The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"L-arginine/glycine Amidinotransferase; Chain A
".
FunFam 4: N(G),N(G)-dimethylarginine dimethylaminohydrolase ...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Dimethylargininase activity GO:0016403
Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.
|
19 |
O08557 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
(9 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
18 |
O95865 (/IPI)
O95865 (/IPI)
O95865 (/IPI)
O95865 (/IPI)
O95865 (/IPI)
O95865 (/IPI)
O95865 (/IPI)
O95865 (/IPI)
O95865 (/IPI)
V9HW53 (/IPI)
(8 more) |
|
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
16 |
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
(6 more) |
|
Dimethylargininase activity GO:0016403
Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.
|
6 | O08557 (/ISS) P56965 (/ISS) Q3SX44 (/ISS) Q6MG60 (/ISS) Q99LD8 (/ISS) Q9CWS0 (/ISS) |
|
Dimethylargininase activity GO:0016403
Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.
|
2 | Q99LD8 (/ISO) Q9CWS0 (/ISO) |
|
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
|
2 | O08557 (/IDA) Q6MG60 (/IDA) |
|
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
|
2 | Q99LD8 (/ISO) Q9CWS0 (/ISO) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P56965 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q9CWS0 (/ISO) |
|
Dimethylargininase activity GO:0016403
Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.
|
1 | Q9CWS0 (/IMP) |
|
Dimethylargininase activity GO:0016403
Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.
|
1 | O08557 (/TAS) |
|
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0016813
Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2.
|
1 | Q5LLG3 (/ISS) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Citrulline metabolic process GO:0000052
The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
|
16 |
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O94760 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
(6 more) |
|
Arginine catabolic process GO:0006527
The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
|
16 |
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
(6 more) |
|
Nitric oxide mediated signal transduction GO:0007263
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
|
16 |
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
(6 more) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
16 |
O94760 (/ISS)
O94760 (/ISS)
O94760 (/ISS)
O94760 (/ISS)
O94760 (/ISS)
O94760 (/ISS)
O94760 (/ISS)
O95865 (/ISS)
O95865 (/ISS)
O95865 (/ISS)
(6 more) |
|
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
|
16 |
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
(6 more) |
|
Nitric oxide biosynthetic process GO:0006809
The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
|
9 | O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
9 | O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) O95865 (/TAS) |
|
Regulation of systemic arterial blood pressure GO:0003073
The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
|
7 | O94760 (/ISS) O94760 (/ISS) O94760 (/ISS) O94760 (/ISS) O94760 (/ISS) O94760 (/ISS) O94760 (/ISS) |
|
Arginine catabolic process GO:0006527
The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
|
7 | O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
7 | O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) |
|
Negative regulation of vascular permeability GO:0043116
Any process that reduces the extent to which blood vessels can be pervaded by fluid.
|
7 | O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) |
|
Negative regulation of cellular response to hypoxia GO:1900038
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia.
|
7 | O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) O94760 (/IDA) |
|
Citrulline metabolic process GO:0000052
The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
|
6 | O08557 (/ISS) P56965 (/ISS) Q3SX44 (/ISS) Q6MG60 (/ISS) Q99LD8 (/ISS) Q9CWS0 (/ISS) |
|
Citrulline metabolic process GO:0000052
The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
|
2 | Q99LD8 (/ISO) Q9CWS0 (/ISO) |
|
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
|
2 | O08557 (/IDA) Q6MG60 (/IDA) |
|
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
|
2 | Q99LD8 (/ISO) Q9CWS0 (/ISO) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
2 | P56965 (/IDA) Q3SX44 (/IDA) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
2 | O08557 (/IMP) Q9CWS0 (/IMP) |
|
Regulation of systemic arterial blood pressure GO:0003073
The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
|
1 | Q9CWS0 (/IMP) |
|
Arginine catabolic process GO:0006527
The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
|
1 | Q99LD8 (/ISA) |
|
Arginine catabolic process GO:0006527
The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
|
1 | Q9CWS0 (/ISO) |
|
Nitric oxide biosynthetic process GO:0006809
The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
|
1 | P56965 (/IDA) |
|
Nitric oxide biosynthetic process GO:0006809
The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
|
1 | Q9CWS0 (/ISO) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q9CWS0 (/ISO) |
|
Protein nitrosylation GO:0017014
The covalent addition of a nitric oxide group to an amino acid within a protein.
|
1 | P56965 (/IDA) |
|
Protein nitrosylation GO:0017014
The covalent addition of a nitric oxide group to an amino acid within a protein.
|
1 | Q9CWS0 (/ISO) |
|
Negative regulation of vascular permeability GO:0043116
Any process that reduces the extent to which blood vessels can be pervaded by fluid.
|
1 | Q9CWS0 (/ISO) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
1 | Q9CWS0 (/ISO) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | O08557 (/IMP) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | Q9CWS0 (/ISO) |
|
Negative regulation of cellular response to hypoxia GO:1900038
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia.
|
1 | Q9CWS0 (/ISO) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
|
22 |
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
Q5SRR8 (/IDA)
(12 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
22 |
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
O95865 (/IDA)
Q5SRR8 (/IDA)
(12 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
16 |
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O94760 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
O95865 (/TAS)
(6 more) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
16 |
O94760 (/HDA)
O94760 (/HDA)
O94760 (/HDA)
O94760 (/HDA)
O94760 (/HDA)
O94760 (/HDA)
O94760 (/HDA)
O95865 (/HDA)
O95865 (/HDA)
O95865 (/HDA)
(6 more) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9CWS0 (/HDA) |
|
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
|
1 | Q99LD8 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q99LD8 (/ISO) |
