The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: U2 small nuclear ribonucleoprotein A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
37 P09661 (/IPI) P09661 (/IPI) P09661 (/IPI) P09661 (/IPI) P09661 (/IPI) P09661 (/IPI) P09661 (/IPI) P09661 (/IPI) P09661 (/IPI) P09661 (/IPI)
(27 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
36 P09661 (/HDA) P09661 (/HDA) P09661 (/HDA) P09661 (/HDA) P09661 (/HDA) P09661 (/HDA) P09661 (/HDA) P09661 (/HDA) P09661 (/HDA) P09661 (/HDA)
(26 more)
U2 snRNA binding GO:0030620
Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA).
1 Q9BLB6 (/IDA)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
38 P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(28 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
38 P57784 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS)
(28 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
37 P09661 (/IC) P09661 (/IC) P09661 (/IC) P09661 (/IC) P09661 (/IC) P09661 (/IC) P09661 (/IC) P09661 (/IC) P09661 (/IC) P09661 (/IC)
(27 more)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
37 P09661 (/IGI) P09661 (/IGI) P09661 (/IGI) P09661 (/IGI) P09661 (/IGI) P09661 (/IGI) P09661 (/IGI) P09661 (/IGI) P09661 (/IGI) P09661 (/IGI)
(27 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
36 P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS)
(26 more)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
36 P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS)
(26 more)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
36 P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS)
(26 more)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q9V4Q8 (/HMP)
MRNA 3'-splice site recognition GO:0000389
Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.
1 Q9BLB6 (/IMP)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
1 P57784 (/ISO)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 Q9V4Q8 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q9V4Q8 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P57784 (/ISO)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 P43333 (/IEP)
Feminization of hermaphroditic germ-line GO:0040022
The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite.
1 Q9BLB6 (/IMP)
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
1 Q9USX8 (/ISS)
Germline cell cycle switching, mitotic to meiotic cell cycle GO:0051729
The process in which a germline cell switches cell cycle mode from mitotic to meiotic division.
1 Q9BLB6 (/IGI)

There are 34 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
43 H0YKK0 (/IDA) H0YKK0 (/IDA) H0YKK0 (/IDA) H0YKK0 (/IDA) H0YKK0 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(33 more)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
41 H0YKK0 (/IDA) H0YKK0 (/IDA) H0YKK0 (/IDA) H0YKK0 (/IDA) H0YKK0 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(31 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
38 P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(28 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
37 P57784 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS)
(27 more)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
37 P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(27 more)
U2-type catalytic step 2 spliceosome GO:0071007
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
37 P57784 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS) Q4R8Y8 (/ISS)
(27 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
36 P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS)
(26 more)
U2 snRNP GO:0005686
A ribonucleoprotein complex that contains small nuclear RNA U2.
36 P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS)
(26 more)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
36 P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(26 more)
Small nuclear ribonucleoprotein complex GO:0030532
A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs.
36 P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS) P09661 (/TAS)
(26 more)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
36 P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(26 more)
U2-type catalytic step 2 spliceosome GO:0071007
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
36 P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(26 more)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
36 P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA) P09661 (/IDA)
(26 more)
U2 snRNP GO:0005686
A ribonucleoprotein complex that contains small nuclear RNA U2.
2 Q9BLB6 (/IDA) Q9USX8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9USX8 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P57784 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P57784 (/ISO)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
1 P57784 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P43333 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P43333 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9USX8 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P43333 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 P43333 (/IDA)
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
1 P43333 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 P57784 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 P57784 (/ISO)
Small nuclear ribonucleoprotein complex GO:0030532
A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs.
1 Q9V4Q8 (/ISS)
U2-type prespliceosome GO:0071004
A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
1 Q9USX8 (/ISO)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
1 P57784 (/ISO)
U2-type catalytic step 2 spliceosome GO:0071007
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
1 P57784 (/ISO)
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
1 Q9V4Q8 (/HDA)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
1 Q9V4Q8 (/HDA)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
1 P57784 (/ISO)
Post-mRNA release spliceosomal complex GO:0071014
A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.
1 Q9USX8 (/IDA)
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