The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"L-arginine/glycine Amidinotransferase; Chain A
".
FunFam 1: Eukaryotic translation initiation factor 6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
25 |
P56537 (/IPI)
P56537 (/IPI)
P56537 (/IPI)
P56537 (/IPI)
P56537 (/IPI)
P56537 (/IPI)
P56537 (/IPI)
P56537 (/IPI)
P56537 (/IPI)
P56537 (/IPI)
(15 more) |
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
|
15 |
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
(5 more) |
Ribosomal large subunit binding GO:0043023
Interacting selectively and non-covalently with any part of the larger ribosomal subunit.
|
10 | Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) |
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
|
2 | O55135 (/ISO) O55135 (/ISO) |
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
|
2 | O55135 (/ISS) O55135 (/ISS) |
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
1 | P56538 (/ISS) |
Ribosomal large subunit binding GO:0043023
Interacting selectively and non-covalently with any part of the larger ribosomal subunit.
|
1 | O94476 (/ISO) |
Ribosomal large subunit binding GO:0043023
Interacting selectively and non-covalently with any part of the larger ribosomal subunit.
|
1 | Q551M2 (/ISS) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
|
19 |
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
(9 more) |
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
19 |
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
(9 more) |
Regulation of fatty acid biosynthetic process GO:0042304
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.
|
19 |
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
(9 more) |
Regulation of megakaryocyte differentiation GO:0045652
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
|
19 |
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
(9 more) |
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
19 |
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
(9 more) |
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
|
19 |
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
P56537 (/ISS)
(9 more) |
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
|
16 |
O62106 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
(6 more) |
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
|
15 |
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
(5 more) |
Mature ribosome assembly GO:0042256
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.
|
15 |
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
P56537 (/IMP)
(5 more) |
Ribosomal subunit export from nucleus GO:0000054
The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
|
10 | Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) |
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000463
Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
|
10 | Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) |
Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000466
Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
|
10 | Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) |
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
|
10 | Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) Q12522 (/IGI) |
Ribosomal large subunit biogenesis GO:0042273
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
|
10 | Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) |
Assembly of large subunit precursor of preribosome GO:1902626
The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome.
|
10 | Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) Q12522 (/IMP) |
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
|
6 | O55135 (/ISS) O55135 (/ISS) Q3KRD8 (/ISS) Q9TU47 (/ISS) Q9TU47 (/ISS) Q9TU47 (/ISS) |
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
|
6 | O55135 (/ISS) O55135 (/ISS) Q3KRD8 (/ISS) Q9TU47 (/ISS) Q9TU47 (/ISS) Q9TU47 (/ISS) |
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
|
2 | O55135 (/IMP) O55135 (/IMP) |
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
|
2 | Q9M060 (/IMP) Q9M060 (/IMP) |
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
2 | O55135 (/IMP) O55135 (/IMP) |
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
|
2 | O55135 (/ISO) O55135 (/ISO) |
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
|
2 | O55135 (/ISO) O55135 (/ISO) |
Mature ribosome assembly GO:0042256
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.
|
2 | O55135 (/ISO) O55135 (/ISO) |
Mature ribosome assembly GO:0042256
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.
|
2 | O55135 (/ISS) O55135 (/ISS) |
Regulation of fatty acid biosynthetic process GO:0042304
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.
|
2 | O55135 (/IMP) O55135 (/IMP) |
Regulation of megakaryocyte differentiation GO:0045652
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
|
2 | O55135 (/IMP) O55135 (/IMP) |
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
2 | O55135 (/IMP) O55135 (/IMP) |
Cellular response to abscisic acid stimulus GO:0071215
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
|
2 | Q9M060 (/IEP) Q9M060 (/IEP) |
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
|
2 | O55135 (/IMP) O55135 (/IMP) |
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
1 | P56538 (/ISS) |
Ribosomal large subunit biogenesis GO:0042273
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
|
1 | O94476 (/ISO) |
Ribosomal large subunit biogenesis GO:0042273
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
|
1 | Q551M2 (/ISS) |
There are 18 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
32 |
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
(22 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
26 |
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
(16 more) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
17 |
Q12522 (/IDA)
Q12522 (/IDA)
Q12522 (/IDA)
Q12522 (/IDA)
Q12522 (/IDA)
Q12522 (/IDA)
Q12522 (/IDA)
Q12522 (/IDA)
Q12522 (/IDA)
Q12522 (/IDA)
(7 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
15 |
P56537 (/TAS)
P56537 (/TAS)
P56537 (/TAS)
P56537 (/TAS)
P56537 (/TAS)
P56537 (/TAS)
P56537 (/TAS)
P56537 (/TAS)
P56537 (/TAS)
P56537 (/TAS)
(5 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
15 |
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
P56537 (/IDA)
(5 more) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
15 |
P56537 (/HDA)
P56537 (/HDA)
P56537 (/HDA)
P56537 (/HDA)
P56537 (/HDA)
P56537 (/HDA)
P56537 (/HDA)
P56537 (/HDA)
P56537 (/HDA)
P56537 (/HDA)
(5 more) |
Preribosome, large subunit precursor GO:0030687
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
|
10 | Q12522 (/HDA) Q12522 (/HDA) Q12522 (/HDA) Q12522 (/HDA) Q12522 (/HDA) Q12522 (/HDA) Q12522 (/HDA) Q12522 (/HDA) Q12522 (/HDA) Q12522 (/HDA) |
Preribosome, large subunit precursor GO:0030687
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
|
10 | Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) Q12522 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O55135 (/ISO) O55135 (/ISO) |
Lamin filament GO:0005638
Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.
|
2 | O55135 (/IDA) O55135 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | O55135 (/ISO) O55135 (/ISO) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
2 | Q4Q1Y7 (/ISO) Q4Q1Y7 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O55135 (/ISO) O55135 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9M060 (/IDA) Q9M060 (/IDA) |
Intermediate filament GO:0005882
A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
|
2 | O55135 (/IDA) O55135 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O94476 (/HDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O94476 (/HDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P56538 (/ISS) |