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CATH Superfamily 3.40.50.410

von Willebrand factor, type A domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
von Willebrand factor, type A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Collagen, type XII, alpha 1
1555 - - 93.2
2
Integrin beta
1287
3D
 5ffoF00 - 92.4
3
Collagen type VI alpha 3 chain
1237 - - 99.1
4
collagen alpha-6
VI
1145 - - 99.1
5
26S proteasome non-ATPase regulatory subunit 4
589
3D
 2x5nA01 - 87.8
6
voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1
540 - - 75.6
7
Calcium voltage-gated channel auxiliary subunit alpha2delta 3
482 - - 90.4
12
Integrin, alpha 10
456
3D
 6ndhR00 - 96.5
8
Protein transport protein SEC23
456
3D
 2qtvA03 - 91.3
9
Putative vitrin
432 - - 91.3
11
Protein transport protein SEC23
415
3D
 5vnoA03 - 79.7
10
Integrator complex subunit 6 like
410 - - 94.7
13
inter-alpha-trypsin inhibitor heavy chain H2
342 - - 84.2
14
von Willebrand and RING finger domain protein
279 - - 60.3
15
General transcription factor IIH subunit 2
278
3D
 4wfqA00 - 92.0
17
Anthrax toxin receptor 1
271
3D
 6cx1E00 - 71.7
16
Collagen type VI alpha 3 chain
269 - - 97.2
18
Matrilin 1
246 - - 83.0
19
SEC24 homolog B, COPII coat complex component
238
3D
 5vnoB04 - 76.6
20
protein transport protein Sec24D isoform X1
220
3D
 5kyyB04 - 86.7
21
Collagen, type VI, alpha 3
207 - - 97.9
22
Collagen type VI alpha 3 chain
206 - - 84.0
24
Anthrax toxin receptor
190
3D
 1t6bY00 - 96.4
23
Collagen type VI alpha 3 chain
190
3D
 4ihkA00 - 73.1
25
Vitrin
176 - - 74.5
26
Collagen, type VI, alpha 1
162 - - 93.8
27
collagen alpha-2
VI
159 - - 84.3
31
X-ray repair cross-complementing protein 6 isoform X1
156
3D
 6erhC01 - 87.9
28
Midasin
156 - - 90.5
29
Cochlin
148 - - 89.2
30
Protein ViaA
147 - - 4.7
33
60 kDa SS-A/Ro ribonucleoprotein
145
3D
 2i91B01 - 93.3
32
Hemicentin 1
144 - - 68.7
34
calcium-activated chloride channel regulator 1
138 - - 89.2
35
collagen alpha-3
VI
135 - - 78.7
36
Integrin beta
132 - - 79.2
37
Collagen type VI alpha 3 chain
131 - - 65.6
38
integrator complex subunit 14 isoform X1
126 - - 71.8
39
VWFA and cache domain-containing protein 1
125 - - 72.6
40
60 kDa SS-A/Ro ribonucleoprotein isoform X1
120 - - 78.4
41
Collagen alpha-1
XXI
117 - - 74.1
42
Copine 4
117 - - 48.8
43
Protein transport protein SEC23
102 - - 96.1
44
Collagen type VI alpha 6 chain
100 - - 87.5
45
general transcription factor IIH subunit 3 isoform X1
95 - - 83.9
46
von Willebrand factor A domain-containing protein 1
86 - - 82.5
47
von Willebrand factor A domain containing 2
84 - - 96.6
48
von Willebrand factor A domain-related protein
77 - - 47.4
56
Complement factor B
76
3D
 2xwjL03 - 68.1
49
von Willebrand factor A domain containing 8
75 - - 35.3
53
von Willebrand factor
75
3D
 3zqkC00 - 49.8
50
Collagen, type VI, alpha 1
71 - - 78.5
61
von Willebrand factor
70
3D
 5bv8A00 - 48.7
55
X-ray repair cross-complementing protein 5
68
3D
 6erfD01 - 88.4
51
Collagen type XXVIII alpha 1 chain
68 - - 93.2
52
collagen alpha-2
VI
67 - - 87.0
54
von Willebrand factor A domain containing 2
66 - - 93.9
57
Protein transport protein SEC23
59 - - 52.8
63
von Willebrand factor
59
3D
 4dmuL00 - 46.7
58
von Willebrand factor A domain containing 2
56 - - 83.1
59
Calcium-activated chloride channel regulator 2
56 - - 80.9
60
Collagen, type VI, alpha 1
53 - - 78.3
62
Uncharacterized protein, isoform C
49 - - 66.8
65
Complement C2
46
3D
 2i6sA01 - 31.9
64
RNA polymerase II transcription factor B subunit 4
45 - - 80.0
66
von Willebrand factor, type A
39 - - 37.6
67
Integrin alpha M
38 - - 75.4
69
von Willebrand factor A domain containing 5A
36 - - 51.4
68
ATP-dependent DNA helicase 2 subunit KU70
36 - - 74.2
70
sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
35 - - 30.1
71
ATP-dependent DNA helicase II subunit 1
34 - - 84.5
72
collagen alpha-1
VII
33 - - 76.9
73
ATP-dependent DNA helicase II subunit 2
29 - - 89.8
75
Sporozoite surface protein 2
28
3D
 4hqfA00 - 16.2
74
Mediator complex subunit 25
28 - - 16.5
81
Vesicle coat component
28
3D
 1pd1A04 - 59.6
76
general transcription factor IIH subunit 3
26 - - 71.6
77
Uncharacterized protein, isoform B
25 - - 18.7
79
Mg-protoporphyrin IX chelatase
24 - - 29.6
84
Transcription factor TFIIH subunit Tfb4, putative
24
3D
 5obzA00 - 79.2
80
X-ray repair-complementing defective repair in Chinese hamster cells 6
24 - - 90.7
78
UPF0353 protein RN09_1826
24 - - 26.3
82
Collagen type VI alpha 5 chain
23 - - 95.1
83
Poly [ADP-ribose] polymerase
22 - - 35.4
86
Circumsporozoite-and TRAP-related protein
20 - - 8.1
85
Circumsporozoite-and TRAP-related protein
20 - - 5.2
88
RNA polymerase II transcription factor B subunit 4
19 - - 4.8
87
TRAP-like protein
19 - - 6.9
90
Secretory 24AB, isoform A
18 - - 19.6
89
Protein transport protein Sec24A
18 - - 4.0
91
General transcription factor IIH subunit
18 - - 1.9
92
Midasin
17 - - 74.9
93
Transcription initiation factor TFIIH subunit
17 - - 80.3
94
Voltage-dependent calcium channel subunit alpha-2/delta-3
17 - - 2.9
95
Dihydropyridine-sensitive l-type calcium channel
17 - - 72.4
96
Integrin beta
16 - - 47.0
97
Protein transport protein Sec24-like CEF
16 - - 16.4
98
Copine-5
15 - - 83.0
101
General transcription factor IIH subunit, putative
14 - - 66.2
100
Inter alpha-trypsin inhibitor, heavy chain-like protein
14 - - 49.1
99
Yku70p
14 - - 85.0
102
ATP-dependent DNA helicase 2 subunit KU80
13 - - 78.4
103
Sec23/sec24 transport family protein
12 - - 8.6
108
Sfb3p
11 - - 9.7
109
Protein transport protein SEC23
11 - - 78.1
106
Nitric oxide reductase D protein
11 - - 63.7
107
Putative ribonucleoprotein related-protein
11 - - 2.9
104
Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence
11 - - 20.0
105
Mesocentin
11 - - 38.7
112
TFIIH basal transcription factor subunit
10 - - 40.6
114
Midasin
10 - - 73.9
110
Protein CBR-DIG-1
10 - - 41.9
111
Uncharacterized protein
10 - - 92.2
113
Protein CBR-CUT-6
10 - - 7.0
121
Midasin, putative
9 - - 4.6
115
Retroelement pol polyprotein-like
9 - - 36.5
117
Protein CBR-TAG-180
9 - - 8.7
118
Collagen type VI alpha 6 chain
9 - - 74.7
119
Midasin
9 - - 72.9
116
Voltage-dependent calcium channel unc-36
9 - - 24.4
120
Complement factor B
9 - - 93.6
127
60 kDa SS-A/Ro ribonucleoprotein homolog
8 - - 85.1
123
Protein transport protein SEC23
8 - - 5.8
128
26S proteasome regulatory subunit S5A
AFU_orthologue AFUA_2G15070
8 - - 46.3
126
Voltage-dependent calcium channel subunit alpha-2/delta-1
8 - - 12.4
122
Mesocentin
8 - - 20.2
125
von Willebrand factor, type A
8 - - 0.6
124
ATP-dependent DNA helicase II subunit 2
8 - - 4.5
131
Uncharacterized protein
7 - - 7.3
133
Protein transport protein Sec24C, putative
7 - - 36.8
129
Probable E3 ubiquitin-protein ligase EDA40
7 - - 70.9
132
60 kDa SS-A/Ro ribonucleoprotein homolog
7 - - 14.7
134
Efk-1
7 - - 78.1
130
Inverted repeat-binding protein
7 - - 8.3
137
Integrator complex subunit 14
6 - - 34.5
139
Predicted protein
6 - - 15.8
141
Matrilin-4
6 - - 57.5
138
general transcription factor IIH subunit 3 isoform X2
6 - - 14.7
136
C-type LECtin
6 - - 88.5
135
Alpha-protein kinase vwkA
6 - - 76.0
140
Uncharacterized protein
Fragment
6 - - 89.7
142
Integrator complex subunit 6
6 - - 42.9
146
ATP-dependent DNA helicase II subunit 2
5 - - 89.5
143
ATP-dependent DNA helicase II subunit 2
5 - - 11.8
144
RNA polymerase II transcription factor B subunit, putative
5 - - 11.6
145
Telomerase-associated protein 1
5 - - 94.3
150
Protein BONZAI 2
4 - - 11.6
154
Uncharacterized protein
4 - - 3.6
148
Midasin
4 - - 68.3
149
Predicted protein
4 - - 63.5
147
Copine family protein
4 - - 69.9
155
Collagen, type VI, alpha 1
4 - - 12.0
152
TFIIH P44
4 - - 12.2
156
General Transcription Factor homolog
4 - - 52.9
158
Predicted protein
4 - - 71.0
159
Calcium voltage-gated channel auxiliary subunit alpha2delta 2
4 - - 34.8
153
RfeF
4 - - 14.5
151
Uncharacterized protein
4 - - 11.0
157
Uncharacterized protein
4 - - 77.6
164
LOC553407 protein
3 - - 47.7
183
Predicted protein
3 - - 22.5
160
Caenorhabditis KU
3 - - 21.8
170
Collagen, type VI, alpha 1
3 - - 3.1
174
Matrilin 1
3 - - 13.7
181
Uncharacterized protein
3 - - 8.8
165
Predicted protein
3 - - 73.7
186
Uncharacterized protein
3 - - 68.4
175
Complement factor B
3 - - 2.1
162
Predicted protein
3 - - 29.9
172
Uncharacterized protein
3 - - 3.9
166
Collagen, type VI, alpha 3
3 - - 9.4
185
Uncharacterized protein
3 - - 70.1
176
Copine-7
3 - - 38.9
169
Collagen type VI alpha 3 chain
3 - - 7.4
168
ATP-dependent DNA helicase
3 - - 8.9
182
Uncharacterized protein, isoform E
3 - - 2.1
179
von Willebrand factor type A domain protein
3 - - 0.8
178
Uncharacterized protein
3 - - 20.9
180
Epithelial chloride channel protein
3 - - 8.7
163
Integrin beta
3 - - 20.8
184
Proteasome 26S subunit, non-ATPase 4
3 - - 28.8
173
Collagen, type VI, alpha 1
3 - - 5.2
177
Uncharacterized protein
3 - - 69.6
161
Mesocentin
3 - - 16.8
167
Collagen, type VI, alpha 1
3 - - 3.1
171
Tellurium resistance protein
3 - - 5.0
254
ANTXR cell adhesion molecule 1d
2 - - 0.0
260
Predicted protein
2 - - 34.8
237
Integrator complex subunit 14
2 - - 1.4
264
Integrin beta
2 - - 40.6
250
Uncharacterized protein
2 - - 0.0
212
Putative KU70 protein
2 - - 10.2
227
Collagen alpha-1
XIV
2 - - 11.2
208
Voltage-dependent calcium channel subunit alpha-2/delta-1
2 - - 0.0
209
Ku70-like protein
2 - - 0.6
221
Collagen, type VI, alpha 4a
2 - - 0.0
248
Methanol oxidation protein
2 - - 0.0
231
Predicted protein
2 - - 47.2
249
Uncharacterized protein
2 - - 0.0
215
Collagen, type VI, alpha 4a
2 - - 0.0
194
Collagen, type VII, alpha 1
2 - - 28.8
187
ATP-dependent DNA helicase II subunit 2
2 - - 2.1
223
Uncharacterized protein
2 - - 0.0
206
DNA binding protein
2 - - 0.0
190
Circularly permutated Ras protein 1
2 - - 14.7
246
60-kDa SS-A/Ro ribonucleoprotein homolog
2 - - 8.1
233
Uncharacterized protein
2 - - 0.0
247
General transcription and DNA repair factor IIH subunit TFB4
2 - - 0.0
255
Predicted protein
2 - - 12.6
207
Cku-70
2 - - 0.0
265
Predicted protein
2 - - 40.6
201
Predicted protein
2 - - 45.1
229
Predicted protein
2 - - 31.7
192
Integrin beta
2 - - 28.1
228
Uncharacterized protein
2 - - 12.5
241
Uncharacterized protein
2 - - 9.6
239
Uncharacterized protein
2 - - 0.0
238
TROVE domain protein
2 - - 0.0
252
Cutl-23
2 - - 0.0
210
ATP-dependent DNA helicase II subunit 1
2 - - 0.0
214
ATP-dependent DNA helicase II subunit 1
2 - - 0.0
262
Uncharacterized protein
2 - - 38.1
188
Uncharacterized protein
2 - - 0.0
189
ATP-dependent DNA helicase 2 subunit KU80
2 - - 6.1
226
AGAP009043-PA
2 - - 10.0
203
KU80 protein
2 - - 0.0
195
Protein transport protein SEC23
2 - - 29.2
236
von Willebrand factor type A domain containing protein, putative
2 - - 0.0
243
VWA domain containing CoxE-like protein
2 - - 12.9
256
Voltage-dependent calcium channel subunit alpha-2/delta-3
2 - - 2.0
211
von Willebrand factor
2 - - 0.0
266
Uncharacterized protein
2 - - 42.9
217
Uncharacterized protein
2 - - 0.0
222
Midasin
2 - - 6.0
198
Integrin beta
2 - - 49.9
199
Protein transport protein SEC23
2 - - 37.5
232
Putative 60 kd ribonucleoprotein ssa/ro60 kd ribonucleoprotein ssa/ro
2 - - 9.0
258
Voltage-dependent calcium channel subunit alpha-2/delta-4
2 - - 0.0
259
Uncharacterized protein
2 - - 11.4
213
ATP-dependent DNA helicase
2 - - 0.0
204
ATP-dependent DNA helicase II subunit 2
2 - - 0.0
225
Integrin beta
2 - - 12.0
196
Uncharacterized protein
2 - - 39.7
240
Uncharacterized protein
2 - - 2.7
244
Uncharacterized protein
2 - - 7.4
235
DumPY: shorter than wild-type
2 - - 0.0
200
ATP-dependent DNA helicase II subunit 2
2 - - 41.2
253
ANTXR cell adhesion molecule 1d
2 - - 0.0
218
Uncharacterized protein
2 - - 0.0
197
Integrin beta
2 - - 42.8
219
ABL030Wp
2 - - 4.2
263
Calcium voltage-gated channel auxiliary subunit alpha2delta 4
2 - - 40.8
191
Protein transport protein SEC23
2 - - 28.2
202
ATP-dependent DNA helicase II subunit 1
2 - - 0.5
242
integrator complex subunit 14
2 - - 0.0
251
Cutl-23
2 - - 0.0
261
Predicted protein
2 - - 31.9
216
von Willebrand factor
2 - - 0.0
193
Ubiquitin-conjugating enzyme family protein
2 - - 30.7
230
Uncharacterized protein
2 - - 37.8
267
Collagen, type XII, alpha 1b
2 - - 41.0
205
Integrin beta
2 - - 0.0
224
Integrin beta
2 - - 3.5
220
von Willebrand factor
2 - - 0.0
257
voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1
2 - - 2.3
234
Predicted protein
2 - - 0.0
245
Uncharacterized protein
2 - - 2.4
317
Uncharacterized protein
1 - - 0.0
322
Uncharacterized protein
1 - - 0.0
283
Uncharacterized protein
1 - - 0.0
376
Voltage-dependent calcium channel subunit alpha-2/delta-4-like Protein
1 - - 0.0
332
Sec24-related gene family, member C
S. cerevisiae
1 - - 0.0
274
Uncharacterized protein
1 - - 0.0
356
Uncharacterized protein
1 - - 0.0
311
Uncharacterized protein
1 - - 0.0
366
General transcription and DNA repair factor IIH subunit tfb4
1 - - 0.0
270
DNA binding protein
1 - - 0.0
281
Integrin beta
1 - - 0.0
304
Serine/threonine protein kinase PpkA
1 - - 0.0
325
Integrin beta
1 - - 0.0
379
Uncharacterized protein
1 - - 0.0
378
Uncharacterized protein
1 - - 0.0
340
Anthrax toxin receptor
1 - - 0.0
344
Uncharacterized protein
1 - - 0.0
335
Uncharacterized protein
1 - - 0.0
300
Integrin beta
1 - - 0.0
358
Uncharacterized protein
1 - - 0.0
359
Protein transport protein SEC23
1 - - 0.0
290
X-ray repair cross-complementing protein 5-like Protein
1 - - 0.0
294
Predicted protein
1 - - 0.0
287
KU70 protein
1 - - 0.0
369
Uncharacterized protein
1 - - 0.0
313
Phospholipase A
2
1 - - 0.0
368
Uncharacterized protein
1 - - 0.0
373
Predicted protein
1 - - 0.0
302
ATP dependent DNA ligase 1
1 - - 0.0
286
Integrin beta
1 - - 0.0
342
Uncharacterized protein
1 - - 0.0
275
ATP-dependent DNA helicase II subunit 2
1 - - 0.0
353
Uncharacterized protein
1 - - 0.0
318
Uncharacterized protein
1 - - 0.0
363
Uncharacterized protein
1 - - 0.0
319
Collagen, type XIV, alpha 1a
1 - - 0.0
292
Collagen type VI alpha 3 chain
1 - - 0.0
380
Collagen alpha 3 chain type VI
1 - - 0.0
288
Inverted repeat-binding protein
1 - - 0.0
330
Chloride channel accessory 3, pseudogene
1 - - 0.0
371
60 kDa SS-A/Ro ribonucleoprotein homolog
1 - - 0.0
367
MxaL protein
1 - - 0.0
289
Uncharacterized protein
1 - - 0.0
305
Integrin beta
1 - - 0.0
324
60 kDa SS-A/Ro ribonucleoprotein-like Protein
1 - - 0.0
357
Vwa2 protein
1 - - 0.0
320
Integrin beta
1 - - 0.0
334
Uncharacterized protein
1 - - 0.0
345
Integrin beta
1 - - 0.0
351
Uncharacterized protein
1 - - 0.0
272
Uncharacterized protein
1 - - 0.0
361
Collagen, type VI, alpha 3
1 - - 0.0
377
Calcium voltage-gated channel auxiliary subunit alpha2delta 3
1 - - 0.0
295
Predicted protein
1 - - 0.0
316
Predicted protein
1 - - 0.0
308
Uncharacterized protein
1 - - 0.0
374
Uncharacterized protein
1 - - 0.0
309
Uncharacterized protein
1 - - 0.0
321
Uncharacterized protein
1 - - 0.0
285
Integrin beta
1 - - 0.0
348
Protein transport protein SEC23
1 - - 0.0
370
Predicted protein
1 - - 0.0
331
Uncharacterized protein
1 - - 0.0
349
Uncharacterized protein
1 - - 0.0
354
Uncharacterized protein
1 - - 0.0
276
Protein transport protein SEC23
1 - - 0.0
360
TFIIH 34kDa subunit
1 - - 0.0
337
Uncharacterized protein
1 - - 0.0
298
Ubiquitin-conjugating enzyme family protein
1 - - 0.0
364
Uncharacterized protein
1 - - 0.0
312
Uncharacterized protein
1 - - 0.0
299
Sec24d protein
1 - - 0.0
327
Uncharacterized protein
1 - - 0.0
350
Uncharacterized protein
1 - - 0.0
323
Protein transport protein SEC23
1 - - 0.0
282
Uncharacterized protein
1 - - 0.0
306
Uncharacterized protein
1 - - 0.0
269
Uncharacterized protein
1 - - 0.0
268
Uncharacterized protein
1 - - 0.0
333
AGAP001871-PA
1 - - 0.0
346
Proteasome 26S subunit, non-ATPase 4
1 - - 0.0
279
Integrin beta
1 - - 0.0
278
Uncharacterized protein
1 - - 0.0
296
Ubiquitin interaction motif family protein
1 - - 0.0
315
Integrin beta
1 - - 0.0
301
Uncharacterized protein
1 - - 0.0
297
Poly [ADP-ribose] polymerase
1 - - 0.0
329
Uncharacterized protein
1 - - 0.0
284
Protein transport protein SEC23
1 - - 0.0
375
voltage-dependent calcium channel subunit alpha-2/delta-1
1 - - 0.0
328
Protein transport protein SEC23
1 - - 0.0
341
Integrin beta-like protein C
1 - - 0.0
339
Uncharacterized protein
1 - - 0.0
338
Predicted protein
1 - - 0.0
280
Uncharacterized protein
1 - - 0.0
347
Uncharacterized protein
1 - - 0.0
355
Uncharacterized protein
1 - - 0.0
273
Uncharacterized protein
1 - - 0.0
307
Uncharacterized protein
1 - - 0.0
291
Uncharacterized protein
1 - - 0.0
365
Type IV pili system adhesin PilY
1 - - 0.0
326
TFIIH P34
1 - - 0.0
303
Uncharacterized protein
1 - - 0.0
372
Uncharacterized protein
1 - - 0.0
343
Uncharacterized protein
1 - - 0.0
336
Fibronectin binding protein
1 - - 0.0
277
Integrin beta
1 - - 0.0
271
Predicted protein
1 - - 0.0
310
Mesocentin
1 - - 0.0
352
Uncharacterized protein
1 - - 0.0
314
Integrin beta
1 - - 0.0
293
Predicted protein
1 - - 0.0
362
Bcl-2-associated transcription factor
BTF
1 - - 0.0
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