The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Pyruvate dehydrogenase E1 component

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
138 P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA)
(128 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
138 P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI)
(128 more)
Pyruvate dehydrogenase activity GO:0004738
Catalysis of the oxidative decarboxylation of pyruvate.
132 P0AFG8 (/IGI) P0AFG8 (/IGI) P0AFG8 (/IGI) P0AFG8 (/IGI) P0AFG8 (/IGI) P0AFG8 (/IGI) P0AFG8 (/IGI) P0AFG8 (/IGI) P0AFG8 (/IGI) P0AFG8 (/IGI)
(122 more)
Thiamine pyrophosphate binding GO:0030976
Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
132 P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA)
(122 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
132 P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI) P0AFG8 (/IPI)
(122 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
132 P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA) P0AFG8 (/IDA)
(122 more)
Pyruvate dehydrogenase (acetyl-transferring) activity GO:0004739
Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
6 P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA)
Pyruvate dehydrogenase activity GO:0004738
Catalysis of the oxidative decarboxylation of pyruvate.
5 Q47US5 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS)
Pyruvate dehydrogenase (acetyl-transferring) activity GO:0004739
Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
5 Q47US5 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS)
Aldehyde-lyase activity GO:0016832
Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
2 Q886B1 (/ISS) Q886B1 (/ISS)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
1 Q608B0 (/ISS)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
6 P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA)
Acetyl-CoA biosynthetic process from pyruvate GO:0006086
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
5 Q47US5 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
2 Q886B1 (/ISS) Q886B1 (/ISS)
Carbohydrate utilization GO:0009758
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism.
1 Q608B0 (/ISS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
133 O74770 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA)
(123 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
132 P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA) P0AFG8 (/HDA)
(122 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
6 P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
6 P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA) P9WIS9 (/HDA)
Pyruvate dehydrogenase complex GO:0045254
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
6 P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA) P9WIS9 (/IDA)
Cytosolic pyruvate dehydrogenase complex GO:0045250
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
5 Q47US5 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS) Q9KPF4 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O74770 (/HDA)
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