The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: GDP-fucose protein O-fucosyltransferase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fucosyltransferase activity GO:0008417
Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
15 Q00P48 (/ISS) Q00P49 (/ISS) Q18014 (/ISS) Q6EV66 (/ISS) Q6EV69 (/ISS) Q6EV69 (/ISS) Q6EV69 (/ISS) Q6EV70 (/ISS) Q7YRE7 (/ISS) Q7YRE7 (/ISS)
(5 more)
Peptide-O-fucosyltransferase activity GO:0046922
Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.
7 P83337 (/IDA) Q18014 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA) Q9V6X7 (/IDA) Q9V6X7 (/IDA)
Peptide-O-fucosyltransferase activity GO:0046922
Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.
6 P83337 (/TAS) Q9H488 (/TAS) Q9H488 (/TAS) Q9H488 (/TAS) Q9V6X7 (/TAS) Q9V6X7 (/TAS)
Fucosyltransferase activity GO:0008417
Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
3 Q9H488 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA)
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
2 Q9V6X7 (/IDA) Q9V6X7 (/IDA)
Fucosyltransferase activity GO:0008417
Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
1 Q91ZW2 (/ISO)
Transferase activity GO:0016740
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
1 P83337 (/IDA)
Transferase activity, transferring glycosyl groups GO:0016757
Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
1 P83337 (/IDA)
Peptide-O-fucosyltransferase activity GO:0046922
Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.
1 Q91ZW2 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein O-linked glycosylation GO:0006493
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
13 Q00P49 (/ISS) Q18014 (/ISS) Q6EV66 (/ISS) Q6EV69 (/ISS) Q6EV69 (/ISS) Q6EV69 (/ISS) Q6EV70 (/ISS) Q7YRE7 (/ISS) Q7YRE7 (/ISS) Q7YRZ3 (/ISS)
(3 more)
Regulation of Notch signaling pathway GO:0008593
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
6 P83337 (/ISS) Q6EV69 (/ISS) Q6EV69 (/ISS) Q6EV69 (/ISS) Q6EV70 (/ISS) Q91ZW2 (/ISS)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 Q9H488 (/NAS) Q9H488 (/NAS) Q9H488 (/NAS) Q9V6X7 (/NAS) Q9V6X7 (/NAS)
O-glycan processing GO:0016266
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure.
5 Q9H488 (/TAS) Q9H488 (/TAS) Q9H488 (/TAS) Q9V6X7 (/TAS) Q9V6X7 (/TAS)
Protein O-linked fucosylation GO:0036066
The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.
4 Q18014 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 Q9H488 (/NAS) Q9H488 (/NAS) Q9H488 (/NAS)
Protein O-linked glycosylation GO:0006493
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
3 Q9H488 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA)
Regulation of Notch signaling pathway GO:0008593
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
3 Q9H488 (/IMP) Q9H488 (/IMP) Q9H488 (/IMP)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
2 Q9V6X7 (/IMP) Q9V6X7 (/IMP)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
2 Q9V6X7 (/IMP) Q9V6X7 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q91ZW2 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q91ZW2 (/IMP)
Fucose metabolic process GO:0006004
The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose.
1 Q91ZW2 (/TAS)
Protein glycosylation GO:0006486
A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
1 P83337 (/IDA)
Protein O-linked glycosylation GO:0006493
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
1 Q91ZW2 (/ISO)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q91ZW2 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q91ZW2 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q91ZW2 (/IMP)
Regulation of Notch signaling pathway GO:0008593
Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
1 Q91ZW2 (/ISO)
Protein O-linked fucosylation GO:0036066
The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.
1 Q91ZW2 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
6 Q6EV70 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA) Q9V6X7 (/IDA) Q9V6X7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 Q6EV69 (/ISS) Q6EV69 (/ISS) Q6EV69 (/ISS) Q6EV70 (/ISS) Q91ZW2 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q9H488 (/HDA) Q9H488 (/HDA) Q9H488 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q9H488 (/IDA) Q9H488 (/IDA) Q9H488 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q91ZW2 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q18014 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 P83337 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q91ZW2 (/ISO)
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