The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
TPP-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: NAD-dependent protein deacylase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 38 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
NAD-dependent protein deacetylase activity GO:0034979
Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
36 P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA)
(26 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
31 P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI) P75960 (/IPI)
(21 more)
Protein-succinyllysine desuccinylase activity GO:0036055
Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
30 P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA)
(20 more)
NAD-dependent protein deacetylase activity GO:0034979
Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
27 P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP)
(17 more)
Protein-malonyllysine demalonylase activity GO:0036054
Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide.
15 E1BRE2 (/ISS) E1BRE2 (/ISS) E2RDZ6 (/ISS) F7D4X9 (/ISS) F7DKV7 (/ISS) F7EZ75 (/ISS) F7EZ75 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS) Q5HZN8 (/ISS)
(5 more)
Protein-succinyllysine desuccinylase activity GO:0036055
Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.
15 E1BRE2 (/ISS) E1BRE2 (/ISS) E2RDZ6 (/ISS) F7D4X9 (/ISS) F7DKV7 (/ISS) F7EZ75 (/ISS) F7EZ75 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS) Q5HZN8 (/ISS)
(5 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
11 E1BRE2 (/ISS) E1BRE2 (/ISS) F7DKV7 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS) Q5HZN8 (/ISS) Q5R6G3 (/ISS) Q5R6G3 (/ISS) Q68F47 (/ISS) Q68FX9 (/ISS)
(1 more)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
11 E1BRE2 (/ISS) E1BRE2 (/ISS) F7DKV7 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS) Q5HZN8 (/ISS) Q5R6G3 (/ISS) Q5R6G3 (/ISS) Q68F47 (/ISS) Q68FX9 (/ISS)
(1 more)
NAD+ nucleosidase activity GO:0003953
Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose.
8 P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA)
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
3 Q1JQC6 (/ISS) Q8IRR5 (/ISS) Q8R216 (/ISS)
Showing 1 to 10 of 38 entries

There are 73 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Peptidyl-lysine desuccinylation GO:0036049
The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein.
29 P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA)
(19 more)
Peptidyl-lysine deacetylation GO:0034983
The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.
28 P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA) P75960 (/IDA)
(18 more)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
27 P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP)
(17 more)
Peptidyl-lysine deacetylation GO:0034983
The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.
27 P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP)
(17 more)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
27 P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP) P75960 (/IMP)
(17 more)
Protein desuccinylation GO:0036048
The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein.
15 E1BRE2 (/ISS) E1BRE2 (/ISS) E2RDZ6 (/ISS) F7D4X9 (/ISS) F7DKV7 (/ISS) F7EZ75 (/ISS) F7EZ75 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS) Q5HZN8 (/ISS)
(5 more)
Regulation of ketone biosynthetic process GO:0010566
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells.
14 E1BRE2 (/ISS) E1BRE2 (/ISS) E2RDZ6 (/ISS) F7D4X9 (/ISS) F7DKV7 (/ISS) F7EZ75 (/ISS) F7EZ75 (/ISS) Q3ZBQ0 (/ISS) Q5R6G3 (/ISS) Q5R6G3 (/ISS)
(4 more)
Peptidyl-lysine demalonylation GO:0036047
The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein.
11 E1BRE2 (/ISS) E1BRE2 (/ISS) F7DKV7 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS) Q5HZN8 (/ISS) Q5R6G3 (/ISS) Q5R6G3 (/ISS) Q68F47 (/ISS) Q68FX9 (/ISS)
(1 more)
Peptidyl-lysine desuccinylation GO:0036049
The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein.
11 E1BRE2 (/ISS) E1BRE2 (/ISS) F7DKV7 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS) Q5HZN8 (/ISS) Q5R6G3 (/ISS) Q5R6G3 (/ISS) Q68F47 (/ISS) Q68FX9 (/ISS)
(1 more)
Protein deacetylation GO:0006476
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
10 P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) P9WGG3 (/IDA) Q9NXA8 (/IDA) Q9NXA8 (/IDA)
Showing 1 to 10 of 73 entries

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
19 E1BRE2 (/ISS) E1BRE2 (/ISS) E2RDZ6 (/ISS) F7D4X9 (/ISS) F7DKV7 (/ISS) F7EZ75 (/ISS) F7EZ75 (/ISS) Q1JQC6 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS)
(9 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 E1BRE2 (/ISS) E1BRE2 (/ISS) E2RDZ6 (/ISS) F7D4X9 (/ISS) F7DKV7 (/ISS) F7EZ75 (/ISS) F7EZ75 (/ISS) Q3ZBQ0 (/ISS) Q5HZN8 (/ISS) Q5HZN8 (/ISS)
(5 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
14 A0A024R012 (/IDA) A0A024R012 (/IDA) B2RZ30 (/IDA) G3V641 (/IDA) Q20480 (/IDA) Q20481 (/IDA) Q584D5 (/IDA) Q584D5 (/IDA) Q8IRR5 (/IDA) Q8K2C6 (/IDA)
(4 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
8 P9WGG3 (/HDA) P9WGG3 (/HDA) P9WGG3 (/HDA) P9WGG3 (/HDA) P9WGG3 (/HDA) P9WGG3 (/HDA) P9WGG3 (/HDA) P9WGG3 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
7 Q1JQC6 (/ISS) Q3ZBQ0 (/ISS) Q5R6G3 (/ISS) Q5R6G3 (/ISS) Q68FX9 (/ISS) Q8K2C6 (/ISS) Q8R216 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 Q4Q2Y6 (/ISO) Q584D5 (/ISO) Q584D5 (/ISO) Q8K2C6 (/ISO) Q8R216 (/ISO)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
5 Q3ZBQ0 (/ISS) Q5R6G3 (/ISS) Q5R6G3 (/ISS) Q68FX9 (/ISS) Q8K2C6 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
5 Q1JQC6 (/IDA) Q8R216 (/IDA) Q9NXA8 (/IDA) Q9NXA8 (/IDA) Q9Y6E7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q8K2C6 (/TAS) Q9NXA8 (/TAS) Q9NXA8 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 Q9NXA8 (/TAS) Q9NXA8 (/TAS) Q9Y6E7 (/TAS)
Showing 1 to 10 of 18 entries
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