The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 88: Ras-related C3 botulinum toxin substrate 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 32 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
308 P15153 (/IPI) P15153 (/IPI) P15153 (/IPI) P15153 (/IPI) P15153 (/IPI) P15153 (/IPI) P15153 (/IPI) P15153 (/IPI) P15153 (/IPI) P15153 (/IPI)
(298 more)
Rho GDP-dissociation inhibitor binding GO:0051022
Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein.
216 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(206 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
207 P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA)
(197 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
164 P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA)
(154 more)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
129 P34144 (/IPI) P34145 (/IPI) P34146 (/IPI) P40792 (/IPI) P40792 (/IPI) P40792 (/IPI) P40792 (/IPI) P40792 (/IPI) P40792 (/IPI) P40792 (/IPI)
(119 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
108 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(98 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
83 P60764 (/ISO) P60764 (/ISO) P60764 (/ISO) P60764 (/ISO) P60764 (/ISO) P60764 (/ISO) P60764 (/ISO) P60764 (/ISO) P60764 (/ISO) P60764 (/ISO)
(73 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
83 P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS)
(73 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
65 P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP)
(55 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
56 P63001 (/ISO) P63001 (/ISO) P63001 (/ISO) P63001 (/ISO) P63001 (/ISO) P63001 (/ISO) P63001 (/ISO) P63001 (/ISO) P63001 (/ISO) P63001 (/ISO)
(46 more)
Showing 1 to 10 of 32 entries

There are 317 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
216 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(206 more)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
216 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(206 more)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
216 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(206 more)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
216 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(206 more)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
162 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(152 more)
Positive regulation of lamellipodium assembly GO:0010592
Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
121 P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP)
(111 more)
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
121 P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP) P15153 (/IMP)
(111 more)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
108 P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP)
(98 more)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
108 P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP)
(98 more)
Ruffle assembly GO:0097178
The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.
108 P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP) P63000 (/IMP)
(98 more)
Showing 1 to 10 of 317 entries

There are 77 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
216 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(206 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
202 P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS) P15153 (/TAS)
(192 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
178 A2BHI1 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA) P40792 (/IDA)
(168 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
162 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(152 more)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
162 P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS) P62998 (/ISS)
(152 more)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
119 P15153 (/IDA) P15153 (/IDA) P15153 (/IDA) P15153 (/IDA) P15153 (/IDA) P15153 (/IDA) P15153 (/IDA) P15153 (/IDA) P15153 (/IDA) P15153 (/IDA)
(109 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
111 G1SY93 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA)
(101 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
110 P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA)
(100 more)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
109 P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA) P63001 (/IDA)
(99 more)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
108 P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA) P63000 (/IDA)
(98 more)
Showing 1 to 10 of 77 entries
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