The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
CoaB-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Phosphopantothenate--cysteine ligase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphopantothenate--cysteine ligase activity GO:0004632
Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.
11 P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) Q8GXR5 (/IDA)
(1 more)
Phosphopantothenate--cysteine ligase activity GO:0004632
Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.
9 P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P40506 (/IPI) P40506 (/IPI) P40506 (/IPI) P40506 (/IPI) P40506 (/IPI) P40506 (/IPI) P40506 (/IPI) P40506 (/IPI) P40506 (/IPI)
Phosphopantothenate--cysteine ligase activity GO:0004632
Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.
1 Q9USK7 (/IMP)
Phosphopantothenate--cysteine ligase activity GO:0004632
Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.
1 Q8VDG5 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9HAB8 (/IMP)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Coenzyme A biosynthetic process GO:0015937
The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
10 P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) P40506 (/ISS) Q54S85 (/ISS)
Coenzyme A biosynthetic process GO:0015937
The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
9 P40506 (/IGI) P40506 (/IGI) P40506 (/IGI) P40506 (/IGI) P40506 (/IGI) P40506 (/IGI) P40506 (/IGI) P40506 (/IGI) P40506 (/IGI)
Coenzyme A biosynthetic process GO:0015937
The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
2 Q8GXR5 (/IDA) Q9HAB8 (/IDA)
Coenzyme A biosynthetic process GO:0015937
The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
2 Q9HAB8 (/IMP) Q9USK7 (/IMP)
Heart process GO:0003015
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q9HAB8 (/IMP)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
1 Q9HAB8 (/IMP)
Coenzyme biosynthetic process GO:0009108
The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 Q9HAB8 (/TAS)
Coenzyme A biosynthetic process GO:0015937
The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
1 Q8VDG5 (/ISO)
Acetyl-CoA biosynthetic process from pantothenate GO:1990181
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA.
1 Q9USK7 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) Q9USK7 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA) P40506 (/HDA)
CoA-synthesizing protein complex GO:1990143
A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway.
9 P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA) P40506 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9USK7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9USK7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9USK7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9HAB8 (/TAS)
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