The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Collagenase (Catalytic Domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Disintegrin and metalloproteinase domain-containin...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
5 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) Q9VAC5 (/IDA)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
5 P78536 (/TAS) P78536 (/TAS) P78536 (/TAS) P78536 (/TAS) Q9Z0F8 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P78536 (/IPI) P78536 (/IPI) P78536 (/IPI) P78536 (/IPI) Q9Z0F8 (/IPI)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
5 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) Q9Z0F8 (/IDA)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
5 P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) Q9Z0F8 (/IMP)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
4 P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) P78536 (/IMP)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
4 P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) P78536 (/IMP)
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
4 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA)
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
4 P78536 (/IPI) P78536 (/IPI) P78536 (/IPI) P78536 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
4 P78536 (/IPI) P78536 (/IPI) P78536 (/IPI) P78536 (/IPI)
Showing 1 to 10 of 23 entries

There are 102 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
6 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) Q9VAC5 (/IDA) Q9Z0F8 (/IDA)
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
6 P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) Q9Z0F8 (/IMP) Q9Z1K9 (/IMP)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
6 G3V711 (/ISS) P78536 (/ISS) P78536 (/ISS) P78536 (/ISS) P78536 (/ISS) Q9Z1K9 (/ISS)
Receptor transactivation GO:0035624
The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer.
5 P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) Q9Z1K9 (/IMP)
PMA-inducible membrane protein ectodomain proteolysis GO:0051088
The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist.
5 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) Q9Z0F8 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
4 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
4 P78536 (/IMP) P78536 (/IMP) P78536 (/IMP) P78536 (/IMP)
Neutrophil mediated immunity GO:0002446
Any process involved in the carrying out of an immune response by a neutrophil.
4 P78536 (/IC) P78536 (/IC) P78536 (/IC) P78536 (/IC)
Germinal center formation GO:0002467
The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.
4 P78536 (/ISS) P78536 (/ISS) P78536 (/ISS) P78536 (/ISS)
Positive regulation of leukocyte chemotaxis GO:0002690
Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
4 P78536 (/IC) P78536 (/IC) P78536 (/IC) P78536 (/IC)
Showing 1 to 10 of 102 entries

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 B2RNB2 (/IDA) B2RNB2 (/IDA) B2RNB2 (/IDA) B2RNB2 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) Q9Z0F8 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P78536 (/TAS) P78536 (/TAS) P78536 (/TAS) P78536 (/TAS) Q9Z0F8 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
5 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) Q9Z1K9 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
4 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P78536 (/HDA) P78536 (/HDA) P78536 (/HDA) P78536 (/HDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
4 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 P78536 (/IDA) P78536 (/IDA) P78536 (/IDA) P78536 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9Z0F8 (/TAS)
Showing 1 to 10 of 26 entries
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