The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 17: Disks large homolog 3 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 84 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
39 |
P31007 (/IPI)
P31016 (/IPI)
P70175 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
(29 more) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
29 |
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
(19 more) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
20 |
P31016 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
P78352 (/IPI)
(10 more) |
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
D1 dopamine receptor binding GO:0031748
Interacting selectively and non-covalently with a D1 dopamine receptor.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
P2Y1 nucleotide receptor binding GO:0031812
Interacting selectively and non-covalently with a P2Y1 nucleotide receptor.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Acetylcholine receptor binding GO:0033130
Interacting selectively and non-covalently with an acetylcholine receptor.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Neuroligin family protein binding GO:0097109
Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
|
14 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(4 more) |
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
|
13 |
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
(3 more) |
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
|
8 | P70175 (/ISS) Q3UP61 (/ISS) Q59FC4 (/ISS) Q5PYH5 (/ISS) Q5PYH6 (/ISS) Q62696 (/ISS) Q62936 (/ISS) Q811D0 (/ISS) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
6 | Q3UP61 (/ISS) Q59FC4 (/ISS) Q5PYH5 (/ISS) Q5PYH6 (/ISS) Q62696 (/ISS) Q811D0 (/ISS) |
Guanylate kinase activity GO:0004385
Catalysis of the reaction: ATP + GMP = ADP + GDP.
|
4 | P31007 (/TAS) Q12959 (/TAS) Q12959 (/TAS) Q15700 (/TAS) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
4 | P70175 (/ISO) Q62108 (/ISO) Q811D0 (/ISO) Q91XM9 (/ISO) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
4 | P70175 (/ISO) Q62108 (/ISO) Q811D0 (/ISO) Q91XM9 (/ISO) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
4 | P31016 (/IPI) Q12959 (/IPI) Q12959 (/IPI) Q62696 (/IPI) |
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
4 | P31016 (/IPI) Q62696 (/IPI) Q62936 (/IPI) Q63622 (/IPI) |
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
4 | P70175 (/ISO) Q62108 (/ISO) Q811D0 (/ISO) Q91XM9 (/ISO) |
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
|
4 | P31016 (/IPI) Q62108 (/IPI) Q62696 (/IPI) Q62936 (/IPI) |
Structural constituent of postsynaptic density GO:0098919
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
|
4 | P31016 (/IDA) Q62936 (/IDA) Q811D0 (/IDA) Q91XM9 (/IDA) |
Structural constituent of postsynaptic density GO:0098919
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
|
4 | P31016 (/IMP) Q62936 (/IMP) Q811D0 (/IMP) Q91XM9 (/IMP) |
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
3 | P31016 (/IPI) Q62936 (/IPI) Q63622 (/IPI) |
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
3 | P70175 (/ISO) Q62108 (/ISO) Q91XM9 (/ISO) |
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
|
3 | P70175 (/ISO) Q62108 (/ISO) Q811D0 (/ISO) |
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
|
2 | Q12959 (/TAS) Q12959 (/TAS) |
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
2 | Q12959 (/TAS) Q12959 (/TAS) |
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
2 | Q12959 (/ISS) Q12959 (/ISS) |
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
2 | Q12959 (/NAS) Q12959 (/NAS) |
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
|
2 | P31016 (/IPI) Q62696 (/IPI) |
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
|
2 | Q62108 (/ISO) Q811D0 (/ISO) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | Q62108 (/ISO) Q811D0 (/ISO) |
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
|
2 | Q12959 (/IPI) Q12959 (/IPI) |
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
|
2 | P70175 (/ISO) Q811D0 (/ISO) |
Mitogen-activated protein kinase kinase binding GO:0031434
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.
|
2 | Q12959 (/IPI) Q12959 (/IPI) |
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
|
2 | Q12959 (/IPI) Q12959 (/IPI) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
2 | Q12959 (/HDA) Q12959 (/HDA) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q63622 (/IPI) Q6R005 (/IPI) |
L27 domain binding GO:0097016
Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner.
|
2 | Q12959 (/IPI) Q12959 (/IPI) |
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
2 | P31016 (/IPI) Q62108 (/IPI) |
Structural constituent of postsynaptic density GO:0098919
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
|
2 | P70175 (/ISO) Q62108 (/ISO) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P31016 (/IPI) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q62108 (/ISO) |
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
|
1 | P31016 (/IPI) |
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
|
1 | Q62108 (/ISO) |
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
|
1 | P31007 (/TAS) |
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
|
1 | Q62108 (/NAS) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q62108 (/ISS) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q63622 (/TAS) |
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
1 | Q811D0 (/IMP) |
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
1 | Q811D0 (/ISO) |
Immunoglobulin binding GO:0019865
Interacting selectively and non-covalently with an immunoglobulin.
|
1 | P31016 (/IPI) |
Immunoglobulin binding GO:0019865
Interacting selectively and non-covalently with an immunoglobulin.
|
1 | Q62108 (/ISO) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q62936 (/IDA) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | P70175 (/ISO) |
Mitogen-activated protein kinase kinase binding GO:0031434
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.
|
1 | Q811D0 (/ISO) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | P70175 (/IPI) |
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
|
1 | P31016 (/IPI) |
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
|
1 | Q62108 (/ISO) |
Beta-2 adrenergic receptor binding GO:0031698
Interacting selectively and non-covalently with a beta-2 adrenergic receptor.
|
1 | P31016 (/IPI) |
Beta-2 adrenergic receptor binding GO:0031698
Interacting selectively and non-covalently with a beta-2 adrenergic receptor.
|
1 | Q62108 (/ISO) |
D1 dopamine receptor binding GO:0031748
Interacting selectively and non-covalently with a D1 dopamine receptor.
|
1 | P31016 (/IPI) |
D1 dopamine receptor binding GO:0031748
Interacting selectively and non-covalently with a D1 dopamine receptor.
|
1 | Q62108 (/ISO) |
P2Y1 nucleotide receptor binding GO:0031812
Interacting selectively and non-covalently with a P2Y1 nucleotide receptor.
|
1 | P31016 (/IPI) |
P2Y1 nucleotide receptor binding GO:0031812
Interacting selectively and non-covalently with a P2Y1 nucleotide receptor.
|
1 | Q62108 (/ISO) |
Acetylcholine receptor binding GO:0033130
Interacting selectively and non-covalently with an acetylcholine receptor.
|
1 | P31016 (/IDA) |
Acetylcholine receptor binding GO:0033130
Interacting selectively and non-covalently with an acetylcholine receptor.
|
1 | Q62108 (/ISO) |
Glutamate receptor binding GO:0035254
Interacting selectively and non-covalently with a glutamate receptor.
|
1 | P31016 (/IPI) |
Glutamate receptor binding GO:0035254
Interacting selectively and non-covalently with a glutamate receptor.
|
1 | Q62108 (/ISO) |
Neurexin family protein binding GO:0042043
Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.
|
1 | Q62108 (/NAS) |
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
|
1 | Q811D0 (/ISO) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | P31016 (/IPI) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q62108 (/ISO) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q91XM9 (/ISO) |
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
1 | Q811D0 (/IMP) |
L27 domain binding GO:0097016
Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner.
|
1 | Q811D0 (/ISO) |
Neuroligin family protein binding GO:0097109
Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.
|
1 | P31016 (/IPI) |
Neuroligin family protein binding GO:0097109
Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.
|
1 | Q62108 (/ISO) |
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
1 | Q62108 (/ISO) |
Structural constituent of postsynaptic density GO:0098919
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
|
1 | Q62108 (/IC) |
There are 217 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
30 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(20 more) |
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
|
30 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(20 more) |
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
|
27 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(17 more) |
Negative regulation of receptor internalization GO:0002091
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Synaptic vesicle maturation GO:0016188
Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
15 |
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
(5 more) |
Cellular response to potassium ion GO:0035865
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Regulation of long-term neuronal synaptic plasticity GO:0048169
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
AMPA glutamate receptor clustering GO:0097113
The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Receptor localization to synapse GO:0097120
Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Positive regulation of excitatory postsynaptic potential GO:2000463
Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
14 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(4 more) |
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
14 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(4 more) |
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
14 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(4 more) |
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
14 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(4 more) |
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
|
14 |
Q15700 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
Q92796 (/IDA)
(4 more) |
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
|
14 |
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
(4 more) |
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
14 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(4 more) |
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
|
14 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(4 more) |
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
14 |
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
(4 more) |
AMPA glutamate receptor clustering GO:0097113
The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.
|
14 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(4 more) |
Positive regulation of neuron projection arborization GO:0150012
Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
|
14 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(4 more) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
13 |
Q92796 (/NAS)
Q92796 (/NAS)
Q92796 (/NAS)
Q92796 (/NAS)
Q92796 (/NAS)
Q92796 (/NAS)
Q92796 (/NAS)
Q92796 (/NAS)
Q92796 (/NAS)
Q92796 (/NAS)
(3 more) |
Endothelial cell proliferation GO:0001935
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
|
6 | Q3UP61 (/ISS) Q59FC4 (/ISS) Q5PYH5 (/ISS) Q5PYH6 (/ISS) Q62696 (/ISS) Q811D0 (/ISS) |
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
6 | Q3UP61 (/ISS) Q59FC4 (/ISS) Q5PYH5 (/ISS) Q5PYH6 (/ISS) Q62696 (/ISS) Q811D0 (/ISS) |
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
6 | Q3UP61 (/ISS) Q59FC4 (/ISS) Q5PYH5 (/ISS) Q5PYH6 (/ISS) Q62696 (/ISS) Q811D0 (/ISS) |
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
|
6 | Q3UP61 (/ISS) Q59FC4 (/ISS) Q5PYH5 (/ISS) Q5PYH6 (/ISS) Q62696 (/ISS) Q811D0 (/ISS) |
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
6 | Q3UP61 (/ISS) Q59FC4 (/ISS) Q5PYH5 (/ISS) Q5PYH6 (/ISS) Q62696 (/ISS) Q811D0 (/ISS) |
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
|
5 | P70175 (/ISS) Q5PYH7 (/ISS) Q62936 (/ISS) Q63622 (/ISS) Q91XM9 (/ISS) |
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
4 | Q5PYH5 (/NAS) Q5PYH6 (/NAS) Q5PYH7 (/NAS) Q6R005 (/NAS) |
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
4 | Q5PYH5 (/NAS) Q5PYH6 (/NAS) Q5PYH7 (/NAS) Q6R005 (/NAS) |
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
|
4 | Q62108 (/IDA) Q62696 (/IDA) Q811D0 (/IDA) Q91XM9 (/IDA) |
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
|
4 | Q62108 (/IMP) Q62696 (/IMP) Q811D0 (/IMP) Q91XM9 (/IMP) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | P31007 (/IMP) Q12959 (/IMP) Q12959 (/IMP) |
Regulation of protein localization to synapse GO:1902473
Any process that modulates the frequency, rate or extent of protein localization to synapse.
|
3 | Q12959 (/IDA) Q12959 (/IDA) Q811D0 (/IDA) |
Endothelial cell proliferation GO:0001935
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Mitotic cell cycle checkpoint GO:0007093
A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
|
2 | Q12959 (/NAS) Q12959 (/NAS) |
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
|
2 | Q12959 (/TAS) Q12959 (/TAS) |
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
2 | P31007 (/IMP) Q91XM9 (/IMP) |
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
|
2 | P31007 (/IMP) Q811D0 (/IMP) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
|
2 | P70175 (/ISO) Q91XM9 (/ISO) |
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Astral microtubule organization GO:0030953
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Cellular protein-containing complex localization GO:0034629
A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Cellular response to potassium ion GO:0035865
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.
|
2 | Q62108 (/IDA) Q91XM9 (/IDA) |
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Positive regulation of potassium ion transport GO:0043268
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Cortical microtubule organization GO:0043622
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
|
2 | P31016 (/ISS) Q62108 (/ISS) |
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Establishment of centrosome localization GO:0051660
The directed movement of the centrosome to a specific location.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
|
2 | P31016 (/IMP) Q62936 (/IMP) |
Positive regulation of protein tyrosine kinase activity GO:0061098
Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
|
2 | P70175 (/ISO) Q62108 (/ISO) |
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
2 | P31016 (/ISS) Q62108 (/ISS) |
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
2 | Q12959 (/TAS) Q12959 (/TAS) |
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Regulation of ventricular cardiac muscle cell action potential GO:0098911
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
|
2 | Q12959 (/ISS) Q12959 (/ISS) |
Regulation of sodium ion transmembrane transport GO:1902305
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport.
|
2 | Q12959 (/TAS) Q12959 (/TAS) |
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Regulation of potassium ion import GO:1903286
Any process that modulates the frequency, rate or extent of potassium ion import.
|
2 | Q12959 (/ISS) Q12959 (/ISS) |
Negative regulation of p38MAPK cascade GO:1903753
Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.
|
2 | Q12959 (/IMP) Q12959 (/IMP) |
Regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1903760
Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.
|
2 | Q12959 (/ISS) Q12959 (/ISS) |
Regulation of potassium ion export across plasma membrane GO:1903764
Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane.
|
2 | Q12959 (/ISS) Q12959 (/ISS) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q811D0 (/ISO) |
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
|
1 | P31007 (/IGI) |
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
|
1 | Q811D0 (/IMP) |
Branching involved in ureteric bud morphogenesis GO:0001658
The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
|
1 | Q811D0 (/IMP) |
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
|
1 | P31007 (/IMP) |
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
|
1 | P70175 (/IMP) |
Morphogenesis of a polarized epithelium GO:0001738
The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
|
1 | P31007 (/TAS) |
Immunological synapse formation GO:0001771
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
1 | Q811D0 (/IMP) |
Endothelial cell proliferation GO:0001935
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
|
1 | Q811D0 (/ISO) |
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
|
1 | Q811D0 (/IMP) |
Negative regulation of receptor internalization GO:0002091
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.
|
1 | P31016 (/IDA) |
Negative regulation of receptor internalization GO:0002091
Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.
|
1 | Q62108 (/ISO) |
T cell cytokine production GO:0002369
Any process that contributes to cytokine production by a T cell.
|
1 | Q811D0 (/IMP) |
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
1 | Q811D0 (/ISO) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q62696 (/IEP) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | P31016 (/IMP) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q62108 (/ISO) |
Pole plasm protein localization GO:0007318
Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.
|
1 | P31007 (/IMP) |
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
1 | P31007 (/TAS) |
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | P31007 (/IMP) |
Mating behavior GO:0007617
The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
|
1 | P31007 (/IMP) |
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
|
1 | Q62108 (/NAS) |
Male courtship behavior GO:0008049
The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.
|
1 | P31007 (/IMP) |
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q811D0 (/IGI) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q811D0 (/IMP) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
1 | Q811D0 (/ISO) |
Regulation of Notch signaling pathway GO:0008593
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
|
1 | P31007 (/IMP) |
Synaptic vesicle maturation GO:0016188
Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.
|
1 | Q62108 (/IDA) |
Synaptic vesicle maturation GO:0016188
Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.
|
1 | Q62108 (/IGI) |
Morphogenesis of follicular epithelium GO:0016333
The process in which the anatomical structures of a follicular epithelium are generated and organized.
|
1 | P31007 (/IMP) |
Establishment or maintenance of polarity of follicular epithelium GO:0016334
Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet.
|
1 | P31007 (/IGI) |
Morphogenesis of larval imaginal disc epithelium GO:0016335
The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized.
|
1 | P31007 (/TAS) |
Establishment or maintenance of polarity of larval imaginal disc epithelium GO:0016336
Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium.
|
1 | P31007 (/IMP) |
Establishment or maintenance of polarity of larval imaginal disc epithelium GO:0016336
Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium.
|
1 | P31007 (/TAS) |
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
|
1 | Q91XM9 (/IMP) |
Septate junction assembly GO:0019991
The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space.
|
1 | P31007 (/TAS) |
Peristalsis GO:0030432
A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.
|
1 | Q811D0 (/IMP) |
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
|
1 | P31007 (/IMP) |
Regulation of border follicle cell delamination GO:0030710
Any process that regulates the frequency, rate or extent of border cell delamination.
|
1 | P31007 (/TAS) |
Anterior/posterior axis specification, follicular epithelium GO:0030714
Polarization of the follicle cells of an insect ovary along the anterior/posterior axis.
|
1 | P31007 (/IMP) |
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
|
1 | Q811D0 (/IMP) |
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
1 | Q811D0 (/ISO) |
Astral microtubule organization GO:0030953
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.
|
1 | Q811D0 (/ISO) |
Membrane raft organization GO:0031579
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.
|
1 | Q811D0 (/IMP) |
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
|
1 | Q811D0 (/IMP) |
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
|
1 | Q811D0 (/IMP) |
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q62696 (/IMP) |
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q811D0 (/ISO) |
Cellular protein-containing complex localization GO:0034629
A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.
|
1 | Q811D0 (/ISO) |
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
|
1 | Q62108 (/IMP) |
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
|
1 | P31016 (/ISS) |
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
1 | P31016 (/IMP) |
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
1 | Q62108 (/ISO) |
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
1 | Q62108 (/ISS) |
Locomotory exploration behavior GO:0035641
The specific movement from place to place of an organism in response to a novel environment.
|
1 | Q62108 (/IMP) |
Locomotory exploration behavior GO:0035641
The specific movement from place to place of an organism in response to a novel environment.
|
1 | P31016 (/ISS) |
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
1 | Q811D0 (/TAS) |
Regulation of epidermal growth factor receptor signaling pathway GO:0042058
Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | P31007 (/IMP) |
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
|
1 | Q811D0 (/IMP) |
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | P31007 (/TAS) |
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
1 | Q811D0 (/IMP) |
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
|
1 | Q62108 (/NAS) |
Gravitaxis GO:0042332
The directed movement of a motile cell or organism in response to gravity.
|
1 | P31007 (/IMP) |
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
1 | Q811D0 (/IGI) |
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
1 | Q811D0 (/ISO) |
Amyloid precursor protein metabolic process GO:0042982
The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
|
1 | Q811D0 (/IGI) |
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
|
1 | Q63622 (/IMP) |
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
|
1 | Q91XM9 (/ISO) |
Positive regulation of potassium ion transport GO:0043268
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q62696 (/IMP) |
Positive regulation of potassium ion transport GO:0043268
Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q811D0 (/ISO) |
Cortical microtubule organization GO:0043622
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
|
1 | Q811D0 (/ISO) |
Neuronal ion channel clustering GO:0045161
The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.
|
1 | Q63622 (/IMP) |
Neuronal ion channel clustering GO:0045161
The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.
|
1 | Q91XM9 (/ISO) |
Neuronal ion channel clustering GO:0045161
The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.
|
1 | P31016 (/TAS) |
Asymmetric protein localization involved in cell fate determination GO:0045167
Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
|
1 | P31007 (/IMP) |
Asymmetric protein localization involved in cell fate determination GO:0045167
Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
|
1 | P31007 (/TAS) |
Basal protein localization GO:0045175
Any process in which a protein is transported to, or maintained in, basal regions of the cell.
|
1 | P31007 (/IMP) |
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
|
1 | Q62108 (/ISO) |
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
|
1 | P70175 (/IMP) |
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
|
1 | P31007 (/TAS) |
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
|
1 | P31007 (/IMP) |
Negative regulation of imaginal disc growth GO:0045571
Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth.
|
1 | P31007 (/IMP) |
Positive regulation of synaptic growth at neuromuscular junction GO:0045887
Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
1 | P31007 (/IMP) |
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
|
1 | Q811D0 (/ISO) |
Regulation of receptor signaling pathway via JAK-STAT GO:0046425
Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.
|
1 | P31007 (/IMP) |
Positive phototaxis GO:0046956
The directed movement of a cell or organism towards a source of light.
|
1 | P31007 (/IMP) |
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
|
1 | P31007 (/IMP) |
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | Q62108 (/NAS) |
Regulation of long-term neuronal synaptic plasticity GO:0048169
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
|
1 | Q62108 (/IGI) |
Reproductive structure development GO:0048608
The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
|
1 | Q811D0 (/IMP) |
Positive regulation of developmental growth GO:0048639
Any process that activates, maintains or increases the rate of developmental growth.
|
1 | Q811D0 (/TAS) |
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
|
1 | Q811D0 (/IMP) |
Tissue morphogenesis GO:0048729
The process in which the anatomical structures of a tissue are generated and organized.
|
1 | Q811D0 (/IMP) |
Smooth muscle tissue development GO:0048745
The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.
|
1 | Q811D0 (/IMP) |
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
|
1 | Q811D0 (/IMP) |
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
|
1 | P31016 (/IDA) |
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
|
1 | Q62108 (/ISO) |
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
|
1 | Q62108 (/IMP) |
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
|
1 | P31016 (/ISS) |
Synaptic growth at neuromuscular junction GO:0051124
The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.
|
1 | P31007 (/IMP) |
Establishment of spindle orientation GO:0051294
Any process that set the alignment of spindle relative to other cellular structures.
|
1 | P31007 (/IMP) |
Establishment of centrosome localization GO:0051660
The directed movement of the centrosome to a specific location.
|
1 | Q811D0 (/ISO) |
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q811D0 (/IMP) |
Hard palate development GO:0060022
The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes.
|
1 | Q811D0 (/IMP) |
Cell fate commitment involved in pattern specification GO:0060581
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.
|
1 | P31007 (/IMP) |
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q62108 (/IDA) |
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | P31016 (/IMP) |
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q62108 (/ISO) |
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
1 | Q62108 (/ISO) |
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q811D0 (/ISO) |
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
|
1 | Q811D0 (/ISO) |
Vocalization behavior GO:0071625
The behavior in which an organism produces sounds by a mechanism involving its respiratory system.
|
1 | Q62108 (/IMP) |
Vocalization behavior GO:0071625
The behavior in which an organism produces sounds by a mechanism involving its respiratory system.
|
1 | P31016 (/ISS) |
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
1 | Q811D0 (/ISO) |
Dendritic spine organization GO:0097061
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
|
1 | P31016 (/IMP) |
Dendritic spine organization GO:0097061
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
|
1 | Q62108 (/ISO) |
AMPA glutamate receptor clustering GO:0097113
The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.
|
1 | P31016 (/IMP) |
AMPA glutamate receptor clustering GO:0097113
The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.
|
1 | Q62108 (/ISO) |
Receptor localization to synapse GO:0097120
Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
1 | P31016 (/IMP) |
Receptor localization to synapse GO:0097120
Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
1 | Q62108 (/ISO) |
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
|
1 | Q811D0 (/ISO) |
Regulation of ventricular cardiac muscle cell action potential GO:0098911
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
|
1 | Q811D0 (/IMP) |
Postsynaptic neurotransmitter receptor diffusion trapping GO:0098970
The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.
|
1 | P31016 (/IMP) |
Postsynaptic neurotransmitter receptor diffusion trapping GO:0098970
The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.
|
1 | Q62108 (/ISO) |
Regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072
Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
|
1 | P70175 (/IDA) |
Regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072
Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
|
1 | P70175 (/IMP) |
Anterograde axonal protein transport GO:0099641
The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
1 | Q91XM9 (/IGI) |
Anterograde axonal protein transport GO:0099641
The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
|
1 | Q15700 (/ISS) |
Retrograde axonal protein transport GO:0099642
The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
|
1 | Q91XM9 (/IGI) |
Retrograde axonal protein transport GO:0099642
The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
|
1 | Q15700 (/ISS) |
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
|
1 | Q811D0 (/ISO) |
Positive regulation of neuron projection arborization GO:0150012
Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
|
1 | P31016 (/IGI) |
Positive regulation of neuron projection arborization GO:0150012
Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
|
1 | Q62108 (/ISO) |
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
1 | Q811D0 (/ISO) |
Regulation of potassium ion import GO:1903286
Any process that modulates the frequency, rate or extent of potassium ion import.
|
1 | Q811D0 (/IMP) |
Negative regulation of p38MAPK cascade GO:1903753
Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.
|
1 | Q811D0 (/ISO) |
Regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1903760
Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.
|
1 | Q811D0 (/IMP) |
Regulation of potassium ion export across plasma membrane GO:1903764
Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane.
|
1 | Q811D0 (/IMP) |
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
|
1 | P31016 (/IDA) |
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
|
1 | P31016 (/IMP) |
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
|
1 | Q62108 (/ISO) |
Positive regulation of excitatory postsynaptic potential GO:2000463
Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
|
1 | P31016 (/IDA) |
Positive regulation of excitatory postsynaptic potential GO:2000463
Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
|
1 | P31016 (/IMP) |
Positive regulation of excitatory postsynaptic potential GO:2000463
Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
|
1 | Q62108 (/ISO) |
Regulation of grooming behavior GO:2000821
Any process that modulates the frequency, rate or extent of grooming behavior.
|
1 | Q62108 (/IMP) |
Regulation of grooming behavior GO:2000821
Any process that modulates the frequency, rate or extent of grooming behavior.
|
1 | P31016 (/ISS) |
There are 138 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
34 |
P70175 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(24 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
31 |
P31016 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(21 more) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
20 |
P31007 (/IDA)
P31016 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
(10 more) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
17 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(7 more) |
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
|
17 |
P31007 (/IDA)
P31016 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
(7 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
AMPA glutamate receptor complex GO:0032281
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Dendrite cytoplasm GO:0032839
All of the contents of a dendrite, excluding the surrounding plasma membrane.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Juxtaparanode region of axon GO:0044224
A region of an axon near a node of Ranvier that is between the paranode and internode regions.
|
15 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Neuron projection terminus GO:0044306
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Neuron spine GO:0044309
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
|
15 |
P31016 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(5 more) |
Endocytic vesicle membrane GO:0030666
The lipid bilayer surrounding an endocytic vesicle.
|
14 |
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
P78352 (/TAS)
(4 more) |
Cortical cytoskeleton GO:0030863
The portion of the cytoskeleton that lies just beneath the plasma membrane.
|
14 |
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
P78352 (/IDA)
(4 more) |
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
|
14 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(4 more) |
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
14 |
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
P78352 (/ISS)
(4 more) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
13 |
Q92796 (/HDA)
Q92796 (/HDA)
Q92796 (/HDA)
Q92796 (/HDA)
Q92796 (/HDA)
Q92796 (/HDA)
Q92796 (/HDA)
Q92796 (/HDA)
Q92796 (/HDA)
Q92796 (/HDA)
(3 more) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
8 | P31016 (/IDA) P70175 (/IDA) Q62108 (/IDA) Q62696 (/IDA) Q62936 (/IDA) Q63622 (/IDA) Q811D0 (/IDA) Q91XM9 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
7 | P31016 (/IMP) P70175 (/IMP) Q62108 (/IMP) Q62696 (/IMP) Q62936 (/IMP) Q811D0 (/IMP) Q91XM9 (/IMP) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | A0A2L2P595 (/IDA) P70175 (/IDA) Q12959 (/IDA) Q12959 (/IDA) Q62108 (/IDA) Q63622 (/IDA) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
6 | P31016 (/IDA) Q62108 (/IDA) Q62696 (/IDA) Q62936 (/IDA) Q811D0 (/IDA) Q91XM9 (/IDA) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
6 | Q3UP61 (/ISS) Q59FC4 (/ISS) Q5PYH5 (/ISS) Q5PYH6 (/ISS) Q62696 (/ISS) Q811D0 (/ISS) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
5 | Q12959 (/IDA) Q12959 (/IDA) Q62108 (/IDA) Q811D0 (/IDA) Q91XM9 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P70175 (/IDA) Q62108 (/IDA) Q62696 (/IDA) Q811D0 (/IDA) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
4 | P31016 (/IDA) P70175 (/IDA) Q12959 (/IDA) Q12959 (/IDA) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
4 | Q12959 (/IDA) Q12959 (/IDA) Q62696 (/IDA) Q811D0 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
4 | P31016 (/IDA) Q62108 (/IDA) Q62696 (/IDA) Q63622 (/IDA) |
Juxtaparanode region of axon GO:0044224
A region of an axon near a node of Ranvier that is between the paranode and internode regions.
|
4 | P31016 (/IDA) Q62108 (/IDA) Q63622 (/IDA) Q91XM9 (/IDA) |
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
4 | Q12959 (/IDA) Q12959 (/IDA) Q62108 (/IDA) Q811D0 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
4 | P70175 (/ISO) Q62108 (/ISO) Q811D0 (/ISO) Q91XM9 (/ISO) |
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
3 | Q12959 (/IDA) Q12959 (/IDA) Q811D0 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | A0A2L2P595 (/IDA) Q12959 (/IDA) Q12959 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | Q12959 (/IDA) Q12959 (/IDA) Q62108 (/IDA) |
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
|
3 | P70175 (/IDA) Q12959 (/IDA) Q12959 (/IDA) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
3 | P70175 (/ISO) Q62108 (/ISO) Q811D0 (/ISO) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
3 | Q62696 (/TAS) Q62936 (/TAS) Q63622 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | P31016 (/IDA) Q62108 (/IDA) Q63622 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
3 | Q62108 (/ISO) Q811D0 (/ISO) Q91XM9 (/ISO) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
3 | P31007 (/IDA) Q12959 (/IDA) Q12959 (/IDA) |
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
2 | Q12959 (/TAS) Q12959 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q811D0 (/ISO) Q91XM9 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
2 | Q62108 (/ISO) Q811D0 (/ISO) |
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
|
2 | Q12959 (/TAS) Q12959 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | Q62108 (/ISO) Q91XM9 (/ISO) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
2 | P31007 (/TAS) Q811D0 (/TAS) |
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
2 | P31007 (/IDA) Q811D0 (/IDA) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
2 | P31007 (/IDA) Q811D0 (/IDA) |
AMPA glutamate receptor complex GO:0032281
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.
|
2 | P70175 (/IDA) Q62108 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | Q62936 (/IDA) Q63622 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | P70175 (/ISO) Q91XM9 (/ISO) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
2 | P31016 (/IDA) Q62108 (/IDA) |
Juxtaparanode region of axon GO:0044224
A region of an axon near a node of Ranvier that is between the paranode and internode regions.
|
2 | Q62108 (/ISO) Q91XM9 (/ISO) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
2 | P31016 (/IMP) Q62108 (/IMP) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
2 | P70175 (/ISO) Q62108 (/ISO) |
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
|
2 | P31016 (/IDA) Q62108 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | Q12959 (/HDA) Q12959 (/HDA) |
MPP7-DLG1-LIN7 complex GO:0097025
A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.
|
2 | Q12959 (/IDA) Q12959 (/IDA) |
Anchored component of postsynaptic density membrane GO:0099031
The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
2 | P31016 (/IDA) Q63622 (/IDA) |
Anchored component of postsynaptic density membrane GO:0099031
The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
|
2 | Q62108 (/ISO) Q91XM9 (/ISO) |
Postsynaptic density, intracellular component GO:0099092
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
2 | Q62696 (/IDA) Q62936 (/IDA) |
Postsynaptic density, intracellular component GO:0099092
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
2 | P70175 (/ISO) Q811D0 (/ISO) |
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
|
1 | Q811D0 (/ISO) |
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
1 | Q811D0 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q811D0 (/ISO) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | Q811D0 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q811D0 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q62696 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q811D0 (/ISO) |
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
|
1 | Q811D0 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P31007 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P31007 (/IMP) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q811D0 (/ISO) |
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
|
1 | Q62696 (/IDA) |
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
|
1 | Q811D0 (/ISO) |
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
|
1 | Q811D0 (/TAS) |
Septate junction GO:0005918
A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods.
|
1 | P31007 (/IDA) |
Septate junction GO:0005918
A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods.
|
1 | P31007 (/NAS) |
Septate junction GO:0005918
A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods.
|
1 | P31007 (/TAS) |
Smooth septate junction GO:0005920
A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions.
|
1 | P31007 (/IDA) |
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
|
1 | Q811D0 (/ISO) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | P31007 (/IDA) |
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
|
1 | Q62108 (/IDA) |
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q811D0 (/ISO) |
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | Q62696 (/IDA) |
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | Q811D0 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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1 | Q15700 (/ISS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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1 | P31007 (/TAS) |
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
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1 | Q811D0 (/ISO) |
Apicolateral plasma membrane GO:0016327
The apical end of the lateral plasma membrane of epithelial cells.
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1 | P31007 (/IDA) |
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
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1 | P31007 (/HDA) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
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1 | Q811D0 (/ISO) |
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
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1 | Q62696 (/IDA) |
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
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1 | Q811D0 (/ISO) |
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
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1 | Q62936 (/IDA) |
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
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1 | P70175 (/ISO) |
Cortical cytoskeleton GO:0030863
The portion of the cytoskeleton that lies just beneath the plasma membrane.
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1 | Q62108 (/ISO) |
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
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1 | Q62108 (/IDA) |
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
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1 | Q811D0 (/IDA) |
Dendrite cytoplasm GO:0032839
All of the contents of a dendrite, excluding the surrounding plasma membrane.
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1 | P31016 (/IDA) |
Dendrite cytoplasm GO:0032839
All of the contents of a dendrite, excluding the surrounding plasma membrane.
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1 | Q62108 (/ISO) |
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
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1 | Q811D0 (/IDA) |
Paranode region of axon GO:0033270
An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.
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1 | Q62696 (/IDA) |
Paranode region of axon GO:0033270
An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.
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1 | Q811D0 (/ISO) |
Myelin sheath abaxonal region GO:0035748
The region of the myelin sheath furthest from the axon.
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1 | Q811D0 (/IDA) |
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
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1 | Q62696 (/IDA) |
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
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1 | Q811D0 (/ISO) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
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1 | Q62696 (/IDA) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
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1 | Q811D0 (/ISO) |
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
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1 | P31007 (/IDA) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
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1 | Q62108 (/ISO) |
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
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1 | Q62936 (/IDA) |
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
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1 | P70175 (/ISO) |
Lateral loop GO:0043219
Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.
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1 | Q811D0 (/IDA) |
Cerebellar mossy fiber GO:0044300
An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \mossy\ appearance in Golgi stained preparations.
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1 | Q62108 (/IDA) |
Neuron projection terminus GO:0044306
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
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1 | Q62108 (/IDA) |
Neuron spine GO:0044309
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
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1 | Q62108 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
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1 | Q811D0 (/IDA) |
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
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1 | P31007 (/IDA) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
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1 | P31007 (/TAS) |
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
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1 | Q62108 (/ISO) |
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
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1 | Q62696 (/TAS) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
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1 | Q811D0 (/ISO) |
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
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1 | Q62108 (/ISO) |
Type I terminal bouton GO:0061174
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
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1 | P31007 (/IDA) |
Type Ib terminal bouton GO:0061176
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons.
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1 | P31007 (/IDA) |
Tricellular tight junction GO:0061689
An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.
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1 | P31007 (/IDA) |
Subsynaptic reticulum GO:0071212
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
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1 | P31007 (/IDA) |
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
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1 | Q62108 (/IDA) |
MPP7-DLG1-LIN7 complex GO:0097025
A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.
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1 | Q811D0 (/ISO) |
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
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1 | Q62108 (/IDA) |
Postsynaptic density membrane GO:0098839
The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
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1 | Q62108 (/IDA) |