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CATH Superfamily 3.40.630.30

Gcn5-related N-acetyltransferase (GNAT)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 200: N-alpha-acetyltransferase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-terminal amino-acid N(alpha)-acetyltransferase NatA. [EC: 2.3.1.255]
(1) Acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-N(alpha)- acetyl-glycyl-[protein] + CoA. (2) Acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal- N(alpha)-acetyl-L-alanyl-[protein] + CoA. (3) Acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal- N(alpha)-acetyl-L-seryl-[protein] + CoA. (4) Acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal- N(alpha)-acetyl-L-valyl-[protein] + CoA. (5) Acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal- N(alpha)-acetyl-L-cysteinyl-[protein] + CoA. (6) Acetyl-CoA + an N-terminal-L-threonyl-[protein] = an N-terminal- N(alpha)-acetyl-L-threonyl-[protein] + CoA.
  • N-terminal-acetylases (NATs) catalyze the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.
  • This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic.
  • The NatA complex is found in all eukaryotic organisms, and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val residues, that became available after removal of the initiator methionine.
  • Formerly EC 2.3.1.88.
 18 A0A0U3H2L6 A0A0U3H2L6 A0A0U3H2L6 A0A0U3H2L6 M1IT69 M1IT69 M1IT69 M1IT69 M1JAD5 M1JAD5
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