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CATH Superfamily 3.40.605.10

Aldehyde Dehydrogenase; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Succinate-semialdehyde dehydrogenase IAldehyde-alcohol dehydrogenaseCytosolic 10-formyltetrahydrofolate dehydrogenasealpha-aminoadipic semialdehyde dehydrogenase4-trimethylaminobutyraldehyde dehydrogenase isoform X1Aldehyde dehydrogenaseAldehyde dehydrogenase ANADP-dependent glyceraldehyde-3-phosphate dehydrogenaseAldehyde dehydrogenaseNAD-dependent succinate-semialdehyde dehydrogenaseSuccinate-semialdehyde dehydrogenase, mitochondrialSC:21-pyrroline-5-carboxylate dehydrogenase1-pyrroline-5-carboxylate dehydrogenase 1Aldehyde dehydrogenase, mitochondrialAldehyde dehydrogenase family 1 member A3Aldehyde dehydrogenase 1Gamma-glutamyl phosphate reductaseMethylmalonate-semialdehyde dehydrogenase [acylating]Aldehyde dehydrogenaseNAD/NADP-dependent betaine aldehyde dehydrogenaseN-succinylglutamate 5-semialdehyde dehydrogenaseALD5p Mitochondrial aldehyde dehydrogenaseNAD-dependent succinate-semialdehyde dehydrogenaseNADP-dependent glyceraldehyde-3-phosphate dehydrogenasealdehyde dehydrogenase 22A1Bifunctional protein PutAEthanolamine utilization aldehyde dehydrogenaseprobable aldehyde dehydrogenaseNADP-dependent glyceraldehyde-3-phosphate dehydrogenaseSuccinate-semialdehyde dehydrogenase (Eurofung)Aldehyde dehydrogenaseAldehyde dehydrogenase, putativeAldehyde dehydrogenase, dimeric NADP-preferringNAD-dependent succinate-semialdehyde dehydrogenaseAldehyde dehydrogenase, mitochondrialPhenylacetic acid degradation protein PaaNAldehyde dehydrogenase family 16 member A1Aldehyde dehydrogenase family proteinSuccinate-semialdehyde dehydrogenasePhenylacetic acid degradation protein MaoCNADP-dependent fatty aldehyde dehydrogenaseAldehyde dehydrogenase 1 family member L1Succinate-semialdehyde dehydrogenaseAlpha-aminoadipic semialdehyde dehydrogenaseAldehyde dehydrogenase 1 family member A3Succinate semialdehyde dehydrogenaseSuccinate-semialdehyde dehydrogenase [NADP+]Aldehyde dehydrogenase 16 family member A1Aldehyde dehydrogenase family 7 member A1Aldehyde dehydrogenase, putativeProbable aldehyde dehydrogenaseCRE-ALH-9 proteinCarnitine dehydrataseAldehyde dehydrogenaseAldehyde dehydrogenaseDelta-1-pyrroline-5-carboxylate synthaseAldehyde dehydrogenaseSuccinate-semialdehyde dehydrogenase mitochondrialAldehyde dehydrogenase 3 family, member A2aSuccinate-semialdehyde dehydrogenaseGeranial dehydrogenase GeoBAldehyde dehydrogenaseDelta-1-pyrroline-5-carboxylate synthaseSuccinate-semialdehyde dehydrogenase, mitochondrialUncharacterized proteinUncharacterized proteinAlh-11Delta-1-pyrroline-5-carboxylate synthaseDelta-1-pyrroline-5-carboxylate synthasePredicted proteinAldehyde dehydrogenase2-aminomuconic acid semialdehyde dehydrogenaseUncharacterized proteinUncharacterized proteinMalonic semialdehyde oxidative decarboxylaseUncharacterized protein4-hydroxybenzaldehyde dehydrogenase (NADP(+))Probable aldehyde dehydrogenaseL-glutamate gamma-semialdehyde dehydrogenasePredicted proteinCoA-acylating methylmalonate-semialdehyde dehydrogenaseGamma-glutamyl phosphate reductase 2Succinate-semialdehyde dehydrogenase, mitochondrialUncharacterized proteinUncharacterized proteinUncharacterized proteinSuccinate semialdehyde dehydrogenaseOs07g0689150 proteinAldehyde dehydrogenase X, mitochondrialOs12g0177900 proteinAldehyde dehydrogenaseUncharacterized proteinAldehyde dehydrogenase 4 family member A1Uncharacterized proteinPredicted proteinAldehyde dehydrogenase, putativeUncharacterized proteinUncharacterized proteinUncharacterized proteinAldehyde dehydrogenase family proteinUncharacterized proteinUncharacterized proteinPredicted proteinALdehyde deHydrogenaseUncharacterized protein10-formyltetrahydrofolate dehydrogenaseUncharacterized protein10-formyltetrahydrofolate dehydrogenase10-formyltetrahydrofolate dehydrogenaseUncharacterized proteinUncharacterized proteinUncharacterized proteinDelta-1-pyrroline-5-carboxylate synthaseTranscription regulator10-formyltetrahydrofolate dehydrogenaseUncharacterized proteinUncharacterized proteinSuccinate semialdehyde dehydrogenase, putativePutative aldehyde dehydrogenaseUncharacterized proteinPredicted proteinUncharacterized proteinPredicted proteinGamma-glutamyl phosphate reductase-like proteinLong-chain acyl-protein thioester reductaseAldehyde dehydrogenase, putativeAldehyde dehydrogenase 3 family member B1Aldehyde dehydrogenase, putativeUncharacterized proteinDelta-1-pyrroline-5-carboxylate synthase BUncharacterized proteinUncharacterized proteinAldehyde dehydrogenase, putativePredicted proteinALdehyde deHydrogenase4-trimethylaminobutyraldehyde dehydrogenaseUncharacterized proteinUncharacterized proteinAldehyde dehydrogenase 4 family member A1Aldehyde dehydrogenase 4 family member A1Uncharacterized proteinUncharacterized proteinUncharacterized proteinAldehyde dehydrogenaseAldehyde dehydrogenase, putative
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FunFam 12: NAD-dependent succinate-semialdehyde dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Succinate-semialdehyde dehydrogenase [NAD(P)+] activity GO:0009013
Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+.
 27 P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA)
(17 more)
Succinate-semialdehyde dehydrogenase (NAD+) activity GO:0004777
Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.
 18 P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA)
(8 more)
Vanillin dehydrogenase activity GO:0050608
Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate.
 2 G2IMC6 (/IMP) G2IMC6 (/IMP)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
 1 Q8GAK7 (/IDA)
Vanillin dehydrogenase activity GO:0050608
Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate.
 1 O05619 (/IDA)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
 1 Q8GAK7 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
 1 Q8GAK7 (/IDA)
Showing 1 to 7 of 7 entries

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Arginine catabolic process GO:0006527
The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
 18 P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP)
(8 more)
Nitrogen compound metabolic process GO:0006807
The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
 18 P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA) P76149 (/IDA)
(8 more)
Putrescine catabolic process GO:0009447
The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.
 18 P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP)
(8 more)
Putrescine catabolic process GO:0009447
The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.
 18 P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP)
(8 more)
Gamma-aminobutyric acid catabolic process GO:0009450
The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
 18 P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP) P76149 (/IEP)
(8 more)
Gamma-aminobutyric acid catabolic process GO:0009450
The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
 18 P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP) P76149 (/IMP)
(8 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
 9 P9WNX9 (/IDA) P9WNX9 (/IDA) P9WNX9 (/IDA) P9WNX9 (/IDA) P9WNX9 (/IDA) P9WNX9 (/IDA) P9WNX9 (/IDA) P9WNX9 (/IDA) P9WNX9 (/IDA)
D-xylose catabolic process GO:0042843
The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.
 1 Q8GAK7 (/TAS)
Showing 1 to 8 of 8 entries

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 9 P9WNX9 (/HDA) P9WNX9 (/HDA) P9WNX9 (/HDA) P9WNX9 (/HDA) P9WNX9 (/HDA) P9WNX9 (/HDA) P9WNX9 (/HDA) P9WNX9 (/HDA) P9WNX9 (/HDA)
Showing 1 to 1 of 1 entries
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