The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
TPP-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Pyruvate decarboxylase isozyme

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Branched-chain-2-oxoacid decarboxylase. [EC: 4.1.1.72]
(3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO(2).
  • Acts on a number of 2-oxo acids, with a high affinity toward branched-chain substrates.
  • The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for biosynthesis of branched-chain fatty acids.
57 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VQ53
(47 more...)
Indolepyruvate decarboxylase. [EC: 4.1.1.74]
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).
  • More specific than EC 4.1.1.1.
57 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VQ53
(47 more...)
Phenylpyruvate decarboxylase. [EC: 4.1.1.43]
Phenylpyruvate = phenylacetaldehyde + CO(2).
  • Also acts on (indol-3-yl)pyruvate.
57 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VKT7 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VLD5 A0A0L8VQ53
(47 more...)
Pyruvate decarboxylase. [EC: 4.1.1.1]
A 2-oxo acid = an aldehyde + CO(2).
  • Also catalyzes acyloin formation.
9 A0A0W0CKR3 A0A0W0CKR3 C4YGJ3 C4YGJ3 P83779 P83779 Q09737 Q6FJA3 Q6FJA3
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