The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 101: Guanylate cyclase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
|
15 |
P16066 (/IDA)
P16066 (/IDA)
P18293 (/IDA)
P18293 (/IDA)
P18910 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
(5 more) |
|
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
|
12 |
P16066 (/IDA)
P16066 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
(2 more) |
|
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
|
11 |
P18293 (/IMP)
P18293 (/IMP)
P20594 (/IMP)
P20594 (/IMP)
P20594 (/IMP)
P20594 (/IMP)
P20594 (/IMP)
P20594 (/IMP)
P20594 (/IMP)
P20594 (/IMP)
(1 more) |
|
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
|
11 |
P16066 (/IPI)
P16066 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
(1 more) |
|
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
11 |
P16066 (/IPI)
P16066 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
P20594 (/IPI)
(1 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
10 | P18910 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) |
|
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
|
9 | P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) |
|
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
|
4 | P18293 (/ISS) P18293 (/ISS) P46197 (/ISS) P55202 (/ISS) |
|
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
|
3 | P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO) |
|
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
|
3 | P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO) |
Showing 1 to 10 of 19 entries
There are 38 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
|
11 |
P16066 (/IDA)
P16066 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
(1 more) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
11 |
P16066 (/IDA)
P16066 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
(1 more) |
|
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
|
11 |
P16066 (/TAS)
P16066 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
(1 more) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
9 | P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) |
|
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
|
9 | P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) |
|
Cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
|
9 | P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
4 | P16067 (/ISS) P46197 (/ISS) P55202 (/ISS) Q6VVW5 (/ISS) |
|
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
|
3 | P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO) |
|
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
|
3 | P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO) |
Showing 1 to 10 of 38 entries
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
12 |
P16066 (/TAS)
P16066 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
P20594 (/TAS)
(2 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
11 |
P16067 (/IDA)
P18910 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
P20594 (/IDA)
(1 more) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
9 | P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P16067 (/ISS) P46197 (/ISS) P55202 (/ISS) Q6VVW5 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P46197 (/ISS) P55202 (/ISS) Q6VVW5 (/ISS) |
|
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P16066 (/IDA) P16066 (/IDA) |
|
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P18293 (/ISO) P18293 (/ISO) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q6VVW5 (/ISO) |
Showing 1 to 9 of 9 entries
