The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 247: ADP-ribosylation factor-like GTPase 8A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
|
81 |
Q2KI07 (/ISS)
Q4R4S4 (/ISS)
Q5R6E7 (/ISS)
Q66HA6 (/ISS)
Q66HA6 (/ISS)
Q66HA6 (/ISS)
Q66HA6 (/ISS)
Q66HA6 (/ISS)
Q66HA6 (/ISS)
Q66HA6 (/ISS)
(71 more) |
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
42 |
Q8VEH3 (/IDA)
Q8VEH3 (/IDA)
Q8VEH3 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
(32 more) |
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
39 |
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
(29 more) |
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
39 |
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
(29 more) |
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
|
39 |
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
Q9NVJ2 (/IMP)
(29 more) |
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
|
39 |
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
(29 more) |
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
35 |
Q96BM9 (/ISS)
Q96BM9 (/ISS)
Q96BM9 (/ISS)
Q96BM9 (/ISS)
Q96BM9 (/ISS)
Q96BM9 (/ISS)
Q96BM9 (/ISS)
Q96BM9 (/ISS)
Q96BM9 (/ISS)
Q96BM9 (/ISS)
(25 more) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
35 |
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
(25 more) |
Sister chromatid segregation GO:0000819
The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
|
6 | Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
6 | Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) |
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
|
6 | Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) |
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
6 | Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) |
Axonal transport GO:0098930
The directed movement of organelles or molecules along microtubules in axons.
|
6 | Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) |
Presynapse assembly GO:0099054
The aggregation, arrangement and bonding together of a set of components to form a presynapse.
|
6 | Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) |
Late endosome to lysosome transport GO:1902774
The directed movement of substances from late endosome to lysosome.
|
6 | Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) Q9VHV5 (/IMP) |
Axo-dendritic transport GO:0008088
The directed movement of organelles or molecules along microtubules in neuron projections.
|
2 | G5EDC6 (/IGI) G5EDC6 (/IGI) |
Axo-dendritic transport GO:0008088
The directed movement of organelles or molecules along microtubules in neuron projections.
|
2 | G5EDC6 (/IMP) G5EDC6 (/IMP) |
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
|
2 | G5EDC6 (/IMP) G5EDC6 (/IMP) |
Regulation of anterograde synaptic vesicle transport GO:1903742
Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport.
|
2 | G5EDC6 (/IDA) G5EDC6 (/IDA) |
Regulation of anterograde synaptic vesicle transport GO:1903742
Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport.
|
2 | G5EDC6 (/IMP) G5EDC6 (/IMP) |
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
74 |
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
(64 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
74 |
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
(64 more) |
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
|
74 |
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
(64 more) |
Spindle midzone GO:0051233
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
|
74 |
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
Q96BM9 (/IDA)
(64 more) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
74 |
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
(64 more) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
45 |
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
(35 more) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
45 |
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
Q9CQW2 (/IDA)
(35 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
42 |
Q8VEH3 (/ISO)
Q8VEH3 (/ISO)
Q8VEH3 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
(32 more) |
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
|
42 |
Q8VEH3 (/ISO)
Q8VEH3 (/ISO)
Q8VEH3 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
(32 more) |
Spindle midzone GO:0051233
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
|
42 |
Q8VEH3 (/ISO)
Q8VEH3 (/ISO)
Q8VEH3 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
Q9CQW2 (/ISO)
(32 more) |
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
37 |
B2R7U5 (/HDA)
B4E1J8 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
Q96BM9 (/HDA)
(27 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
35 |
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
(25 more) |
Azurophil granule membrane GO:0035577
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
|
35 |
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
(25 more) |
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
|
35 |
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
Q96BM9 (/TAS)
(25 more) |
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
8 | G5EDC6 (/IDA) G5EDC6 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) |
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
6 | Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) |
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
|
6 | Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) |
Extrinsic component of lysosome membrane GO:0032419
The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
6 | Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
6 | Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) |
Spindle midzone GO:0051233
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
|
6 | Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) Q9VHV5 (/ISS) |
S bouton GO:1990027
Synaptic bouton found in the ventral horn of the spinal cord. S boutons range in diameter from 0.5 to 8 um and contain spherical synaptic vesicles.
|
6 | Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) Q9VHV5 (/IDA) |
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
|
2 | G5EDC6 (/IDA) G5EDC6 (/IDA) |