The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Kinesin motor domain
".
FunFam 73: Kinesin-like protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
ATP-dependent microtubule motor activity, plus-end-directed GO:0008574
Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP.
|
7 | C8V3Q8 (/IMP) C8V3Q8 (/IMP) P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | P28743 (/IPI) P28743 (/IPI) P28743 (/IPI) P28743 (/IPI) P28743 (/IPI) |
ATP-dependent microtubule motor activity, plus-end-directed GO:0008574
Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP.
|
5 | P28743 (/IGI) P28743 (/IGI) P28743 (/IGI) P28743 (/IGI) P28743 (/IGI) |
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
2 | C8V3Q8 (/IDA) C8V3Q8 (/IDA) |
Microtubule plus-end binding GO:0051010
Interacting selectively and non-covalently with the plus end of a microtubule.
|
2 | C8V3Q8 (/IDA) C8V3Q8 (/IDA) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
|
5 | P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) |
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
|
5 | P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) |
Nuclear migration along microtubule GO:0030473
The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.
|
5 | P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) P28743 (/IMP) |
Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
|
5 | P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) |
Cortical microtubule organization GO:0043622
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
|
2 | C8V3Q8 (/IMP) C8V3Q8 (/IMP) |
Apical protein localization GO:0045176
Any process in which a protein is transported to, or maintained in, apical regions of the cell.
|
2 | C8V3Q8 (/IMP) C8V3Q8 (/IMP) |
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
2 | C8V3Q8 (/IMP) C8V3Q8 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
|
7 | C8V3Q8 (/IDA) C8V3Q8 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
5 | P28743 (/HDA) P28743 (/HDA) P28743 (/HDA) P28743 (/HDA) P28743 (/HDA) |
Kinesin complex GO:0005871
Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
|
5 | P28743 (/TAS) P28743 (/TAS) P28743 (/TAS) P28743 (/TAS) P28743 (/TAS) |
Cortical microtubule plus-end GO:1903754
The plus-end of a cortical microtubule.
|
5 | P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) P28743 (/IDA) |
Spindle pole body GO:0005816
The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.
|
2 | C8V3Q8 (/IDA) C8V3Q8 (/IDA) |
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
|
2 | C8V3Q8 (/IMP) C8V3Q8 (/IMP) |
Spindle midzone GO:0051233
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
|
2 | C8V3Q8 (/IDA) C8V3Q8 (/IDA) |