The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 446: ATP-dependent RNA helicase SUPV3L1, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
8 A4IG62 (/ISS) Q17828 (/ISS) Q295E6 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q61SU7 (/ISS) Q80YD1 (/ISS) Q9VN03 (/ISS)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
8 A4IG62 (/ISS) Q17828 (/ISS) Q295E6 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q61SU7 (/ISS) Q80YD1 (/ISS) Q9VN03 (/ISS)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
3'-5' RNA helicase activity GO:0034458
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q8IYB8 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q80YD1 (/ISO)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
1 Q8IYB8 (/IMP)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
1 Q80YD1 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8IYB8 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8IYB8 (/TAS)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
1 Q8IYB8 (/IDA)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
1 Q80YD1 (/ISO)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 Q8IYB8 (/IDA)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 Q80YD1 (/ISO)
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
1 Q8IYB8 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8IYB8 (/IPI)
3'-5' RNA helicase activity GO:0034458
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'.
1 Q8IYB8 (/IDA)
3'-5' RNA helicase activity GO:0034458
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'.
1 Q80YD1 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8IYB8 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q80YD1 (/ISO)

There are 48 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
8 A4IG62 (/ISS) Q17828 (/ISS) Q295E6 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q61SU7 (/ISS) Q80YD1 (/ISS) Q9VN03 (/ISS)
Mitochondrial mRNA catabolic process GO:0000958
The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Positive regulation of mitochondrial RNA catabolic process GO:0000962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Mitochondrial RNA 3'-end processing GO:0000965
Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Mitochondrial ncRNA surveillance GO:0035945
The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Mitochondrial mRNA surveillance GO:0035946
The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Chromatin maintenance GO:0070827
The chromatin organization process that preserves chromatin in a stable functional or structural state.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Mitochondrial RNA surveillance GO:2000827
The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Mitochondrial mRNA catabolic process GO:0000958
The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
1 Q8IYB8 (/IMP)
Mitochondrial mRNA catabolic process GO:0000958
The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
1 Q80YD1 (/ISO)
Positive regulation of mitochondrial RNA catabolic process GO:0000962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
1 Q8IYB8 (/IDA)
Positive regulation of mitochondrial RNA catabolic process GO:0000962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
1 Q8IYB8 (/IMP)
Positive regulation of mitochondrial RNA catabolic process GO:0000962
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.
1 Q80YD1 (/ISO)
Mitochondrial RNA processing GO:0000963
The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.
1 Q9VN03 (/IMP)
Mitochondrial RNA 3'-end processing GO:0000965
Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
1 Q8IYB8 (/IMP)
Mitochondrial RNA 3'-end processing GO:0000965
Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
1 Q80YD1 (/ISO)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 A4IG62 (/IMP)
Oxidative phosphorylation GO:0006119
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
1 Q9VN03 (/IMP)
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
1 Q8IYB8 (/IMP)
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
1 Q80YD1 (/ISO)
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1 Q8IYB8 (/IMP)
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1 Q80YD1 (/ISO)
Respiratory electron transport chain GO:0022904
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
1 Q9VN03 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 Q8IYB8 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 Q80YD1 (/ISO)
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
1 Q8IYB8 (/IMP)
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
1 Q80YD1 (/ISO)
Mitochondrial ncRNA surveillance GO:0035945
The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion.
1 Q8IYB8 (/IMP)
Mitochondrial ncRNA surveillance GO:0035945
The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion.
1 Q80YD1 (/ISO)
Mitochondrial mRNA surveillance GO:0035946
The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion.
1 Q8IYB8 (/IMP)
Mitochondrial mRNA surveillance GO:0035946
The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion.
1 Q80YD1 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q8IYB8 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q80YD1 (/ISO)
Regulation of mitochondrial mRNA stability GO:0044528
Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.
1 Q9VN03 (/IMP)
Positive regulation of mitochondrial translation GO:0070131
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
1 Q9VN03 (/IMP)
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
1 Q8IYB8 (/IMP)
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
1 Q80YD1 (/ISO)
Chromatin maintenance GO:0070827
The chromatin organization process that preserves chromatin in a stable functional or structural state.
1 Q8IYB8 (/IMP)
Chromatin maintenance GO:0070827
The chromatin organization process that preserves chromatin in a stable functional or structural state.
1 Q80YD1 (/ISO)
Mitochondrial tRNA processing GO:0090646
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion.
1 Q9VN03 (/IMP)
Mitochondrial mRNA polyadenylation GO:0097222
The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails.
1 Q9VN03 (/IMP)
Mitochondrial RNA surveillance GO:2000827
The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion.
1 Q8IYB8 (/IMP)
Mitochondrial RNA surveillance GO:2000827
The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion.
1 Q80YD1 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
8 A4IG62 (/ISS) Q17828 (/ISS) Q295E6 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q61SU7 (/ISS) Q80YD1 (/ISS) Q9VN03 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Mitochondrial degradosome GO:0045025
A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
4 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS) Q80YD1 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 A4IG62 (/ISS) Q5EBA1 (/ISS) Q5ZJT0 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8IYB8 (/IDA) Q9VN03 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8IYB8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q80YD1 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q80YD1 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q80YD1 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8IYB8 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8IYB8 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q80YD1 (/ISO)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
1 Q8IYB8 (/IDA)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
1 Q80YD1 (/ISO)
Mitochondrial degradosome GO:0045025
A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
1 Q8IYB8 (/IDA)
Mitochondrial degradosome GO:0045025
A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
1 Q80YD1 (/ISO)
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