The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Putative signal peptide peptidase-like 2B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aspartic endopeptidase activity, intramembrane cleaving GO:0042500
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8TCT7 (/IPI)
Aspartic endopeptidase activity, intramembrane cleaving GO:0042500
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.
1 Q8TCT7 (/IDA)
Aspartic endopeptidase activity, intramembrane cleaving GO:0042500
Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.
1 Q8TCT7 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8TCT7 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q3TD49 (/ISO)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Membrane protein intracellular domain proteolysis GO:0031293
The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Negative regulation of coagulation GO:0050819
Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.
3 F1QYI0 (/IMP) Q5BP99 (/IMP) Q803E8 (/IMP)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
2 Q3TD49 (/ISS) Q5PQL3 (/ISS)
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
1 Q8TCT7 (/IDA)
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
1 Q3TD49 (/ISO)
Regulation of tumor necrosis factor-mediated signaling pathway GO:0010803
Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
1 Q8TCT7 (/TAS)
Membrane protein intracellular domain proteolysis GO:0031293
The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.
1 Q8TCT7 (/IDA)
Membrane protein intracellular domain proteolysis GO:0031293
The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.
1 Q8TCT7 (/IMP)
Membrane protein intracellular domain proteolysis GO:0031293
The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.
1 Q3TD49 (/ISO)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
1 Q8TCT7 (/IDA)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
1 Q3TD49 (/ISO)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
1 Q8TCT7 (/IMP)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
1 Q3TD49 (/ISO)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of cytoplasmic side of endoplasmic reticulum membrane GO:0071458
The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane.
4 Q3TD49 (/ISS) Q5BP99 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Integral component of lumenal side of endoplasmic reticulum membrane GO:0071556
The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.
4 Q3TD49 (/ISS) Q5BP99 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Golgi-associated vesicle membrane GO:0030660
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
3 Q3TD49 (/ISS) Q5F383 (/ISS) Q5PQL3 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 A0A087WZ50 (/IDA) Q8TCT7 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 A0A087WZ50 (/IDA) Q8TCT7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 A0A087WZ50 (/IDA) Q8TCT7 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
2 A0A087WZ50 (/IDA) Q8TCT7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q3TD49 (/ISS) Q5PQL3 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q3TD49 (/ISO)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
1 Q8TCT7 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
1 Q3TD49 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q5BP99 (/ISS)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q3TD49 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q3TD49 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8TCT7 (/TAS)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 Q8TCT7 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 Q3TD49 (/ISO)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q3TD49 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8TCT7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q3TD49 (/ISO)
Golgi-associated vesicle membrane GO:0030660
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
1 Q8TCT7 (/IDA)
Golgi-associated vesicle membrane GO:0030660
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
1 Q3TD49 (/ISO)
Integral component of cytoplasmic side of endoplasmic reticulum membrane GO:0071458
The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane.
1 Q8TCT7 (/IDA)
Integral component of cytoplasmic side of endoplasmic reticulum membrane GO:0071458
The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane.
1 Q3TD49 (/ISO)
Integral component of lumenal side of endoplasmic reticulum membrane GO:0071556
The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.
1 Q8TCT7 (/IDA)
Integral component of lumenal side of endoplasmic reticulum membrane GO:0071556
The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane.
1 Q3TD49 (/ISO)
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