CATH Superfamily 3.40.50.11260
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 3: Heat shock protein 90
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | P08113 (/IPI) P08113 (/IPI) P08113 (/IPI) P14625 (/IPI) P14625 (/IPI) P14625 (/IPI) P14625 (/IPI) Q9VAY2 (/IPI) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q95M18 (/ISS) |
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
|
1 | Q95M18 (/ISS) |
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
|
1 | Q9VAY2 (/ISS) |
There are 36 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
|
18 |
O18750 (/ISS)
P08113 (/ISS)
P08113 (/ISS)
P08113 (/ISS)
P08712 (/ISS)
P41148 (/ISS)
P41148 (/ISS)
Q29092 (/ISS)
Q4R520 (/ISS)
Q4R520 (/ISS)
(8 more) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
6 | A0A286YAP4 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) Q7T3L3 (/IDA) |
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | P14625 (/NAS) P14625 (/NAS) P14625 (/NAS) P14625 (/NAS) |
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
|
4 | P14625 (/IMP) P14625 (/IMP) P14625 (/IMP) P14625 (/IMP) |
Retrograde protein transport, ER to cytosol GO:0030970
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
|
4 | P14625 (/IMP) P14625 (/IMP) P14625 (/IMP) P14625 (/IMP) |
Actin rod assembly GO:0031247
The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Protein folding in endoplasmic reticulum GO:0034975
A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
ATF6-mediated unfolded protein response GO:0036500
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | P14625 (/IMP) P14625 (/IMP) P14625 (/IMP) P14625 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Regulation of phosphoprotein phosphatase activity GO:0043666
Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Sequestering of calcium ion GO:0051208
The process of binding or confining calcium ions such that they are separated from other components of a biological system.
|
4 | P14625 (/NAS) P14625 (/NAS) P14625 (/NAS) P14625 (/NAS) |
Cellular response to ATP GO:0071318
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Retrograde protein transport, ER to cytosol GO:0030970
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Actin rod assembly GO:0031247
The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Regulation of phosphoprotein phosphatase activity GO:0043666
Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Cellular response to ATP GO:0071318
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Otolith tethering GO:0035889
The attachment of a developing otolith to the kinocilia of tether cells in the inner ear.
|
2 | A0A286YAP4 (/IMP) Q7T3L3 (/IMP) |
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
2 | A0A286YAP4 (/IMP) Q7T3L3 (/IMP) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | Q95M18 (/ISS) |
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
|
1 | Q9VAY2 (/ISS) |
Intracellular sequestering of iron ion GO:0006880
The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.
|
1 | P08110 (/TAS) |
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
|
1 | Q9VAY2 (/IMP) |
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
1 | Q9VAY2 (/ISS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q95M18 (/ISS) |
Endodermal digestive tract morphogenesis GO:0061031
The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.
|
1 | Q9VAY2 (/IMP) |
Cellular response to manganese ion GO:0071287
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
|
1 | Q66HD0 (/IEP) |
There are 32 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
11 |
P08113 (/IDA)
P08113 (/IDA)
P08113 (/IDA)
P14625 (/IDA)
P14625 (/IDA)
P14625 (/IDA)
P14625 (/IDA)
V9HWP2 (/IDA)
V9HWP2 (/IDA)
V9HWP2 (/IDA)
(1 more) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
7 | P08113 (/TAS) P08113 (/TAS) P08113 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
5 | P08110 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
4 | P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
4 | P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) |
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
4 | P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) P14625 (/IDA) |
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
4 | P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
4 | P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) P14625 (/HDA) |
Endocytic vesicle lumen GO:0071682
The volume enclosed by the membrane of an endocytic vesicle.
|
4 | P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) P14625 (/TAS) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Smooth endoplasmic reticulum GO:0005790
The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P08113 (/IDA) P08113 (/IDA) P08113 (/IDA) |
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Endoplasmic reticulum chaperone complex GO:0034663
A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.
|
3 | P08113 (/IDA) P08113 (/IDA) P08113 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
3 | P08113 (/ISO) P08113 (/ISO) P08113 (/ISO) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | P08110 (/ISS) Q95M18 (/ISS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9VAY2 (/IDA) |
Smooth endoplasmic reticulum GO:0005790
The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
|
1 | Q66HD0 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q95M18 (/ISS) |
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
|
1 | Q9VAY2 (/HDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q95M18 (/ISS) |