The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Mannitol-specific EII; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Anion exchange protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Anion:anion antiporter activity GO:0015301
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
7 P04919 (/ISS) P04919 (/ISS) P23562 (/ISS) Q2Z1P8 (/ISS) Q2Z1P9 (/ISS) Q5RBP3 (/ISS) Q9TUQ0 (/ISS)
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
6 P02730 (/ISS) P23562 (/ISS) Q2Z1P8 (/ISS) Q2Z1P9 (/ISS) Q5RBP3 (/ISS) Q9TUQ0 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 F1RQY6 (/IPI) P02730 (/IPI) P04919 (/IPI) P04919 (/IPI)
Inorganic anion exchanger activity GO:0005452
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out).
3 P04919 (/ISS) P04919 (/ISS) P23562 (/ISS)
Bicarbonate transmembrane transporter activity GO:0015106
Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
3 P02730 (/IDA) P04919 (/IDA) P04919 (/IDA)
Bicarbonate transmembrane transporter activity GO:0015106
Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
3 P04919 (/ISS) P04919 (/ISS) P23562 (/ISS)
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
3 P02730 (/IPI) P04919 (/IPI) P04919 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 P04919 (/ISO) P04919 (/ISO)
Inorganic anion exchanger activity GO:0005452
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out).
2 P04919 (/ISO) P04919 (/ISO)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
2 P04919 (/ISO) P04919 (/ISO)
Bicarbonate transmembrane transporter activity GO:0015106
Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
2 P04919 (/ISO) P04919 (/ISO)
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
2 P04919 (/IDA) P04919 (/IDA)
Anion:anion antiporter activity GO:0015301
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
2 P04919 (/IMP) P04919 (/IMP)
Anion:anion antiporter activity GO:0015301
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
2 P04919 (/ISO) P04919 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 P04919 (/ISO) P04919 (/ISO)
Hemoglobin binding GO:0030492
Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
2 P04919 (/IDA) P04919 (/IDA)
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
2 P04919 (/ISO) P04919 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P04919 (/ISO) P04919 (/ISO)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 P23562 (/IPI)
Inorganic anion exchanger activity GO:0005452
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out).
1 P02730 (/IDA)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P23562 (/IPI)
Anion transmembrane transporter activity GO:0008509
Enables the transfer of a negatively charged ion from one side of a membrane to the other.
1 P02730 (/TAS)
Anion:anion antiporter activity GO:0015301
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
1 P02730 (/IDA)
Anion:anion antiporter activity GO:0015301
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
1 P02730 (/TAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P23562 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P02730 (/IPI)
Protein membrane anchor GO:0043495
Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific membrane location.
1 P02730 (/TAS)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 P02730 (/ISS) P23562 (/ISS) Q2Z1P8 (/ISS) Q2Z1P9 (/ISS) Q5RBP3 (/ISS) Q9TUQ0 (/ISS)
Anion transport GO:0006820
The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 P23562 (/ISS) Q2Z1P8 (/ISS) Q2Z1P9 (/ISS) Q5RBP3 (/ISS) Q9TUQ0 (/ISS)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P02730 (/IDA) P04919 (/IDA) P04919 (/IDA)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P04919 (/ISS) P04919 (/ISS) P23562 (/ISS)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
2 P04919 (/IDA) P04919 (/IDA)
Anion transport GO:0006820
The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P04919 (/ISO) P04919 (/ISO)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P04919 (/IDA) P04919 (/IDA)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
2 P04919 (/IMP) P04919 (/IMP)
Response to carbon dioxide GO:0010037
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.
2 P04919 (/ISO) P04919 (/ISO)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
2 P04919 (/ISO) P04919 (/ISO)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P04919 (/ISO) P04919 (/ISO)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P02730 (/TAS) P23562 (/TAS)
Plasma membrane phospholipid scrambling GO:0017121
The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
2 P04919 (/IMP) P04919 (/IMP)
Negative regulation of urine volume GO:0035811
Any process that decreases the amount of urine excreted from the body over a unit of time.
2 P04919 (/IMP) P04919 (/IMP)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
2 P04919 (/ISO) P04919 (/ISO)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 P04919 (/ISO) P04919 (/ISO)
PH elevation GO:0045852
Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.
2 P04919 (/IMP) P04919 (/IMP)
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
2 P04919 (/ISO) P04919 (/ISO)
Erythrocyte development GO:0048821
The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
2 P04919 (/IMP) P04919 (/IMP)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 P04919 (/ISO) P04919 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
2 P04919 (/IMP) P04919 (/IMP)
Anion transport GO:0006820
The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P02730 (/IDA)
Anion transport GO:0006820
The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P02730 (/TAS)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P23562 (/TAS)
Cellular ion homeostasis GO:0006873
Any process involved in the maintenance of an internal steady state of ions at the level of a cell.
1 P02730 (/TAS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 P23562 (/IEP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
1 P23562 (/IEP)
Response to carbon dioxide GO:0010037
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.
1 P23562 (/IDA)
Response to alkaline pH GO:0010446
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.
1 P23562 (/IEP)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
1 P23562 (/IEP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
1 P23562 (/IDA)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P23562 (/IEP)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 P23562 (/IDA)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P23562 (/IDA)
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
1 P23562 (/IDA)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P23562 (/IDA)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
7 P04919 (/ISS) P04919 (/ISS) P23562 (/ISS) Q2Z1P8 (/ISS) Q2Z1P9 (/ISS) Q5RBP3 (/ISS) Q9TUQ0 (/ISS)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
7 P02730 (/ISS) P04919 (/ISS) P04919 (/ISS) Q2Z1P8 (/ISS) Q2Z1P9 (/ISS) Q5RBP3 (/ISS) Q9TUQ0 (/ISS)
Cortical cytoskeleton GO:0030863
The portion of the cytoskeleton that lies just beneath the plasma membrane.
5 P23562 (/ISS) Q2Z1P8 (/ISS) Q2Z1P9 (/ISS) Q5RBP3 (/ISS) Q9TUQ0 (/ISS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
4 P02730 (/IDA) P04919 (/IDA) P04919 (/IDA) P23562 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
4 Q2Z1P8 (/ISS) Q2Z1P9 (/ISS) Q5RBP3 (/ISS) Q9TUQ0 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P04919 (/IDA) P04919 (/IDA) P23562 (/IDA)
Cortical cytoskeleton GO:0030863
The portion of the cytoskeleton that lies just beneath the plasma membrane.
3 P02730 (/IDA) P04919 (/IDA) P04919 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P04919 (/ISO) P04919 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P04919 (/ISO) P04919 (/ISO)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 P04919 (/IDA) P04919 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P04919 (/ISO) P04919 (/ISO)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
2 P04919 (/ISO) P04919 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P04919 (/IDA) P04919 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P04919 (/ISO) P04919 (/ISO)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
2 P04919 (/ISO) P04919 (/ISO)
Cortical cytoskeleton GO:0030863
The portion of the cytoskeleton that lies just beneath the plasma membrane.
2 P04919 (/ISO) P04919 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P02730 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P02730 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P02730 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P23562 (/IDA)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
1 P23562 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P02730 (/NAS)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 P23562 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P02730 (/HDA)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
1 P02730 (/HDA)
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