The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 346: RAB31, member RAS oncogene family
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | P35285 (/IPI) P35285 (/IPI) Q13636 (/IPI) Q6GQP4 (/IPI) Q921E2 (/IPI) Q9UL26 (/IPI) |
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
5 | P35285 (/ISS) P35285 (/ISS) P51154 (/ISS) Q6GQP4 (/ISS) Q921E2 (/ISS) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
3 | P35285 (/IDA) P35285 (/IDA) Q13636 (/IDA) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
3 | P35285 (/ISO) P35285 (/ISO) Q921E2 (/ISO) |
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
3 | P35285 (/ISO) P35285 (/ISO) Q921E2 (/ISO) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
2 | P35285 (/IDA) P35285 (/IDA) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
2 | P35285 (/ISO) P35285 (/ISO) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
2 | Q13636 (/TAS) Q9UL26 (/TAS) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
2 | Q6GQP4 (/ISS) Q921E2 (/ISS) |
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
2 | Q13636 (/IDA) Q9UL26 (/IDA) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
1 | Q9UL26 (/IMP) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | Q9UL26 (/IMP) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
|
2 | P35285 (/ISO) P35285 (/ISO) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
2 | Q6GQP4 (/ISS) Q921E2 (/ISS) |
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
2 | Q6GQP4 (/ISS) Q921E2 (/ISS) |
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
|
2 | Q6GQP4 (/ISS) Q921E2 (/ISS) |
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
|
2 | Q6GQP4 (/ISS) Q921E2 (/ISS) |
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
|
2 | Q13636 (/ISS) Q6GQP4 (/ISS) |
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
|
2 | Q6GQP4 (/ISS) Q921E2 (/ISS) |
Regulation of vesicle size GO:0097494
Any process that modulates the size of a vesicle.
|
2 | P35285 (/ISO) P35285 (/ISO) |
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
|
1 | Q9UL26 (/IDA) |
Endosome organization GO:0007032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
|
1 | Q9UL26 (/IEP) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
1 | Q13636 (/IMP) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
1 | Q921E2 (/ISO) |
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | Q13636 (/IMP) |
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | Q921E2 (/ISO) |
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
|
1 | Q13636 (/IMP) |
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
|
1 | Q921E2 (/ISO) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | Q13636 (/TAS) |
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
|
1 | Q13636 (/IMP) |
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
|
1 | Q921E2 (/ISO) |
Golgi vesicle transport GO:0048193
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
|
1 | Q6GQP4 (/IMP) |
Golgi vesicle transport GO:0048193
The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
|
1 | Q921E2 (/ISO) |
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
|
1 | Q921E2 (/IMP) |
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
|
1 | Q13636 (/IMP) |
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
|
1 | Q921E2 (/ISO) |
Regulation of vesicle size GO:0097494
Any process that modulates the size of a vesicle.
|
1 | Q9UL26 (/IMP) |
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
|
5 | P35285 (/ISS) P35285 (/ISS) P51154 (/ISS) Q6GQP4 (/ISS) Q921E2 (/ISS) |
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
3 | P35285 (/ISO) P35285 (/ISO) Q921E2 (/ISO) |
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
|
3 | P35285 (/ISO) P35285 (/ISO) Q921E2 (/ISO) |
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
|
2 | Q13636 (/ISS) Q6GQP4 (/ISS) |
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
2 | Q13636 (/IDA) Q9UL26 (/IDA) |
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
2 | Q6GQP4 (/ISS) Q921E2 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P35285 (/ISO) P35285 (/ISO) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
2 | P35285 (/IDA) P35285 (/IDA) |
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
|
2 | Q6GQP4 (/ISS) Q921E2 (/ISS) |
Early phagosome membrane GO:0036186
The lipid bilayer surrounding an early phagosome.
|
2 | Q13636 (/ISS) Q6GQP4 (/ISS) |
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
|
2 | Q13636 (/IDA) Q9UL26 (/IDA) |
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
|
1 | Q921E2 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q921E2 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q13636 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9UL26 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q13636 (/TAS) |
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
|
1 | Q13636 (/TAS) |
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q13636 (/TAS) |
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
|
1 | Q13636 (/IDA) |
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
|
1 | Q921E2 (/ISO) |
Early phagosome membrane GO:0036186
The lipid bilayer surrounding an early phagosome.
|
1 | Q921E2 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9UL26 (/HDA) |