
59
87 - - 70.9
138
87
3D
6exqB00 - 91.8
61
85 - - 44.4
62
84
3D
3pdfA02 - 72.6
63
81 - - 77.4
64
81 - - 87.0
65
80 - - 50.8
66
79 - - 79.3
67
77 - - 89.4
69
76 - - 26.1
68
76 - - 76.0
70
74 - - 80.3
71
71 - - 51.1
72
70 - - 75.7
86
67
3D
2oulA00 - 37.6
74
67
3D
6czsA00 - 72.5
73
66 - - 80.4
75
65 - - 67.9
76
64 - - 53.9
77
63 - - 60.4
78
62 - - 69.6
79
59 - - 82.9
80
58 - - 72.4
81
56 - - 90.3
82
55 - - 36.4
91
53
3D
3gcbA01 - 83.5
84
52 - - 74.8
83
52 - - 83.7
85
51 - - 69.2
88
50
3D
5chvB00 - 73.1
87
50 - - 85.6
96
50
3D
4n4zA00 - 94.1
204
48
3D
9papA00 - 86.2
89
45 - - 77.9
90
44 - - 94.6
92
43 - - 89.0
93
42 - - 71.6
94
42 - - 35.3
95
42 - - 71.6
97
40 - - 31.0
98
Pcalp
38 - - 27.0
99
38 - - 85.3
101
36 - - 71.1
100
36 - - 77.1
103
35 - - 93.6
102
35 - - 80.4
106
34 - - 51.6
104
34 - - 94.7
105
34 - - 72.5
108
33 - - 83.2
109
33 - - 94.8
107
33 - - 3.8
110
31 - - 61.5
111
30 - - 28.0
168
30
3D
6r9qA01 - 65.1
114
29 - - 97.5
112
29 - - 71.7
113
29 - - 75.2
190
28
3D
6aqrA02 - 17.4
126
28
3D
6ffaA00 - 25.3
115
28 - - 72.2
116
27 - - 86.3
117
27 - - 87.4
118
26 - - 64.6
119
26 - - 81.3
121
25 - - 72.5
122
25 - - 86.3
120
25 - - 28.1
124
24 - - 65.0
127
24 - - 75.7
123
24 - - 40.1
129
24 - - 88.6
128
24 - - 79.7
125
24 - - 47.8
130
24 - - 84.8
131
23 - - 79.4
134
22 - - 73.7
133
22 - - 58.8
132
22 - - 63.1
136
21 - - 72.3
137
21 - - 13.9
135
21 - - 69.0
139
20 - - 7.6
140
19 - - 66.2
141
18 - - 17.7
148
18
3D
3zuaA01 - 42.2
142
18 - - 74.2
146
17 - - 64.8
156
17
3D
1vjvA01 - 85.6
144
17 - - 74.6
555
17
3D
6bkjD02 - 51.7
149
17 - - 7.2
150
17 - - 93.8
147
17 - - 11.7
143
17 - - 86.9
145
17 - - 84.0
154
16 - - 6.8
151
16 - - 12.2
155
16 - - 77.9
152
16 - - 75.2
153
16 - - 26.6
160
15 - - 10.1
158
15 - - 81.8
159
15 - - 69.6
157
15 - - 18.4
161
15 - - 76.0
165
14 - - 76.6
162
14 - - 64.5
163
14 - - 82.3
167
14 - - 96.0
164
14 - - 68.2
166
14 - - 62.8
170
13 - - 2.8
175
13 - - 30.4
172
13 - - 93.2
169
13 - - 9.0
173
13 - - 21.8
177
13 - - 84.3
174
13 - - 70.8
176
13 - - 70.4
171
13 - - 85.5
179
12 - - 11.7
178
12 - - 78.4
180
12 - - 64.5
183
11 - - 18.2
187
11 - - 10.8
188
11 - - 14.8
189
11 - - 73.4
185
11 - - 33.8
182
11 - - 17.0
181
11 - - 13.5
186
11 - - 12.4
191
Human disease gene
11 - - 40.6
184
11 - - 27.0
208
10 - - 77.0
192
10 - - 60.3
207
10 - - 74.2
203
10 - - 35.2
195
10 - - 72.9
198
10 - - 74.4
199
10 - - 71.8
200
10 - - 17.0
202
10 - - 70.2
197
10 - - 33.9
193
10 - - 31.7
205
10 - - 62.8
194
10 - - 59.0
206
10 - - 67.3
201
10 - - 12.3
196
10 - - 88.0
216
10
3D
4msxA02 - 2.1
408
9
3D
1o0eB00 - 58.6
209
9 - - 39.0
212
9 - - 69.9
215
9 - - 1.1
210
9 - - 15.6
217
9 - - 19.3
213
9 - - 22.6
218
9 - - 80.5
219
9 - - 96.5
214
9 - - 19.5
211
9 - - 89.7
227
8 - - 29.6
223
8 - - 12.6
229
8 - - 8.9
228
8 - - 13.7
232
8 - - 82.3
222
8 - - 59.4
225
8 - - 8.8
220
8 - - 53.0
230
8 - - 34.9
231
8 - - 77.9
221
8 - - 79.6
226
8 - - 10.9
224
8 - - 34.1
248
7 - - 10.2
249
7 - - 2.1
250
7 - - 8.4
237
7 - - 5.9
233
7 - - 17.6
239
7 - - 5.9
238
7 - - 13.7
247
7 - - 8.0
255
7 - - 0.0
243
7 - - 64.2
252
7 - - 9.0
235
7 - - 67.5
240
7 - - 0.0
258
7 - - 45.3
242
7 - - 79.6
253
7 - - 6.5
257
7 - - 67.7
245
7 - - 10.0
254
7 - - 1.9
246
7 - - 6.2
241
7 - - 72.3
236
7 - - 4.0
256
7 - - 46.0
244
7 - - 7.4
234
7 - - 69.4
251
7 - - 10.7
274
6 - - 5.7
332
6
3D
1cs8A00 - 48.4
264
6 - - 38.0
281
6 - - 2.6
276
6 - - 53.6
266
6 - - 70.5
259
6 - - 73.4
284
6 - - 85.8
271
6 - - 9.1
261
6 - - 83.2
270
6 - - 8.0
283
6 - - 5.7
260
6 - - 72.3
275
6 - - 0.4
265
6 - - 74.9
272
6 - - 3.1
262
6 - - 86.2
279
6 - - 4.6
278
6 - - 18.4
269
6 - - 3.7
268
6 - - 3.8
282
6 - - 8.3
273
6 - - 2.5
280
6 - - 0.0
263
6 - - 0.0
267
6 - - 88.2
277
6 - - 5.9
317
5 - - 41.8
313
5 - - 0.0
294
5 - - 3.4
300
5 - - 36.3
318
5 - - 58.2
319
5 - - 75.1
286
5 - - 5.7
302
5 - - 2.9
320
5 - - 57.7
305
5 - - 11.1
312
5 - - 8.9
308
5 - - 6.7
309
5 - - 0.0
296
5 - - 4.3
315
5 - - 68.2
307
5 - - 0.0
291
5 - - 73.4
310
5 - - 16.8
303
5 - - 9.8
311
5 - - 0.0
287
5 - - 19.2
290
5 - - 74.4
304
5 - - 4.0
292
5 - - 72.3
295
5 - - 2.3
316
5 - - 39.2
288
5 - - 76.7
289
5 - - 75.4
298
5 - - 6.4
299
5 - - 47.0
321
5 - - 69.0
285
5 - - 2.4
306
5 - - 34.1
301
5 - - 55.1
297
5 - - 9.3
293
5 - - 6.1
314
5 - - 16.2
322
4 - - 8.1
358
4 - - 74.2
335
4 - - 64.9
325
4 - - 17.7
340
4 - - 0.0
353
4 - - 60.0
342
4 - - 4.6
357
4 - - 57.4
345
4 - - 66.3
330
4 - - 58.7
350
4 - - 38.0
327
4 - - 38.9
337
4 - - 62.6
348
4 - - 1.2
349
4 - - 33.1
333
4 - - 49.2
323
4 - - 8.2
347
4 - - 7.9
355
4 - - 69.0
339
4 - - 56.5
338
4 - - 49.1
329
4 - - 57.0
328
4 - - 58.4
352
4 - - 41.5
343
4 - - 0.0
356
4 - - 66.7
344
4 - - 72.7
351
4 - - 30.8
334
4 - - 59.7
324
4 - - 0.0
354
4 - - 68.4
331
4 - - 67.4
346
4 - - 12.6
341
4 - - 9.8
336
4 - - 28.6
326
4 - - 59.7
366
3 - - 8.2
409
3 - - 44.7
376
3 - - 72.5
412
3 - - 61.1
359
3 - - 19.1
396
3 - - 5.2
415
3 - - 75.8
384
3 - - 29.9
391
3 - - 73.4
407
3 - - 26.7
361
3 - - 11.9
403
3 - - 13.1
410
3 - - 56.7
371
3 - - 3.9
417
3 - - 23.1
364
3 - - 1.1
374
3 - - 12.5
381
3 - - 46.4
400
3 - - 0.0
394
3 - - 9.2
413
3 - - 68.6
402
3 - - 7.4
386
3 - - 7.4
419
3 - - 73.3
418
AFU_orthologue AFUA_2G08440
3 - - 41.2
405
3 - - 40.2
420
3 - - 29.6
385
3 - - 0.5
398
3 - - 2.2
399
3 - - 0.0
369
3 - - 0.8
406
3 - - 43.8
368
3 - - 10.4
382
3 - - 43.9
379
3 - - 12.4
378
3 - - 12.9
363
3 - - 0.0
380
3 - - 22.9
401
3 - - 56.1
397
3 - - 9.1
373
3 - - 63.4
377
3 - - 73.1
393
3 - - 0.0
414
3 - - 71.7
367
3 - - 6.4
360
3 - - 42.8
383
3 - - 47.2
370
3 - - 4.2
411
3 - - 66.7
404
3 - - 8.2
387
3 - - 8.9
390
3 - - 11.3
365
3 - - 0.0
392
3 - - 71.4
375
3 - - 72.0
362
3 - - 0.8
388
3 - - 3.4
389
3 - - 0.0
395
3 - - 3.0
372
3 - - 42.2
416
3 - - 38.0
474
2 - - 17.6
558
2 - - 37.2
559
2 - - 41.2
513
2 - - 40.8
449
2 - - 6.2
448
2 - - 0.0
437
2 - - 0.5
525
2 - - 6.9
540
2 - - 0.0
464
2 - - 40.8
535
2 - - 18.4
450
2 - - 0.0
427
2 - - 31.9
500
2 - - 0.0
423
2 - - 22.5
566
2 - - 39.3
433
2 - - 42.4
494
2 - - 4.6
522
2 - - 2.3
517
2 - - 9.6
481
2 - - 0.0
532
2 - - 37.4
428
2 - - 31.9
429
2 - - 29.1
438
2 - - 3.1
561
2 - - 42.3
439
2 - - 2.5
530
2 - - 8.9
455
2 - - 1.9
486
2 - - 2.0
447
2 - - 10.6
505
AFU_orthologue AFUA_5G13620
2 - - 0.0
520
AFU_orthologue AFUA_2G08440
2 - - 0.0
557
2 - - 20.2
545
2 - - 32.6
553
2 - - 34.9
518
2 - - 10.9
519
2 - - 9.3
443
2 - - 8.9
452
2 - - 0.0
502
2 - - 5.5
542
2 - - 0.0
422
2 - - 0.0
476
2 - - 10.2
515
2 - - 28.8
432
2 - - 39.6
523
2 - - 0.0
533
2 - - 1.9
466
2 - - 39.6
440
2 - - 0.0
425
2 - - 0.0
537
2 - - 38.1
496
2 - - 0.0
550
2 - - 35.6
527
2 - - 13.3
512
2 - - 39.3
564
2 - - 43.5
435
2 - - 0.6
508
2 - - 0.0
459
2 - - 34.3
509
2 - - 36.6
458
2 - - 12.9
548
2 - - 32.3
549
2 - - 39.7
552
2 - - 35.7
510
2 - - 34.9
442
2 - - 0.0
491
2 - - 0.0
503
2 - - 7.6
484
2 - - 5.8
453
2 - - 0.0
543
2 - - 38.7
471
2 - - 36.7
547
2 - - 32.3
430
2 - - 36.4
445
2 - - 0.0
507
2 - - 2.2
457
2 - - 32.1
529
2 - - 6.2
528
2 - - 0.0
461
2 - - 34.2
539
2 - - 0.0
538
2 - - 28.0
421
2 - - 14.8
431
2 - - 36.4
470
2 - - 41.1
504
2 - - 0.0
454
2 - - 0.0
483
2 - - 1.8
460
2 - - 36.1
544
2 - - 23.2
490
2 - - 1.8
556
2 - - 35.0
446
2 - - 0.0
511
2 - - 40.6
487
2 - - 10.0
551
2 - - 34.6
475
2 - - 17.0
492
2 - - 11.6
516
2 - - 31.3
441
2 - - 0.0
524
2 - - 11.7
534
2 - - 13.1
465
2 - - 42.2
426
2 - - 21.8
472
2 - - 12.2
495
AFU_orthologue AFUA_1G07555
2 - - 0.0
563
2 - - 34.4
436
2 - - 3.0
489
2 - - 0.8
488
2 - - 11.3
462
2 - - 38.5
499
2 - - 7.3
498
2 - - 8.7
456
2 - - 20.4
485
2 - - 0.5
506
2 - - 4.0
546
2 - - 31.0
478
2 - - 26.5
560
2 - - 39.0
554
2 - - 40.1
479
2 - - 27.3
444
2 - - 0.0
482
2 - - 4.8
521
2 - - 0.0
468
2 - - 34.8
531
2 - - 0.0
469
2 - - 40.6
473
2 - - 37.5
562
2 - - 41.0
514
2 - - 49.2
526
2 - - 1.4
497
2 - - 2.2
536
2 - - 20.9
480
2 - - 27.9
463
2 - - 37.0
467
2 - - 38.6
424
2 - - 0.0
434
2 - - 36.5
565
2 - - 44.8
493
2 - - 1.5
501
2 - - 0.0
451
2 - - 0.0
477
2 - - 8.8
541
2 - - 0.7
688
1 - - 0.0
832
1 - - 0.0
749
1 - - 0.0
748
1 - - 0.0
689
1 - - 0.0
614
1 - - 0.0
774
1 - - 0.0
876
1 - - 0.0
709
1 - - 0.0
822
1 - - 0.0
817
1 - - 0.0
662
1 - - 0.0
708
1 - - 0.0
626
1 - - 0.0
764
1 - - 0.0
866
1 - - 0.0
727
1 - - 0.0
672
1 - - 0.0
712
1 - - 0.0
750
1 - - 0.0
902
1 - - 0.0
737
1 - - 0.0
636
1 - - 0.0
596
1 - - 0.0
695
1 - - 0.0
835
1 - - 0.0
733
1 - - 0.0
800
1 - - 0.0
896
1 - - 0.0
794
1 - - 0.0
723
1 - - 0.0
665
1 - - 0.0
825
1 - - 0.0
840
1 - - 0.0
576
1 - - 0.0
601
1 - - 0.0
813
1 - - 0.0
715
1 - - 0.0
675
1 - - 0.0
905
1 - - 0.0
641
1 - - 0.0
858
1 - - 0.0
781
1 - - 0.0
859
1 - - 0.0
692
1 - - 0.0
738
1 - - 0.0
891
1 - - 0.0
842
1 - - 0.0
739
1 - - 0.0
728
1 - - 0.0
729
1 - - 0.0
802
1 - - 0.0
818
1 - - 0.0
819
1 - - 0.0
707
1 - - 0.0
690
1 - - 0.0
571
1 - - 0.0
606
1 - - 0.0
687
1 - - 0.0
853
1 - - 0.0
786
1 - - 0.0
884
1 - - 0.0
755
1 - - 0.0
747
1 - - 0.0
646
1 - - 0.0
654
1 - - 0.0
820
1 - - 0.0
660
1 - - 0.0
857
1 - - 0.0
584
1 - - 0.0
683
1 - - 0.0
845
1 - - 0.0
743
1 - - 0.0
830
1 - - 0.0
805
1 - - 0.0
703
1 - - 0.0
871
1 - - 0.0
861
1 - - 0.0
621
1 - - 0.0
670
1 - - 0.0
710
1 - - 0.0
752
1 - - 0.0
591
1 - - 0.0
631
1 - - 0.0
900
1 - - 0.0
651
1 - - 0.0
581
1 - - 0.0
848
1 - - 0.0
849
1 - - 0.0
732
1 - - 0.0
907
1 - - 0.0
808
1 - - 0.0
809
1 - - 0.0
722
1 - - 0.0
677
1 - - 0.0
717
1 - - 0.0
874
1 - - 0.0
616
1 - - 0.0
776
1 - - 0.0
667
1 - - 0.0
850
1 - - 0.0
827
1 - - 0.0
812
1 - - 0.0
864
1 - - 0.0
766
1 - - 0.0
624
1 - - 0.0
594
1 - - 0.0
693
1 - - 0.0
634
1 - - 0.0
837
1 - - 0.0
697
1 - - 0.0
700
1 - - 0.0
894
1 - - 0.0
796
1 - - 0.0
833
1 - - 0.0
910
1 - - 0.0
735
1 - - 0.0
740
1 - - 0.0
725
1 - - 0.0
663
1 - - 0.0
823
1 - - 0.0
680
1 - - 0.0
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