The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"NAD(P)-binding Rossmann-like Domain
".
FunFam 60: Malic enzyme
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
|
9 | E1JIZ4 (/ISS) E1JIZ5 (/ISS) P06801 (/ISS) P13697 (/ISS) P48163 (/ISS) Q29558 (/ISS) Q8BMF3 (/ISS) Q9U1J0 (/ISS) Q9VB69 (/ISS) |
|
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
|
5 | A0A060X1Z3 (/IDA) A0A060XDT5 (/IDA) P13697 (/IDA) P48163 (/IDA) Q16798 (/IDA) |
|
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
|
4 | P06801 (/ISS) P13697 (/ISS) Q29558 (/ISS) Q8BMF3 (/ISS) |
|
Malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
|
4 | P06801 (/IDA) P13697 (/IDA) P48163 (/IDA) Q16798 (/IDA) |
|
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
|
3 | P06801 (/ISO) Q8BMF3 (/ISO) Q99KE1 (/ISO) |
|
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
3 | P06801 (/ISS) P13697 (/ISS) Q29558 (/ISS) |
|
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
|
2 | P23368 (/IMP) P48163 (/IMP) |
|
Malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
|
2 | P06801 (/ISO) Q8BMF3 (/ISO) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
2 | P23368 (/TAS) P48163 (/TAS) |
|
Malate dehydrogenase (decarboxylating) (NAD+) activity GO:0004471
Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.
|
1 | P23368 (/TAS) |
Showing 1 to 10 of 20 entries
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
|
8 | E1JIZ4 (/ISS) E1JIZ5 (/ISS) P06801 (/ISS) P13697 (/ISS) Q29558 (/ISS) Q8BMF3 (/ISS) Q9U1J0 (/ISS) Q9VB69 (/ISS) |
|
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
|
5 | E1JIZ4 (/ISS) E1JIZ5 (/ISS) Q8BMF3 (/ISS) Q9U1J0 (/ISS) Q9VB69 (/ISS) |
|
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
3 | P06801 (/ISS) P48163 (/ISS) Q29558 (/ISS) |
|
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
|
2 | P23368 (/TAS) Q16798 (/TAS) |
|
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
|
2 | P48163 (/IDA) Q16798 (/IDA) |
|
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
|
2 | P06801 (/ISO) Q8BMF3 (/ISO) |
|
Regulation of NADP metabolic process GO:1902031
Any process that modulates the frequency, rate or extent of NADP metabolic process.
|
2 | P23368 (/IMP) P48163 (/IMP) |
|
Regulation of NADP metabolic process GO:1902031
Any process that modulates the frequency, rate or extent of NADP metabolic process.
|
2 | P06801 (/ISO) Q99KE1 (/ISO) |
|
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
|
1 | P48163 (/NAS) |
|
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
|
1 | Q16798 (/IDA) |
Showing 1 to 10 of 24 entries
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | P06801 (/HDA) Q8BMF3 (/HDA) Q99KE1 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | F1N3V0 (/IDA) P13697 (/IDA) P23368 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P06801 (/ISS) P48163 (/ISS) Q29558 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P06801 (/ISO) Q99KE1 (/ISO) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | P23368 (/TAS) Q16798 (/TAS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q16798 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P13697 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P06801 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P48163 (/TAS) |
Showing 1 to 9 of 9 entries
