The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Anti-proliferative protein, N-terminal domain
".
FunFam 1: TOB1 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
15 |
P50616 (/IPI)
P50616 (/IPI)
P50616 (/IPI)
P50616 (/IPI)
P50616 (/IPI)
P50616 (/IPI)
P50616 (/IPI)
P50616 (/IPI)
P50616 (/IPI)
P50616 (/IPI)
(5 more) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
11 |
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
(1 more) |
|
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
11 |
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
(1 more) |
|
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
2 | Q61471 (/ISS) Q8R5K6 (/ISS) |
|
Vitamin D receptor binding GO:0042809
Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.
|
2 | Q9JM55 (/IPI) Q9JM55 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q61471 (/IDA) |
|
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
1 | Q61471 (/ISO) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
1 | Q61471 (/IDA) |
There are 27 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
12 |
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
P50616 (/TAS)
(2 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
11 |
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
(1 more) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
11 |
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
(1 more) |
|
Negative regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060212
Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
11 |
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
(1 more) |
|
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
11 |
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
(1 more) |
|
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
|
11 |
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
(1 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | Q61471 (/ISS) Q8R5K6 (/ISS) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q9JM55 (/IMP) Q9JM55 (/IMP) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | Q61471 (/ISS) Q8R5K6 (/ISS) |
|
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
|
2 | Q9JM55 (/IMP) Q9JM55 (/IMP) |
|
Positive regulation of ossification GO:0045778
Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
|
2 | Q9JM55 (/IMP) Q9JM55 (/IMP) |
|
Negative regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060212
Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
2 | Q61471 (/ISS) Q8R5K6 (/ISS) |
|
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
2 | Q61471 (/ISS) Q8R5K6 (/ISS) |
|
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
|
2 | Q61471 (/ISS) Q8R5K6 (/ISS) |
|
Female gamete generation GO:0007292
Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
|
1 | Q14106 (/TAS) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
1 | Q9VXJ9 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q61471 (/ISO) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
1 | Q7SZR1 (/IMP) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
1 | Q61471 (/ISO) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q7SZR1 (/IDA) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q61471 (/IDA) |
|
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
|
1 | Q61471 (/IMP) |
|
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
1 | Q9VXJ9 (/IMP) |
|
Negative regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060212
Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
1 | Q61471 (/ISO) |
|
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
1 | Q61471 (/ISO) |
|
Regulation of SMAD protein signal transduction GO:0060390
Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
|
1 | Q61471 (/IDA) |
|
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
|
1 | Q61471 (/ISO) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
11 |
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
P50616 (/IDA)
(1 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q61471 (/IDA) Q7SZR1 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9JM55 (/ISO) Q9JM55 (/ISO) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
2 | Q61471 (/ISS) Q8R5K6 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q7SZR1 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q14106 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q14106 (/IDA) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
1 | Q61471 (/ISO) |
|
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
|
1 | Q9VXJ9 (/IDA) |
|
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
1 | Q9VXJ9 (/IDA) |
