The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Uracil-DNA glycosylase-like domain
".
FunFam 2: G/T mismatch-specific thymine DNA glycosylase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 41 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
4 | A0A096MIY3 (/IDA) A1L1J2 (/IDA) F7EYN3 (/IDA) Q99NG8 (/IDA) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
4 | A0A096MIY3 (/IDA) A1L1J2 (/IDA) F7EYN3 (/IDA) Q99NG8 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | Q13569 (/IDA) Q9V4D8 (/IDA) Q9XYZ3 (/IDA) |
|
Pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263
Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.
|
3 | Q13569 (/IDA) Q9V4D8 (/IDA) Q9XYZ3 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P56581 (/IPI) Q13569 (/IPI) |
|
DNA N-glycosylase activity GO:0019104
Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
|
2 | P56581 (/IDA) Q13569 (/IDA) |
|
DNA N-glycosylase activity GO:0019104
Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
|
2 | Q13569 (/TAS) Q9PUA4 (/TAS) |
|
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
|
2 | P56581 (/IPI) Q13569 (/IPI) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | Q13569 (/IDA) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | P56581 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P56581 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q13569 (/ISS) |
|
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
|
1 | Q13569 (/TAS) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | P56581 (/ISO) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | P56581 (/ISS) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
1 | P56581 (/IGI) |
|
Uracil DNA N-glycosylase activity GO:0004844
Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
|
1 | Q13569 (/IDA) |
|
Uracil DNA N-glycosylase activity GO:0004844
Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
|
1 | P56581 (/ISO) |
|
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
1 | P56581 (/IPI) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q13569 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | P56581 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P56581 (/ISO) |
|
Pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263
Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.
|
1 | Q13569 (/IMP) |
|
Pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263
Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.
|
1 | P56581 (/ISO) |
|
DNA N-glycosylase activity GO:0019104
Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
|
1 | P56581 (/ISO) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | P56581 (/ISO) |
|
Mismatched DNA binding GO:0030983
Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.
|
1 | Q13569 (/IDA) |
|
Mismatched DNA binding GO:0030983
Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.
|
1 | P56581 (/ISO) |
|
Mismatched DNA binding GO:0030983
Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.
|
1 | P56581 (/ISS) |
|
Sodium ion binding GO:0031402
Interacting selectively and non-covalently with sodium ions (Na+).
|
1 | Q13569 (/IDA) |
|
Sodium ion binding GO:0031402
Interacting selectively and non-covalently with sodium ions (Na+).
|
1 | P56581 (/ISO) |
|
Chloride ion binding GO:0031404
Interacting selectively and non-covalently with chloride ions (Cl-).
|
1 | Q13569 (/IDA) |
|
Chloride ion binding GO:0031404
Interacting selectively and non-covalently with chloride ions (Cl-).
|
1 | P56581 (/ISO) |
|
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
|
1 | P56581 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q13569 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P56581 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P56581 (/ISS) |
|
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
1 | Q13569 (/IDA) |
|
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
1 | P56581 (/ISO) |
|
G/U mismatch-specific uracil-DNA glycosylase activity GO:0043739
Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site.
|
1 | Q13569 (/IMP) |
|
G/U mismatch-specific uracil-DNA glycosylase activity GO:0043739
Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site.
|
1 | P56581 (/ISO) |
There are 26 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | A0A096MIY3 (/IMP) A1L1J2 (/IMP) F7EYN3 (/IMP) P56581 (/IMP) Q99NG8 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
4 | A0A096MIY3 (/IDA) A1L1J2 (/IDA) F7EYN3 (/IDA) Q99NG8 (/IDA) |
|
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
|
3 | Q13569 (/IDA) Q9V4D8 (/IDA) Q9XYZ3 (/IDA) |
|
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
|
2 | P56581 (/IDA) Q13569 (/IDA) |
|
Depyrimidination GO:0045008
The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar.
|
2 | Q13569 (/TAS) Q9PUA4 (/TAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P56581 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P56581 (/ISO) |
|
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
|
1 | P56581 (/ISO) |
|
Base-excision repair GO:0006284
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
|
1 | Q13569 (/TAS) |
|
Base-excision repair, AP site formation GO:0006285
The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.
|
1 | Q13569 (/IDA) |
|
Base-excision repair, AP site formation GO:0006285
The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.
|
1 | Q13569 (/IMP) |
|
Base-excision repair, AP site formation GO:0006285
The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.
|
1 | P56581 (/ISO) |
|
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
|
1 | P56581 (/ISO) |
|
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
|
1 | P56581 (/ISS) |
|
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
1 | P56581 (/IDA) |
|
Oxidative DNA demethylation GO:0035511
Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
1 | Q13569 (/TAS) |
|
Negative regulation of chromatin binding GO:0035562
Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | P56581 (/IDA) |
|
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
|
1 | P56581 (/IMP) |
|
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
|
1 | Q13569 (/ISS) |
|
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
|
1 | P56581 (/IMP) |
|
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
|
1 | Q13569 (/ISS) |
|
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
|
1 | P56581 (/IDA) |
|
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
|
1 | P56581 (/IMP) |
|
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
|
1 | Q13569 (/ISS) |
|
Regulation of DNA N-glycosylase activity GO:1902544
Any process that modulates the frequency, rate or extent of DNA N-glycosylase activity.
|
1 | Q13569 (/IMP) |
|
Regulation of DNA N-glycosylase activity GO:1902544
Any process that modulates the frequency, rate or extent of DNA N-glycosylase activity.
|
1 | P56581 (/ISO) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | A0A096MIY3 (/IDA) A1L1J2 (/IDA) F7EYN3 (/IDA) P56581 (/IDA) Q13569 (/IDA) Q99NG8 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | B4E127 (/IDA) F5H0I7 (/IDA) G8JL98 (/IDA) Q13569 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | B4E127 (/IDA) F5H0I7 (/IDA) G8JL98 (/IDA) Q13569 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q13569 (/TAS) Q9PUA4 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P56581 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P56581 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P56581 (/ISO) |
